Powder: -20°C for 3 years
In solvent: -80°C for 2 years
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
Description | AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II. |
Targets&IC50 | p70S6K:8 nM, ROCK1:6 nM, ROCK2:4 nM, PKA:3 nM, Akt1:38 nM |
Kinase Assay | In vitro kinase assays: AT13148 is assayed against 40 kinases and the percentage inhibition at 10 μM of AT13148 is determined. Individual IC50 values are measured for selected kinases using ATP concentrations equivalent to the Km for each enzyme. |
Cell Research | Cytotoxicity is determined using a 72 h Alamar Blue assay or a 96 h SRB assay. (Only for Reference) |
Molecular Weight | 313.79 |
Formula | C17H16ClN3O |
CAS No. | 1056901-62-2 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
H2O: <1 mg/mL
Ethanol: <1 mg/mL
DMSO: 58 mg/mL (184.8 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AT13148 1056901-62-2 MAPK信号通路 PI3K/Akt/mTOR信号通路 代谢 蛋白酪氨酸激酶 干细胞 细胞骨架 细胞周期 Akt PKA SGK ROCK S6 Kinase inhibit AT 13148 Protein kinase B S6K PKB AT-13148 ROK Protein kinase A Rho-associated protein kinase Rho-associated kinase Ribosomal S6 Kinase (RSK) Rho-kinase Inhibitor inhibitor