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Catalog No. TQ0233   CAS 134234-12-1
Synonyms: 曲索罗地, CP101606

Traxoprodil is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).

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Traxoprodil, CAS 134234-12-1
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Traxoprodil is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).
Targets&IC50 NMDA Receptor:10 nM
In vivo Traxoprodil is potent at blocking haloperidol-induced catalepsy and with an ED50 less than 1 mg/kg. Traxoprodil is effective at 1 mg/kg to block NMDA (i.p.) stimulated c-fos induction in mice [1]. Traxoprodil at a dose of 20 and 40 mg/kg exhibits antidepressant activity in the forced swim test and it is not related to changes in animals’ locomotor activity [2]. Traxoprodil (20 nM i.c.v.) increases the latency to generalized tonic-clonic seizures induced by PTZ (70 mg/kg; i.p.). Traxoprodil (60 mg/kg, p.o.) increases the latency to clonic and generalized seizures and decreases the total time spent in seizures [3].
Animal Research The effect of traxoprodil and SPD on PTZ-induced seizures is investigated by injecting the Adult (90-100 days-old) male Wistar rats (250-300 g) with traxoprodil (0.2, 2 or 20 nM/site), SPD (0.02, 0.2 or 2 nM/site), or with vehicle (0.9% NaCl, 1 μL) 15 min before the administration of PTZ (35 or 70 mg/kg, i.p.) [3]. The Forced swim test is done on male Albino Swiss mice (25-30 g). Traxoprodil (5, 10, 20, 40 mg/kg), imipramine and saline are administered i.p. 60 min before the test. The antidepressant activity is measured [2].
Synonyms 曲索罗地, CP101606
Molecular Weight 327.42
Formula C20H25NO3
CAS No. 134234-12-1


Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 62.5 mg/mL (190.89 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Chenard BL, et al. (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses. J Med Chem. 1995 Aug 4;38(16):3138-45. 2. Poleszak E, et al. Traxoprodil, a selective antagonist of the NR2B subunit of the NMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice. Metab Brain Dis. 2016 Aug;31(4):803-14. 3. Naspolini AP, et al. Traxoprodil decreases pentylenetetrazol-induced seizures. Epilepsy Res. 2012 Jun;100(1-2):12-9.

Related compound libraries

This product is contained In the following compound libraries:
Neurotransmitter Receptor Compound Library Drug Repurposing Compound Library Neuronal Signaling Compound Library Bioactive Compound Library Clinical Compound Library

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Traxoprodil 134234-12-1 离子通道 神经科学 iGluR NMDAR Ionotropic glutamate receptors inhibit CP101606 Inhibitor inhibitor