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DL-AP5

Catalog No. T22733 CAS 76326-31-3

NMDA antagonist

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

DL-AP5, CAS 76326-31-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 30.00
5 mg	In stock	$ 68.00
10 mg	In stock	$ 113.00
25 mg	In stock	$ 228.00
50 mg	In stock	$ 372.00
100 mg	In stock	$ 549.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

NMDA antagonist

In vivo

DL-AP5, a competitive NMDAR antagonist, on tramadol state-dependent memory.?A single-trial step-down passive avoidance task was used for the assessment of memory retrieval in adult male NMRI mice.?Post-training i.p. administration of an atypical μ-opioid receptor agonist, tramadol (2.5 and 5 mg/kg), dose-dependently induced impairment of memory retention.?Pre-test injection of tramadol (2.5 and 5 mg/kg) induced state-dependent retrieval of the memory acquired under post-training administration of tramadol (5 mg/kg) influence.?Pre-test intra-CA1 injection of NMDA (10-5 and 10-4 μg/mouse) 5 min before the administration of tramadol (5 mg/kg, i.p.) dose-dependently inhibited tramadol state-dependent memory.?Pre-test intra-CA1 injection of DL-AP5 (0.25 and 0.5 μg/mouse) reversed the memory impairment induced by post-training administration of tramadol (5 mg/kg).?Pre-test administration of DL-AP5 (0.25 and 0.5 μg/mouse) with an ineffective dose of tramadol (1.25 mg/kg) restored the retrieval and induced tramadol state-dependent memory.?It can be concluded that dorsal hippocampal NMDAR mechanisms play an important role in the modulation of tramadol state-dependent memory.

Molecular Weight	197.13
Formula	C5H12NO5P
CAS No.	76326-31-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

H2O: 10 mM

DMSO: Insoluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Jafari-Sabet M , Mofidi H , Attarian-Khosroshahi M S . NMDA receptors in the dorsal hippocampal area are involved in tramadol state-dependent memory of passive avoidance learning in mice[J]. Canadian Journal of Physiology and Pharmacology, 2017:cjpp-2017-0228.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Parkinson's Disease Compound Library NO PAINS Compound Library Neurotransmitter Receptor Compound Library Antidepressant Compound Library Neuronal Signaling Compound Library Target-Focused Phenotypic Screening Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

DL-AP5 76326-31-3 Neuroscience NMDAR 2-APV Retina Tonic pain Ganglion cells Ionotropic glutamate receptors Inhibitor inhibit DL-AP-5 Inhibition DL AP5 Antinociceptive activity iGluR DLAP5 inhibitor

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