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PI3K/Akt/mTOR signaling mTOR LY-2584702 free base

LY-2584702 free base

Catalog No. T6159   CAS 1082949-67-4
Synonyms: LY2584702,

LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).

LY-2584702 free base, CAS 1082949-67-4
Pack Size Availability Price/USD Quantity
2 mg In stock 61.00
5 mg In stock 129.00
10 mg In stock 167.00
25 mg In stock 369.00
50 mg In stock 498.00
100 mg Inquiry 851.00
1 mL * 10 mM (in DMSO) In stock 140.00
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Purity 98.72%
Biological Description
Chemical Properties
Storage & Solubility Information
Description LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).
Targets&IC50 p70 S6K : ic50 4nM,  
In vivo LY2584702 (12.5 mg/kg BID), shows significant antitumor activity in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models. [1]
Synonyms LY2584702 ,
Purity 98.72%
Molecular Weight 445.42
Formula C21H19F4N7
CAS No. 1082949-67-4

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 1 mg/mL(2.24 mM), warmed

DMSO: 10 mM, warmed with 50ºC water bath

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Tolcher A, et al. Eur J Y. 2014, 50(5), 867-875. 1. Hollebecque A, Houédé N, Cohen EE, Massard C, Italiano A, Westwood P, Bumgardner W, Miller J, Brail LH, Benhadji KA, Soria JC. A phase Ib trial of LY2584702 tosylate, a p70 S6 inhibitor, in combination with erlotinib or everolimus in patients with solid tumours. Eur J Cancer. 2014 Mar;50(5):876-84. doi: 10.1016/j.ejca.2013.12.006. Epub 2014 Jan 20. 2. Hollebecque A , Houédé, Nadine, Cohen E E W , et al. A phase Ib trial of LY2584702 tosylate, a p70 S6 inhibitor, in combination with erlotinib or everolimus in patients with solid tumours.[J]. European Journal of Cancer, 2014, 50(5):876-884.

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JR-AB2-011 PQR-530 TMBIM6 antagonist-1 DMH-25 LY-2584702 free base N6-Cyclopentyladenosine 9,9'-Di-O-(E)-feruloylsecoisolariciresinol FT-1518

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