Shopping Cart

Your shopping cart is currently empty

Eudesmin

Name: Eudesmin
Brand: TargetMol
SKU: T3836
Price: 142 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T3836 Copy Product Info

Purity: 99.92%

😃Good

Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.50 microM (+)-eudesmin can induce neurite outgrowth and enhance nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells by stimulating up-stream MAPK, PKC and PKA pathways.

Eudesmin

Copy Product Info

😃Good

Catalog No. T3836

Cas No. 526-06-7

Pack Size	Price	USA Stock	Global Stock
1 mg	$142	In Stock	In Stock
5 mg	$355	In Stock	In Stock
10 mg	$526	In Stock	In Stock
25 mg	$838	In Stock	In Stock
50 mg	$1,130	In Stock	In Stock
100 mg	$1,520	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$470	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:99.92%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Eudesmin AI Summary

Eudesmin shows bioactivity primarily as an inhibitor of specific enzymes and signaling pathways. At a concentration of 2 mg/ml, it exhibits significant inhibition (20.43%) of acetylcholinesterase (AChE) in electric eels as determined by Ellman's method, but shows minimal inhibition (0.02%) of butyrylcholinesterase (BChE) in horses under the same conditions. Additionally, the compound inhibits the Wnt/beta-catenin signaling pathway in human HEK293 cells, showing a 26.3% inhibition in a dual luciferase reporter gene assay at 20 µM after 24 hours when compared to the vehicle-treated control. However, when tested for its ability to inhibit nitric oxide production induced by LPS in mouse RAW264.7 cells, Eudesmin exhibited an IC50 value greater than 50000 nM, indicating it has a weak or negligible effect in this context..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	386.44
Formula	C₂₂H₂₆O₆
Cas No.	526-06-7
Smiles	[H][C@@]12CO[C@@]([H])(c3ccc(OC)c(OC)c3)[C@]1([H])CO[C@@]2([H])c1ccc(OC)c(OC)c1
Relative Density.	1.173g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (64.69 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.18 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5877 mL	12.9386 mL	25.8772 mL	129.3862 mL
5 mM	0.5175 mL	2.5877 mL	5.1754 mL	25.8772 mL
10 mM	0.2588 mL	1.2939 mL	2.5877 mL	12.9386 mL
20 mM	0.1294 mL	0.6469 mL	1.2939 mL	6.4693 mL
50 mM	0.0518 mL	0.2588 mL	0.5175 mL	2.5877 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc