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CKI-7 (Alias: CKI-7 dihydrochloride, CKI7 dihydrochloride, CKI-7 2HCl, CKI7 2HCl, CKI 7 dihydrochloride||...)

Name: CKI-7
Brand: TargetMol
SKU: T19913
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T19913 Copy Product Info

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CKI-7 is a potent, ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. It also inhibits SGK, ribosomal S6 kinase-1 (S6K1), and MSK1.

CKI-7

Copy Product Info

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Catalog No. T19913

Alias CKI-7 dihydrochloride, CKI7 dihydrochloride, CKI-7 2HCl, CKI7 2HCl, CKI 7 dihydrochloride, CKI 7 2HCl

CKI-7 is a potent, ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. It also inhibits SGK, ribosomal S6 kinase-1 (S6K1), and MSK1.

Cas No. 1177141-67-1

Pack Size	Price	USA Stock	Global Stock
1 mg	$30	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$123	In Stock	In Stock
25 mg	$276	In Stock	In Stock
50 mg	$450	In Stock	In Stock
100 mg	$606	-	In Stock
1 mL x 10 mM (in DMSO)	$77	In Stock	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:>99.99%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	CKI-7 is a potent, ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. It also inhibits SGK, ribosomal S6 kinase-1 (S6K1), and MSK1.
Targets&IC50	CK1:6 μM(IC50), CK1:8.5 μM(Ki)
Synonyms	CKI-7 dihydrochloride, CKI7 dihydrochloride, CKI-7 2HCl, CKI7 2HCl, CKI 7 dihydrochloride, CKI 7 2HCl

Chemical Properties

Molecular Weight	358.67
Formula	C₁₁H₁₄Cl₃N₃O₂S
Cas No.	1177141-67-1
Smiles	Cl.Cl.NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (181.23 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7881 mL	13.9404 mL	27.8808 mL	139.4039 mL
5 mM	0.5576 mL	2.7881 mL	5.5762 mL	27.8808 mL
10 mM	0.2788 mL	1.3940 mL	2.7881 mL	13.9404 mL
20 mM	0.1394 mL	0.6970 mL	1.3940 mL	6.9702 mL
50 mM	0.0558 mL	0.2788 mL	0.5576 mL	2.7881 mL
100 mM	0.0279 mL	0.1394 mL	0.2788 mL	1.3940 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc