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Orphenadrine hydrochloride

Catalog No. T1308 CAS 341-69-5

Synonyms: Mephenamin, Mebedrol

Orphenadrine hydrochloride is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.

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Orphenadrine hydrochloride, CAS 341-69-5

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Orphenadrine hydrochloride is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
Targets&IC50	N-methyl-D-aspartate (NMDA) receptor:6.0 ±0.7 μM (Ki)

Synonyms	Mephenamin, Mebedrol
Molecular Weight	305.85
Formula	C18H23NO·HCl
CAS No.	341-69-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 45 mg/mL (147.13 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kornhuber J, et al. J Neural Transm Gen Sect. 1995;102(3):237-46.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Orphenadrine hydrochloride 341-69-5 GPCR/G Protein Immunology/Inflammation Membrane transporter/Ion channel Neuroscience Histamine Receptor iGluR NMDAR Sodium Channel Norepinephrine Ionotropic glutamate receptors Mephenamin spasticity HSP27 parkinson's syndrome PBR Inhibitor inhibit CGC cells neuroprotective properties Mebedrol Orphenadrine inhibitor

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