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CKI-7

Catalog No. T19913   CAS 1177141-67-1
Synonyms: CKI 7 2HCl, CKI-7 dihydrochloride, CKI7 2HCl, CKI 7 dihydrochloride, CKI7 dihydrochloride, CKI-7 2HCl

CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1), and MSK1.

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CKI-7 Chemical Structure
CKI-7, CAS 1177141-67-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 193.00
2 mg In stock $ 259.00
5 mg In stock $ 382.00
10 mg In stock $ 573.00
25 mg In stock $ 922.00
50 mg In stock $ 1,250.00
100 mg In stock $ 1,690.00
1 mL * 10 mM (in DMSO) In stock $ 418.00
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Purity: 100.00%
Purity: 100.00%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1), and MSK1.
Targets&IC50 CK1:6 μM(IC50), CK1:8.5 μM(Ki)
Synonyms CKI 7 2HCl, CKI-7 dihydrochloride, CKI7 2HCl, CKI 7 dihydrochloride, CKI7 dihydrochloride, CKI-7 2HCl
Molecular Weight 358.67
Formula C11H14Cl3N3O2S
CAS No. 1177141-67-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/ml (181.23 mM)

TargetMolReferences and Literature

1. Osakada F, et al. In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J Cell Sci. 2009 Sep 1;122(Pt 17):3169-79. 2. Rachidi N, Taly JF, Durieu E, Leclercq O, Aulner N, Prina E, Pescher P, Notredame C, Meijer L, Späth GF. Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection. Antimicrob Agents Chemother. 2014;58(3):1501-15. doi: 10.1128/AAC.02022-13. Epub 2013 Dec 23. PubMed PMID: 24366737; PubMed Central PMCID: PMC3957854. 3. Tian Y, Yue X, Luo D, Wazir R, Wang J, Wu T, Chen L, Liao B, Wang K. Increased proliferation of human bladder smooth muscle cells is mediated by physiological cyclic stretch via the PI3K SGK1 Kv1.3 pathway. Mol Med Rep. 2013 Jul;8(1):294-8. doi: 10.3892/mmr.2013.1473. Epub 2013 May 13. PubMed PMID: 23669863. 4. Boesger J, Wagner V, Weisheit W, Mittag M. Application of phosphoproteomics to find targets of casein kinase 1 in the flagellum of chlamydomonas. Int J Plant Genomics. 2012;2012:581460. doi: 10.1155/2012/581460. Epub 2012 Dec 18. PubMed PMID: 23316220; PubMed Central PMCID: PMC3536430.

Related compound libraries

This product is contained In the following compound libraries:
TGF-beta/Smad Compound Library Inhibitor Library MAPK Inhibitor Library Bioactive Compounds Library Max NO PAINS Compound Library Metabolism Compound Library Anti-Lung Cancer Compound Library Anti-Ovarian Cancer Compound Library Cytoskeletal Signaling Pathway Compound Library Stem Cell Differentiation Compound Library

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Keywords

CKI-7 1177141-67-1 Cell Cycle/Checkpoint Cytoskeletal Signaling MAPK Metabolism PI3K/Akt/mTOR signaling Stem Cells CDK S6 Kinase Casein Kinase SGK ROCK Serum and glucocorticoid-regulated kinase inhibit nestin S6K Inhibitor CK1 CKI 7 2HCl CKI-7 dihydrochloride CKI 7 Ribosomal S6 Kinase (RSK) CKI7 CKI 7 Dihydrochloride differentiation Cyclin dependent kinase CKI7 2HCl neural CKI 7 dihydrochloride Serum-glucocorticoid regulated kinase S6K1 MSK1 CKI7 dihydrochloride Wnt CKI-7 Dihydrochloride CKI-7 2HCl βIII-tubulin Sox1 CKI7 Dihydrochloride inhibitor

 

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