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BRD7389

BRD7389
BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
Catalog No. T14779Cas No. 376382-11-5
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Purity:99.17%
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BRD7389

Catalog No. T14779Cas No. 376382-11-5
BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
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Pack SizePriceAvailabilityQuantity
2 mg$29In Stock
5 mg$46In Stock
10 mg$64In Stock
25 mg$98In Stock
50 mg$148In Stock
100 mg$218In Stock
1 mL x 10 mM (in DMSO)$55In Stock
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Product Introduction

Bioactivity
Description
BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
Targets&IC50
SGK:13.8 μM, RSK2:2.4 μM, RSK1:1.5 μM, RSK3:1.2 μM, FLT3:3.5 μM, CDK5-p35:6.5 μM, DRAK1:2.8 μM, PKG1α:6.5 μM, Pim1:3.7 μM
In vitro
BRD7389 (1 μM) almost completely blocked Carbachol (1 mM)-stimulated cell proliferation, but has little effect on the basal level of proliferation[1]. BRD7389 (0.425, 0.85, 1.7, 3.4, 6.8 μM) induces insulin expression in mouse α-cells and induces a dose-dependent up-regulation of insulin (Ins2) mRNA, peaking at 0.85 μM. BRD7389 increases β-cell-specific gene expression in primary human islet cells. BRD7389 (0.85-6.8μM) significantly up-regulates Pdx1 mRNA expression in mouse α-cell line[2].
Chemical Properties
Molecular Weight366.41
FormulaC24H18N2O2
Cas No.376382-11-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 20 mg/mL (54.58 mM), Sonication and heating to 60℃ are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7292 mL13.6459 mL27.2918 mL136.4592 mL
5 mM0.5458 mL2.7292 mL5.4584 mL27.2918 mL
10 mM0.2729 mL1.3646 mL2.7292 mL13.6459 mL
20 mM0.1365 mL0.6823 mL1.3646 mL6.8230 mL
50 mM0.0546 mL0.2729 mL0.5458 mL2.7292 mL

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