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Catalog No. T6877Cas No. 1627710-50-2
LJH685 is an effective pan-RSK inhibitor for RSK1/2/3 (IC50: 6/5/4 nM).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$33In Stock
2 mg$45In Stock
5 mg$81In Stock
10 mg$147In Stock
25 mg$296In Stock
50 mg$471In Stock
100 mg$688In Stock
1 mL x 10 mM (in DMSO)$93In Stock
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Product Introduction

LJH685 is an effective pan-RSK inhibitor for RSK1/2/3 (IC50: 6/5/4 nM).
In vitro
LJH685 modulates YB1 phosphorylation by potently and selectively inhibiting RSK in cells. In MAPK pathway–dependent cancer cell lines, LJH685 shows antiproliferative effects, and causes cell-cycle regulation and apoptosis induction. [1]
Kinase Assay
Inhibition of RSK1, RSK2, and RSK3 activity: Enzymatic activity of RSK isoforms 1, 2, and 3 (PV4049, PV4051, and PV3846) is assessed using recombinant full-length RSK protein. RSK1 (1 nmol/L), RSK2 (0.1 nmol/L), or RSK3 (1 nmol/L) is allowed to phosphorylate 200 nmol/L peptide substrate (biotin-AGAGRSRHSSYPAGT-OH) in the presence of ATP at concentration equal to the Km for ATP for each enzyme (RSK1, 5 μmol/L; RSK2, 20 μmol/L; and RSK3, 10 μmol/L) and appropriate dilutions of RSK inhibitors.
Cell Research
Cell growth under attached conditions is assessed by plating 1000 cells per well on 96-well tissue culture-treated plates in cell growth medium. Appropriate dilutions of compound are added medium above cells and cell growth is assessed after 72 hrs by addition of CellTiter Glo reagent according to manufacturer's directions.(Only for Reference)
Chemical Properties
Molecular Weight381.42
Cas No.1627710-50-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 71 mg/mL (186.1 mM)
Ethanol: 16 mg/mL (41.9 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
1 mM2.6218 mL13.1089 mL26.2178 mL131.0891 mL
5 mM0.5244 mL2.6218 mL5.2436 mL26.2178 mL
10 mM0.2622 mL1.3109 mL2.6218 mL13.1089 mL
20 mM0.1311 mL0.6554 mL1.3109 mL6.5545 mL
50 mM0.0524 mL0.2622 mL0.5244 mL2.6218 mL
100 mM0.0262 mL0.1311 mL0.2622 mL1.3109 mL


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