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Naspm trihydrochloride

Catalog No. T12187L   CAS 1049731-36-3
Synonyms: 1-Naphthylacetyl spermine trihydrochloride

Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride) is a synthetic analogue of Joro spider toxin and is an antagonist of calcium permeable AMPA (CP-AMPA) receptors.

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Naspm trihydrochloride Chemical Structure
Naspm trihydrochloride, CAS 1049731-36-3
Pack Size Availability Price/USD Quantity
2 mg In stock $ 54.00
5 mg In stock $ 87.00
1 mL * 10 mM (in DMSO) In stock $ 92.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride) is a synthetic analogue of Joro spider toxin and is an antagonist of calcium permeable AMPA (CP-AMPA) receptors.
Targets&IC50 AMPAR:0.33 μM
In vitro NASPM selectively suppressed the inwardly rectifying and Ca(2+)-permeable AMPA receptors expressed in type II neurons. It had no effect on AMPA receptors in type I neurons. The blocking effect of NASPM on the Ca(2+)-permeable AMPA receptors was use and voltage-dependent. When the effect of NASPM reached a steady state, current responses induced by ionophoretic applications of kainate, a non-desensitizing agonist of AMPA receptors, in type II neurons were suppressed by NASPM in a dose-dependent manner at -60 mV (IC50 0.33 microM, and Hill coefficient 0.94). The response to kainate recovered partially after washing out NASPM. NASPM did not affect the Ca(2+)-permeable AMPA receptors when the neuronal membrane was held at potentials more positive than +40 mV. Furthermore, the blockade by NASPM which was attained at negative potentials was transiently removed by shifting membrane potential to +60 mV for 5 s together with a single ionophoretic application of kainate.
Synonyms 1-Naphthylacetyl spermine trihydrochloride
Molecular Weight 479.91
Formula C22H37Cl3N4O
CAS No. 1049731-36-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 50 mg/mL (104.19 mM), sonification is recommended.

DMSO: 6.4 mg/mL (13.34 mM), sonification is recommended.

TargetMolReferences and Literature

1. Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29(1):27-36.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library Bioactive Compounds Library Max Anti-Cancer Compound Library Bioactive Compound Library Neurotransmitter Receptor Compound Library Neuronal Signaling Compound Library

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Keywords

Naspm trihydrochloride 1049731-36-3 Membrane transporter/Ion channel Neuroscience iGluR inhibit Inhibitor 1-Naphthylacetyl spermine trihydrochloride 1-Naphthylacetyl spermine Trihydrochloride Naspm Trihydrochloride Naspm 1-Naphthylacetyl spermine Ionotropic glutamate receptors inhibitor

 

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