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MDL-29951

Catalog No. T1897   CAS 130798-51-5

MDL-29951 is a novel glycine antagonist of NMDA receptor activation.

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MDL-29951 Chemical Structure
MDL-29951, CAS 130798-51-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 72.00
2 mg In stock $ 97.00
5 mg In stock $ 177.00
10 mg In stock $ 317.00
25 mg In stock $ 573.00
50 mg In stock $ 823.00
100 mg In stock $ 1,130.00
1 mL * 10 mM (in DMSO) In stock $ 183.00
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Purity: 99.49%
Purity: 99.22%
Purity: 99.07%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description MDL-29951 is a novel glycine antagonist of NMDA receptor activation.
Targets&IC50 NMDA:0.14 μM
In vitro MDL 100,748 and MDL 29,951 are approximately 2000-fold selective for the glycine binding site relative to the glutamate recognition sites[1]. MDL-29951 is found to inhibit the human F16Bpase under these conditions (IC50=2.5 μM). MDL-29951 inhibits the human liver (IC50=2.5 μM), porcine kidney (IC50=1.0 μM), and rabbit liver (IC50=0.21 μM) isoforms of the enzyme, but is significantly less potent against the rat liver isoform (IC50=11 μM)[2]. The MDL29951-activated receptor exhibits other activities associated with GPCR-mediated signaling, including G protein-dependent activation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and recruitment of β-arrestin. As with recombinant cell systems, MDL29951 promotes Ca2+ signaling responses and inhibition of cyclic adenosine monophosphate (cAMP) accumulation in rat oligodendrocyte precursor cells during the period of peak GPR17 abundance. Effects of MDL29951 are markedly reduced in cells with low GPR17 abundance and are blocked by pranlukast[3].
Kinase Assay [3H]JCPP (30.7 Ci/mmol) binding assays are conducted in minivials, incubated for 15 mm at 25°C in 1 mL of 50 mM Tris-HC1 (pH 7.4) containing 10 nM [3H]JCPP, 200 g of membrane protein and unlabeled ligands as indicated. Nonspecific binding is defined using 1 mM L-glutamate. Bound ligand is separated by centrifugation. Specific binding accounted for approximately 80% of total binding.
Molecular Weight 302.11
Formula C12H9Cl2NO4
CAS No. 130798-51-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (165.5 mM)

TargetMolReferences and Literature

1. Baron BM, et al. Potent indole- and quinoline-containing N-methyl-D-aspartate antagonists acting at the strychnine-insensitive glycine binding site. J Pharmacol Exp Ther. 1992 Sep;262(3):947-56. 2. Wright SW, et al. 3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2055-8. 3. Harden TK. Enigmatic GPCR finds a stimulating drug. Sci Signal. 2013 Oct 22;6(298):pe34.

Related compound libraries

This product is contained In the following compound libraries:
Membrane Protein-targeted Compound Library Inhibitor Library Anti-Neurodegenerative Disease Compound Library Neuronal Signaling Compound Library Bioactive Compound Library Target-Focused Phenotypic Screening Library Anti-Alzheimer's Disease Compound Library NO PAINS Compound Library Neurotransmitter Receptor Compound Library Anti-Parkinson's Disease Compound Library

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Keywords

MDL-29951 130798-51-5 Membrane transporter/Ion channel Neuroscience iGluR NMDAR Ionotropic glutamate receptors Inhibitor MDL 29951 MDL29951 inhibit inhibitor

 

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