Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Radiprodil (RGH-896) (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPNP).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
2 mg | In stock | $ 59.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 155.00 | |
25 mg | In stock | $ 253.00 | |
50 mg | In stock | $ 372.00 | |
100 mg | In stock | $ 559.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 97.00 |
Description | Radiprodil (RGH-896) (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPNP). |
Targets&IC50 | NR2B:69 nM |
In vitro | The inhibition potency of ligands toward the NR2B NMDA receptors was evaluated by measuring the Ca2t influx evocated by NMDA application (at 100 mM for 30 s) in NR1a/NR2B subunit transfected HEK cells. Radiprodil had potent inhibitory effects (69 nM) towards Ca2+ influx [1]. A low concentration (10?nM) of the GLUN2B receptor antagonist Radiprodil restored LTP in the presence of Aβ1-42, 3NTyr10-Aβ, Aβ1-40, but not AβpE3. Radiprodil (10?nM) reversed the synaptic toxicity of Aβ species but not that of AβpE3 [2]. |
In vivo | The in vivo analgesic efficiency for 1a in the mouse formalin test was 7.7 mg/kg p.o. (ED50) and a clinical trial is currently conducted with Radiprodil [1]. |
Synonyms | RGH-896 |
Molecular Weight | 397.4 |
Formula | C21H20FN3O4 |
CAS No. | 496054-87-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 220 mg/mL (553.6 mM)
You can also refer to dose conversion for different animals. More
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Radiprodil 496054-87-6 Membrane transporter/Ion channel Neuroscience NMDAR iGluR Ionotropic glutamate receptors RGH-896 RGH896 inhibit Inhibitor RGH 896 inhibitor