Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride) is a synthetic analogue of Joro spider toxin and is an antagonist of calcium permeable AMPA (CP-AMPA) receptors.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 54.00 | |
5 mg | In stock | $ 87.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 92.00 |
Description | Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride) is a synthetic analogue of Joro spider toxin and is an antagonist of calcium permeable AMPA (CP-AMPA) receptors. |
Targets&IC50 | AMPAR:0.33 μM |
In vitro | NASPM selectively suppressed the inwardly rectifying and Ca(2+)-permeable AMPA receptors expressed in type II neurons. It had no effect on AMPA receptors in type I neurons. The blocking effect of NASPM on the Ca(2+)-permeable AMPA receptors was use and voltage-dependent. When the effect of NASPM reached a steady state, current responses induced by ionophoretic applications of kainate, a non-desensitizing agonist of AMPA receptors, in type II neurons were suppressed by NASPM in a dose-dependent manner at -60 mV (IC50 0.33 microM, and Hill coefficient 0.94). The response to kainate recovered partially after washing out NASPM. NASPM did not affect the Ca(2+)-permeable AMPA receptors when the neuronal membrane was held at potentials more positive than +40 mV. Furthermore, the blockade by NASPM which was attained at negative potentials was transiently removed by shifting membrane potential to +60 mV for 5 s together with a single ionophoretic application of kainate. |
Synonyms | 1-Naphthylacetyl spermine trihydrochloride |
Molecular Weight | 479.91 |
Formula | C22H37Cl3N4O |
CAS No. | 1049731-36-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 50 mg/mL (104.19 mM), sonification is recommended.
DMSO: 6.4 mg/mL (13.34 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Naspm trihydrochloride 1049731-36-3 Membrane transporter/Ion channel Neuroscience iGluR inhibit Inhibitor 1-Naphthylacetyl spermine trihydrochloride 1-Naphthylacetyl spermine Trihydrochloride Naspm Trihydrochloride Naspm 1-Naphthylacetyl spermine Ionotropic glutamate receptors inhibitor