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AT13148

AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.

Catalog No. T2482Cas No. 1056901-62-2

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Purity:99%

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COA HNMR HPLC

AT13148

Catalog No. T2482Cas No. 1056901-62-2

AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$41	In Stock
2 mg	$57	In Stock
5 mg	$116	In Stock
10 mg	$196	In Stock
25 mg	$348	In Stock
50 mg	$505	In Stock
1 mL x 10 mM (in DMSO)	$129	In Stock

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Product Introduction

Bioactivity

Description	AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
Targets&IC50	ROCK1:6 nM, ROCK2:4 nM, p70 S6K:8 nM, PKA:3 nM, Akt1:38 nM
Kinase Assay	In vitro kinase assays: AT13148 is assayed against 40 kinases and the percentage inhibition at 10 μM of AT13148 is determined. Individual IC50 values are measured for selected kinases using ATP concentrations equivalent to the Km for each enzyme.
Cell Research	Cytotoxicity is determined using a 72 h Alamar Blue assay or a 96 h SRB assay. (Only for Reference)

Chemical Properties

Molecular Weight	313.78
Formula	C₁₇H₁₆ClN₃O
Cas No.	1056901-62-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 58 mg/mL (184.8 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1869 mL	15.9347 mL	31.8695 mL	159.3473 mL
5 mM	0.6374 mL	3.1869 mL	6.3739 mL	31.8695 mL
10 mM	0.3187 mL	1.5935 mL	3.1869 mL	15.9347 mL
20 mM	0.1593 mL	0.7967 mL	1.5935 mL	7.9674 mL
50 mM	0.0637 mL	0.3187 mL	0.6374 mL	3.1869 mL
100 mM	0.0319 mL	0.1593 mL	0.3187 mL	1.5935 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc