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Pluripotin

Catalog No. T6948 CAS 839707-37-8

Synonyms: SC1

Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP.

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Pluripotin, CAS 839707-37-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 30.00
2 mg	In stock	$ 43.00
5 mg	In stock	$ 61.00
10 mg	In stock	$ 85.00
25 mg	In stock	$ 150.00
50 mg	In stock	$ 231.00
100 mg	In stock	$ 369.00
1 mL * 10 mM (in DMSO)	In stock	$ 72.00

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Purity: 98.77%

Biological Description

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Description	Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP.
Targets&IC50	ERK1:98 nM(Kd), RasGAP:212 nM(Kd)
In vitro	SC1 is a dual function small molecule inhibitor of both ERK1 and RasGAP and that simultaneous inhibition of both protein activities is required and sufficient for SC1's effects on mES cells. SC1 activates Ras by inhibition of RasGAP function[1]. SC1 improved the derivation efficiency and pluripotency of ES cells from C57BL/6. Three types of pluripotent stem cells (fES, ntES, and iPS cells) of the C57BL/6 background could generate full-term pups with high efficiency when cultured with SC1[1].

Synonyms	SC1
Molecular Weight	550.53
Formula	C27H25F3N8O2
CAS No.	839707-37-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 13.8 mg/mL (25 mM)

References and Literature

1. Chen S, et al. Proc Natl Acad Sci U S A. 2006, 103(46):17266-17271. 2. Lin CJ, et al. PLoS One. 2014, 9(9):e106916.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Obesity Compound Library Stem Cell Differentiation Compound Library Bioactive Compound Library MAPK Inhibitor Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pluripotin 839707-37-8 MAPK PI3K/Akt/mTOR signaling Raf ERK S6 Kinase inhibit Extracellular signal regulated kinases Ribosomal S6 Kinase (RSK) Inhibitor SC-1 SC1 S6K SC 1 inhibitor

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