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Catalog No. T22733   CAS 76326-31-3

NMDA antagonist

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
DL-AP5, CAS 76326-31-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 30.00
5 mg In stock $ 68.00
10 mg In stock $ 113.00
25 mg In stock $ 228.00
50 mg In stock $ 372.00
100 mg In stock $ 549.00
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description NMDA antagonist
In vivo DL-AP5, a competitive NMDAR antagonist, on tramadol state-dependent memory.?A single-trial step-down passive avoidance task was used for the assessment of memory retrieval in adult male NMRI mice.?Post-training i.p. administration of an atypical μ-opioid receptor agonist, tramadol (2.5 and 5 mg/kg), dose-dependently induced impairment of memory retention.?Pre-test injection of tramadol (2.5 and 5 mg/kg) induced state-dependent retrieval of the memory acquired under post-training administration of tramadol (5 mg/kg) influence.?Pre-test intra-CA1 injection of NMDA (10-5 and 10-4 μg/mouse) 5 min before the administration of tramadol (5 mg/kg, i.p.) dose-dependently inhibited tramadol state-dependent memory.?Pre-test intra-CA1 injection of DL-AP5 (0.25 and 0.5 μg/mouse) reversed the memory impairment induced by post-training administration of tramadol (5 mg/kg).?Pre-test administration of DL-AP5 (0.25 and 0.5 μg/mouse) with an ineffective dose of tramadol (1.25 mg/kg) restored the retrieval and induced tramadol state-dependent memory.?It can be concluded that dorsal hippocampal NMDAR mechanisms play an important role in the modulation of tramadol state-dependent memory.
Molecular Weight 197.13
Formula C5H12NO5P
CAS No. 76326-31-3


Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

H2O: 10 mM

DMSO: Insoluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Jafari-Sabet M , Mofidi H , Attarian-Khosroshahi M S . NMDA receptors in the dorsal hippocampal area are involved in tramadol state-dependent memory of passive avoidance learning in mice[J]. Canadian Journal of Physiology and Pharmacology, 2017:cjpp-2017-0228.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library Bioactive Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Parkinson's Disease Compound Library NO PAINS Compound Library Neurotransmitter Receptor Compound Library Antidepressant Compound Library Neuronal Signaling Compound Library Target-Focused Phenotypic Screening Library Bioactive Compounds Library Max

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DL-AP5 76326-31-3 Neuroscience NMDAR 2-APV Retina Tonic pain Ganglion cells Ionotropic glutamate receptors Inhibitor inhibit DL-AP-5 Inhibition DL AP5 Antinociceptive activity iGluR DLAP5 inhibitor