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Traxoprodil

Catalog No. TQ0233 CAS 134234-12-1

Synonyms: CP101606

Traxoprodil is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).

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Traxoprodil, CAS 134234-12-1

Pack Size	Availability	Price/USD
5 mg	In stock	53.00
10 mg	In stock	69.00
25 mg	In stock	134.00
50 mg	In stock	231.00
100 mg	In stock	393.00

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Purity 99.86%

HNMR HPLC COA

Datasheet SDS

Biological Description

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Storage & Solubility Information

Description

Traxoprodil is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).

Animal Research

The effect of traxoprodil and SPD on PTZ-induced seizures is investigated by injecting the Adult (90-100 days-old) male Wistar rats (250-300 g) with traxoprodil (0.2, 2 or 20 nM/site), SPD (0.02, 0.2 or 2 nM/site), or with vehicle (0.9% NaCl, 1 μL) 15 min before the administration of PTZ (35 or 70 mg/kg, i.p.) [3]. The Forced swim test is done on male Albino Swiss mice (25-30 g). Traxoprodil (5, 10, 20, 40 mg/kg), imipramine and saline are administered i.p. 60 min before the test. The antidepressant activity is measured [2].

Synonyms	CP101606
Purity	99.86%
Molecular Weight	327.42
Formula	C20H25NO3
CAS No.	134234-12-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: 62.5 mg/mL (190.89 mM), Need ultrasonic

H2O: < 0.1 mg/mL (insoluble)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Chenard BL, et al. (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses. J Med Chem. 1995 Aug 4;38(16):3138-45. 2. Poleszak E, et al. Traxoprodil, a selective antagonist of the NR2B subunit of the NMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice. Metab Brain Dis. 2016 Aug;31(4):803-14. 3. Naspolini AP, et al. Traxoprodil decreases pentylenetetrazol-induced seizures. Epilepsy Res. 2012 Jun;100(1-2):12-9.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Clinical Compound Library Drug Repurposing Compound Library

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