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BRD7389

Catalog No. T14779   CAS 376382-11-5

BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.

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BRD7389 Chemical Structure
BRD7389, CAS 376382-11-5
Pack Size Availability Price/USD Quantity
5 mg In stock $ 77.00
10 mg In stock $ 106.00
25 mg In stock $ 169.00
50 mg In stock $ 247.00
100 mg In stock $ 364.00
1 mL * 10 mM (in DMSO) In stock $ 91.00
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Purity: 99.17%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
Targets&IC50 FLT3:3.5 μM, RSK3:1.2 μM, CDK5-p35:6.5 μM, Pim1:3.7 μM, DRAK1:2.8 μM, PKG1α:6.5 μM, SGK:13.8 μM, RSK2:2.4 μM, RSK1:1.5 μM
In vitro BRD7389 (1 μM) almost completely blocked Carbachol (1 mM)-stimulated cell proliferation, but has little effect on the basal level of proliferation[1]. BRD7389 (0.425, 0.85, 1.7, 3.4, 6.8 μM) induces insulin expression in mouse α-cells and induces a dose-dependent up-regulation of insulin (Ins2) mRNA, peaking at 0.85 μM. BRD7389 increases β-cell-specific gene expression in primary human islet cells. BRD7389 (0.85-6.8μM) significantly up-regulates Pdx1 mRNA expression in mouse α-cell line[2].
Molecular Weight 366.41
Formula C24H18N2O2
CAS No. 376382-11-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL (54.58 mM), Sonification and heating to 60℃ are recommended.

TargetMolReferences and Literature

1. Park YS, et al. EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-407 colon cancer cells by muscarinic acetylcholine receptors. Mol Cell Biochem. 2012 Nov;370(1-2):191-8. 2. Fomina-Yadlin D, et al. Small-molecule inducers of insulin expression in pancreatic alpha-cells. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15099-104.

Related compound libraries

This product is contained In the following compound libraries:
Tyrosine Kinase Inhibitor Library Inhibitor Library Metabolism Compound Library Anti-Cancer Metabolism Compound Library Anti-Breast Cancer Compound Library Anti-Lung Cancer Compound Library Epigenetics Compound Library Anti-Pancreatic Cancer Compound Library Anti-Obesity Compound Library Bioactive Compound Library

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EMD638683 SI-113 AT13148 EMD638683 R-Form CKI-7 PROTAC SGK3 degrader-1 URMC-099 GSK 650394

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Keywords

BRD7389 376382-11-5 Angiogenesis Apoptosis Cell Cycle/Checkpoint Chromatin/Epigenetic JAK/STAT signaling MAPK Metabolism PI3K/Akt/mTOR signaling Tyrosine Kinase/Adaptors CDK DAPK S6 Kinase FLT Pim SGK cancer S6K Inhibitor colon BRD 7389 inhibit RSK islets diabetes pancreatic SNU-407 BRD-7389 Ribosomal S6 Kinase (RSK) inhibitor

 

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