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Search Results for " rsk "

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Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T60922	RSK-IN-1
	RSK-IN-1 (compound 7d) shows anti-tumor activity. RSK-IN-1 is an inhibitor of RSK that inhibits the phosphorylation of YB-1 [1].
T14779	BRD7389		SGK , FLT , Pim , CDK , S6 Kinase , DAPK
	BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.		SGK , FLT , Pim , CDK , S6 Kinase , DAPK
T22422	S6K-18		S6 Kinase
	S6K-18, a highly selective S6K1 inhibitor, inhibits S6K1 with IC50 of 52nM.		S6 Kinase
T5428	BIX 02565		LRRK2 , S6 Kinase
	BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).		LRRK2 , S6 Kinase
T2002	PF-4708671	PF4708671	S6 Kinase , Autophagy
	PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) .In cell-free assays, PF-4708671(PF4708671) is potent for S6K1(Ki50=20 nM, IC50=160 nM).		S6 Kinase , Autophagy
T6877	LJH685		Apoptosis , S6 Kinase
	LJH685 is an effective pan-RSK inhibitor for RSK1/2/3 (IC50: 6/5/4 nM).		Apoptosis , S6 Kinase
T4301	AD80		Raf , c-RET , Src , S6 Kinase
	AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.		Raf , c-RET , Src , S6 Kinase
T6304	AT7867		Akt , PKA , S6 Kinase
	AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the AGC kinase family.		Akt , PKA , S6 Kinase
T6171	BI-D1870		S6 Kinase , Autophagy
	BI-D1870 is a cell-permeable, ATP-competitive inhibitor of ribosomal S6 kinases (RSKs; IC50s: 31/24/18/15 nM for RSK1/2/3/4).		S6 Kinase , Autophagy
T6878	LJI308		S6 Kinase
	LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.		S6 Kinase
T6948	Pluripotin	SC1	ERK , Raf , S6 Kinase
	Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP.		ERK , Raf , S6 Kinase
T7790	Bisindolylmaleimide V		PKC , S6 Kinase
	Bisindolylmaleimide V, a bisindolylmaleimide derivative, is an inactive of a kinase inhibitor.		PKC , S6 Kinase
T6159	LY-2584702 free base		S6 Kinase , mTOR
	LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).		S6 Kinase , mTOR
T1746	LY-2584702 tosylate salt	LY2584702 tosylate	S6 Kinase
	LY-2584702 tosylate salt is a selective, ATP-competitive p70S6K inhibitor, used in trials studying the treatment of cancer.		S6 Kinase
T4488	GSK-25	GSK25	ROCK , S6 Kinase , mTOR
	GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).		ROCK , S6 Kinase , mTOR
T2482	AT13148		ROCK , SGK , Akt , PKA , S6 Kinase
	AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.		ROCK , SGK , Akt , PKA , S6 Kinase
T8978	DD1	3,3'-Diamino-4'-methoxyflavone,HUN85111	Proteasome
	DD1 (HUN85111) is a proteasome inhibitor that induces human myeloid tumor-selective apoptosis.		Proteasome
T19913	CKI-7	CKI 7 2HCl,CKI-7 dihydrochloride,CKI7 2HCl,CKI 7 dihydrochloride,CKI7 dihydrochloride,CKI-7 2HCl	ROCK , SGK , Casein Kinase , CDK , S6 Kinase
	CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1), and MSK1.		ROCK , SGK , Casein Kinase , CDK , S6 Kinase
T61766	RSK4-IN-1
	RSK4-IN-1 is a compound exhibiting potent inhibition of RSK4, demonstrated by an IC50 value of 9.5 nM.
T62718	RSK2-IN-3
	RSK2-IN-3 (Compound 26) is a covalent, reversible inhibitor of RPS6KA3 (RSK2) kinase.
T36720	Deacetylforskolin
	Deacetylforskolin is a diterpene and a derivative of forskolin that has been found inC. forskohliiand has diverse biological activities.1,2,3,4It activates rat adipocyte adenylyl cyclase (IC50= 20 μM) and inhibits glucos...
T22467	1,9-Dideoxyforskolin		Others
	The compound is an inactive analog of forskolin(an adenylyl cyclase activator).		Others
T60585	RSK2-IN-2
	RSK2-IN-2 (Compound 25) is a reversible covalent inhibitor of the RPS6KA3 ( RSK2 ) kinase which also inhibits MSK1, MSK2, and RSK3 [1].
TQ0310	FMK		S6 Kinase
	FMK is an irreversible inhibitor of RSK2 kinase.		S6 Kinase
T4327	Prexasertib dihydrochloride	LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368	Apoptosis , Chk , S6 Kinase
	Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively.		Apoptosis , Chk , S6 Kinase
T7005	Ulixertinib	BVD-523,VRT752271	ERK
	Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.		ERK
T68781	3Ac-SL0101
	3Ac-SL0101 is a potent RSK-specific inhibitor. It facilitates the development of RSK inhibitors as anti-cancer chemotherapeutic agents.
T28695	SB-747651A	SB 747651A
	SB-747651A is a potent, ATP-competitive inhibitor of mitogen- and stress-activated kinase 1 (MSK1, IC50 = 11 nM). It targets the N-terminal kinase domain. SB-747651A inhibits MSK1, MSK2, PKA, PKB, RSK and p70S6K activity...
T26103	RMM-46
	RMM-46 is a reversible and selective covalent inhibitor for MSK/RSK-family kinases.
T11310	FMK-MEA		Others
	FMK-MEA is a potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor.		Others
T81041	TAS0612		Akt
	TAS0612, a novel oral inhibitor of RSK, AKT, and S6K, exhibits broad-spectrum antitumor activity by impeding cell growth [1].		Akt
T15377	Ravoxertinib hydrochloride	GDC-0994 (hydrochloride)	ERK
	Ravoxertinib hydrochloride is an orally bioavailable and selective inhibitor for ERK kinase activity (IC50: 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively).		ERK

Cat No.	Product Name	Synonyms	Targets
T6S1302	Carnosol		Nrf2 , Endogenous Metabolite , S6 Kinase
	Carnosol is an Nrf2 activator, increasing Nrf2 levels and promoting heme oxygenase 1 (HMOX1) expression. It is a ribosomal S6 kinase (RSK2) inhibitor and can be used in gastric cancer-related research with an IC50 value ...		Nrf2 , Endogenous Metabolite , S6 Kinase
T3836	Eudesmin		MAPK , S6 Kinase
	Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.50 m...		MAPK , S6 Kinase
T2871	Quercitrin	Sophoretin,3-rhamnosyl quercetin,Quercetin 3-rhamnoside,Xanthaurine,Meletin	Reactive Oxygen Species , S6 Kinase , Autophagy
	Quercitrin (3-rhamnosyl quercetin) is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities. Quercitrin can be found in a number of food items such as garden tomato (var. ), German cam...		Reactive Oxygen Species , S6 Kinase , Autophagy
T0335	Sodium salicylate	Salicylic acid sodium salt,2-Hydroxybenzoic acid sodium salt	Apoptosis , NF-κB , COX , S6 Kinase , Autophagy
	Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.		Apoptosis , NF-κB , COX , S6 Kinase , Autophagy
TN1520	Isoforskolin	Coleonol B	IL Receptor , TNF
	Isoforskolin is derived from Coleus forskohlii and reduces the secretion of TNF-α, IL-1β, IL-6 and IL-8 in human mononuclear leukocytes. Isoforskolin can be used in studies about the treatment of Lyme arthritis.		IL Receptor , TNF
T2939	Forskolin	Coleonol,Colforsin	FXR , Adenylyl cyclase , AChR , Autophagy
	Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the...		FXR , Adenylyl cyclase , AChR , Autophagy
TN4073	Forskolin G		Others
	Forskolin is known to elevate intracellular cAMP levels.		Others
TN4074	Forskolin J		Others
	Forskolin J is a natural product for research related to life sciences. The catalog number is TN4074 and the CAS number is 81873-08-7.		Others
T16896	SL 0101-1	SL0101	S6 Kinase
	SL 0101-1 (SL0101) is a selective, efficient, reversible and ATP-competitive inhibitor of p90 ribosomal S6 kinase (RSK) that can permeate cell membranes, with an IC50 value of 89 nM for RSK.SL 0101-1 (SL0101) is also a p...		S6 Kinase

Cat No.	Product Name	Species	Expression System
TMPY-04392	RSK3 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	Ribosomal protein S6 kinase alpha-2, also known as 9 kDa ribosomal protein S6 kinase 2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, Ribosomal S6 kinase 3, RSK-3, RPS6KA2 and MAPKAPK1C, is a ...
TMPY-04357	RSK4 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	Ribosomal protein S6 kinase alpha-6, also known as Ribosomal S6 kinase 4, 9 kDa ribosomal protein S6 kinase 6,RSK-4, RSK4 and RPS6KA6, is a protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kina...
TMPY-04540	S6K1/RPS6KB1 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	PS6K, also known as RPS6KB1, is a serine/threonine-protein kinase. It belongs to the RSK (ribosomal s6 kinase) family. Members of this family function in signal transduction. PS6K is an isoform of p70 ribosomal S6 kinase...