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PF-4708671

Catalog No. T2002   CAS 1255517-76-0
Synonyms: PF4708671

PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) .In cell-free assays, PF-4708671(PF4708671) is potent for S6K1(Ki50=20 nM, IC50=160 nM).

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PF-4708671 Chemical Structure
PF-4708671, CAS 1255517-76-0
Pack Size Availability Price/USD Quantity
5 mg In stock $ 47.00
10 mg In stock $ 70.00
25 mg In stock $ 113.00
50 mg In stock $ 153.00
100 mg In stock $ 279.00
1 mL * 10 mM (in DMSO) In stock $ 77.00
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Purity: 99.67%
Purity: 99.41%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) .In cell-free assays, PF-4708671(PF4708671) is potent for S6K1(Ki50=20 nM, IC50=160 nM).
Targets&IC50 p70 S6K1:160 nM
Kinase Assay Affinity determination: Purified activated FAK kinase domain (amino acids 410–689) is reacted with 50 μM ATP, and 10 μg/well of a random peptide polymer of Glu and Tyr (molar ratio of 4:1), poly(Glu/Tyr) in kinase buffer (50 mM HEPES, pH 7.5, 125 mM NaCl, 48 mM MgCl2) for 15 min. Phosphorylation of poly(Glu/Tyr) is challenged with serially diluted compounds at 1/2-Log concentrations starting at a top concentration of 1 μM. Each concentration is run in triplicate. Phosphorylation of poly(Glu/Tyr) is detected with a general anti-phospho-tyrosine (PY20) antibody, followed by horseradish peroxidase-conjugated goat anti-mouse IgG antibody. The standard horseradish peroxidase substrate 3, 3', 5, 5'-tetramethylbenzidine is added, and Optical Density readings at 450 nm are obtained following the addition of stop solution (2 M H2SO4). The IC50 values are determined using the Hill slope model.
Synonyms PF4708671
Molecular Weight 390.41
Formula C19H21F3N6
CAS No. 1255517-76-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 19.5 mg/mL (50 mM)

Ethanol: 19.5 mg/mL (50 mM)

TargetMolReferences and Literature

1. Pearce LR, et al. Biochem J, 2010, 431(2), 245-255.

Related compound libraries

This product is contained In the following compound libraries:
MAPK Inhibitor Library Inhibitor Library PI3K-AKT-mTOR Compound Library Metabolism Compound Library HIF-1 Signaling Pathway Compound Library Anti-Lung Cancer Compound Library Anti-Cancer Compound Library Anti-Cancer Metabolism Compound Library Stem Cell Differentiation Compound Library Antioxidant Compound Library

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Keywords

PF-4708671 1255517-76-0 Autophagy MAPK PI3K/Akt/mTOR signaling S6 Kinase inhibit S6K Inhibitor PF4708671 Ribosomal S6 Kinase (RSK) PF 4708671 inhibitor

 

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