Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. EC50 value: 2.7 μM for NR2C and 2.8 μM for NR2D.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 47.00 | |
5 mg | In stock | $ 77.00 | |
10 mg | In stock | $ 127.00 | |
25 mg | In stock | $ 247.00 | |
50 mg | In stock | $ 368.00 | |
100 mg | In stock | $ 543.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 85.00 |
Description | CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. EC50 value: 2.7 μM for NR2C and 2.8 μM for NR2D. |
Targets&IC50 | NR2C:2.7 μM(EC50), NR2D:2.8 μM(EC50) |
In vitro | CIQ reduces associated behaviours in schizophrenia models and potentially enhances dopamine release in Parkinson's disease models. NMDA receptor CIQ increases channel opening frequency of recombinant NR2Cor NR2D containing receptors by two-fold (EC50 = 2.7 and 2.8 μM, respectively). It has no effect on NR2A or NR2B subtypes. CIQ does not alter the EC50 values for glutamate or glycine on channel opening. CIQ increases channel opening efficiency and enhances NMDA receptor responses. |
Molecular Weight | 467.94 |
Formula | C26H26ClNO5 |
CAS No. | 486427-17-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (106.85 mM)
H2O: insoluble
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CIQ 486427-17-2 Neuroscience NMDAR Ionotropic glutamate receptors Inhibitor inhibit iGluR inhibitor