Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cycloleucine is an antagonist of NMDA receptor associated glycine receptor with a Ki of 600 μM. Cycloleucine is also a competitive inhibitor of S-adenosyl-methionine mediated methylation with anxiolytic and cytostatic effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 39.00 | |
50 mg | In stock | $ 55.00 | |
100 mg | In stock | $ 80.00 | |
200 mg | In stock | $ 118.00 | |
500 mg | In stock | $ 197.00 |
Description | Cycloleucine is an antagonist of NMDA receptor associated glycine receptor with a Ki of 600 μM. Cycloleucine is also a competitive inhibitor of S-adenosyl-methionine mediated methylation with anxiolytic and cytostatic effects. |
In vitro | Cytostatic (10 µg/mL) inhibits the viability of human KB and mouse L1210s leukemia cell lines. Cycloleucine (4-40 mM; 3 h) blocks internal methylation of viral RNA in B77 transformed chick embryo fibroblasts. Cycloleucine (40 mM; 24 h) blocks the formation of both m6A and the penultimate Gm in B77 38S RNA subunits by greater than 90%[2]. |
In vivo | Cycloleucine (0.5, 1.0, 2.0, 4 µg/µL; intracerebroventrically) increases time spent in open arms, open arm entries, and extreme arrivals in rats[3]. In Semliki Forest virus strain A7(74) infected and control mice, Cycloleucine reduces thymus and spleen weights[4]. |
Molecular Weight | 129.16 |
Formula | C6H11NO2 |
CAS No. | 52-52-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 45 mg/mL (348.41 mM), Sonication is recommended.
DMSO: < 1 mg/mL (insoluble or slightly soluble), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Cycloleucine 52-52-8 Neuroscience NMDAR Ionotropic glutamate receptors inhibit glycine NMDA cytostatic nucleic Inhibitor methylations anxiolytic transferase iGluR ATP inhibitor