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HBT1

Catalog No. T8779 CAS 489408-02-8

HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate dependent manner.

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HBT1, CAS 489408-02-8

Pack Size	Availability	Price/USD
5 mg	In stock	$ 41.00
10 mg	In stock	$ 66.00
25 mg	In stock	$ 132.00
50 mg	In stock	$ 197.00
100 mg	In stock	$ 332.00
1 mL * 10 mM (in DMSO)	In stock	$ 68.00

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Purity: 99.48%

Biological Description

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Description	HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate dependent manner.
In vitro	HBT1 bound to the ligand-binding domain (LBD) of AMPA-R in a glutamate-dependent manner.?The mode of HBT1 and LY451395 binding to a pocket in the LBD of AMPA-R differed: HBT1, formed hydrogen bonds with S518 in the LBD.?Lower agonistic profile of HBT1 may associate with its lower risks of bell-shaped responses in BDNF production in primary neurons.

Molecular Weight	386.39
Formula	C16H17F3N4O2S
CAS No.	489408-02-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.87 mg/mL (10 mM)

References and Literature

1. Kunugi A , Tajima Y , Kuno H , et al. HBT1, a novel AMPA receptor potentiator with lower agonistic effect, avoided bell-shaped response in in vitro BDNF production[J]. Journal of Pharmacology & Experimental Therapeutics, 2018:jpet.117.245050.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library NO PAINS Compound Library Neurotransmitter Receptor Compound Library Neuronal Signaling Compound Library Antidepressant Compound Library Anti-Alzheimer's Disease Compound Library Neuronal Differentiation Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Keywords

HBT1 489408-02-8 Neuroscience GluR HBT-1 Ionotropic glutamate receptors BDNF LBD inhibit glutamate HBT 1 AMPA primary neurons S518 iGluR AMPA-R Inhibitor inhibitor

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