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D-Serine

Name: D-Serine
Brand: TargetMol
SKU: T8394
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8394Cas No. 312-84-5

Alias (R)-Serine

D-Serine ((R)-Serine), an endogenous amino acid, is a potent co-agonist at the NMDA glutamate receptor.

D-Serine

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Purity: 99.93%

Catalog No. T8394Alias (R)-SerineCas No. 312-84-5

D-Serine ((R)-Serine), an endogenous amino acid, is a potent co-agonist at the NMDA glutamate receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$31	In Stock	In Stock
2 g	$35	-	In Stock
5 g	$40	-	In Stock
10 g	$60	-	In Stock
1 mL x 10 mM (in H2O)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.93%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

D-Serine AI Summary

D-Serine demonstrates a broad spectrum of bioactivities. It exhibits NMDA receptor modulatory effects with EC50 values recorded at 320.0 nM (NR1/NR2A), 260.0 nM (NR1/NR2B), 210.0 nM (NR1/NR2C), and 170.0 nM (NR1/NR2D). It also shows inhibition of [3H]glycine and [3H]TCP binding with IC50 values of 300.0 nM and EC50 of 200.0 nM, respectively, and competes with [3H]MK 801 at EC50 of 160.0 nM. In addition, it has shown antiviral properties against SARS-CoV-2 with varied inhibition percentages and IC50 values greater than 20000 nM in VERO-6 cells. Furthermore, D-Serine displays antimicrobial potential against Staphylococcus aureus, inhibiting growth and biofilm formation by 85.0% and 83.0% respectively at 100 µM. It also acts as an inhibitor of Bloom's syndrome helicase (BLM), human tyrosyl-DNA phosphodiesterase 1 (TDP1), and various serine transporters and uptake mechanisms. Additionally, it shows moderate inhibition of the human HDAC6 enzyme and mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1). Pharmacokinetic studies highlight its high bioavailability and prolonged half-life, rapidly reaching peak concentrations in the bloodstream post-oral administration. These multifaceted bioactivities of D-Serine make it a compelling candidate for further drug development..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	D-Serine ((R)-Serine), an endogenous amino acid, is a potent co-agonist at the NMDA glutamate receptor.
Synonyms	(R)-Serine

Chemical Properties

Molecular Weight	105.09
Formula	C₃H₇NO₃
Cas No.	312-84-5
Smiles	[C@H](C(O)=O)(CO)N
Relative Density.	1.3895 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: Insoluble

H2O: 100 mg/mL (951.57 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	9.5157 mL	47.5783 mL	95.1565 mL	475.7827 mL
5 mM	1.9031 mL	9.5157 mL	19.0313 mL	95.1565 mL
10 mM	0.9516 mL	4.7578 mL	9.5157 mL	47.5783 mL
20 mM	0.4758 mL	2.3789 mL	4.7578 mL	23.7891 mL
50 mM	0.1903 mL	0.9516 mL	1.9031 mL	9.5157 mL
100 mM	0.0952 mL	0.4758 mL	0.9516 mL	4.7578 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc