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Catalog No. T6877   CAS 1627710-50-2

LJH685 is an effective pan-RSK inhibitor for RSK1/2/3 (IC50: 6/5/4 nM).

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LJH685 Chemical Structure
LJH685, CAS 1627710-50-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 33.00
2 mg In stock $ 45.00
5 mg In stock $ 81.00
10 mg In stock $ 147.00
25 mg In stock $ 296.00
50 mg In stock $ 471.00
100 mg In stock $ 688.00
1 mL * 10 mM (in DMSO) In stock $ 93.00
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Purity: 99.78%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description LJH685 is an effective pan-RSK inhibitor for RSK1/2/3 (IC50: 6/5/4 nM).
Targets&IC50 RSK3:4 nM, RSK2:5 nM, RSK1:6 nM
In vitro LJH685 modulates YB1 phosphorylation by potently and selectively inhibiting RSK in cells. In MAPK pathway–dependent cancer cell lines, LJH685 shows antiproliferative effects, and causes cell-cycle regulation and apoptosis induction. [1]
Kinase Assay Inhibition of RSK1, RSK2, and RSK3 activity: Enzymatic activity of RSK isoforms 1, 2, and 3 (PV4049, PV4051, and PV3846) is assessed using recombinant full-length RSK protein. RSK1 (1 nmol/L), RSK2 (0.1 nmol/L), or RSK3 (1 nmol/L) is allowed to phosphorylate 200 nmol/L peptide substrate (biotin-AGAGRSRHSSYPAGT-OH) in the presence of ATP at concentration equal to the Km for ATP for each enzyme (RSK1, 5 μmol/L; RSK2, 20 μmol/L; and RSK3, 10 μmol/L) and appropriate dilutions of RSK inhibitors.
Cell Research Cell growth under attached conditions is assessed by plating 1000 cells per well on 96-well tissue culture-treated plates in cell growth medium. Appropriate dilutions of compound are added medium above cells and cell growth is assessed after 72 hrs by addition of CellTiter Glo reagent according to manufacturer's directions.(Only for Reference)
Molecular Weight 381.42
Formula C22H21F2N3O
CAS No. 1627710-50-2


Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 71 mg/mL (186.1 mM)

Ethanol: 16 mg/mL (41.9 mM)

H2O: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Aronchik I, et al. Mol Cancer Res. 2014, 12(5), 803-812.

Related compound libraries

This product is contained In the following compound libraries:
PI3K-AKT-mTOR Compound Library Anti-Pancreatic Cancer Compound Library Oxidation-Reduction Compound Library Inhibitor Library Anti-Lung Cancer Compound Library Anti-Prostate Cancer Compound Library Antidepressant Compound Library Cancer Cell Differentiation Compound Library Glycometabolism Compound Library Glycolysis Compound Library

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LJH685 1627710-50-2 Apoptosis MAPK PI3K/Akt/mTOR signaling S6 Kinase S6K LJH-685 inhibit Ribosomal S6 Kinase (RSK) LJH 685 Inhibitor inhibitor