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Carnosol

Name: Carnosol
Brand: TargetMol
SKU: T6S1302
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6S1302Cas No. 5957-80-2

Carnosol is an Nrf2 activator, increasing Nrf2 levels and promoting heme oxygenase 1 (HMOX1) expression. It is a ribosomal S6 kinase (RSK2) inhibitor and can be used in gastric cancer-related research with an IC50 value of approximately 5.5 μM.

Carnosol

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Purity: 99.83%

Catalog No. T6S1302Cas No. 5957-80-2

Pack Size	Price	Availability
5 mg	$39	In Stock
10 mg	$55	In Stock
25 mg	$113	In Stock
50 mg	$168	In Stock
100 mg	$249	In Stock
500 mg	$613	Backorder

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Purity:99.83%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Carnosol is an Nrf2 activator, increasing Nrf2 levels and promoting heme oxygenase 1 (HMOX1) expression. It is a ribosomal S6 kinase (RSK2) inhibitor and can be used in gastric cancer-related research with an IC50 value of approximately 5.5 μM.
Targets&IC50	RSK2:5.5 μM.

Chemical Properties

Molecular Weight	330.42
Formula	C₂₀H₂₆O₄
Cas No.	5957-80-2
Smiles	CC(C)c1cc2[C@H]3C[C@H]4C(C)(C)CCC[C@@]4(C(=O)O3)c2c(O)c1O
Relative Density.	1.26 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (181.59 mM), Sonication is recommended.

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0265 mL	15.1323 mL	30.2645 mL	151.3226 mL
5 mM	0.6053 mL	3.0265 mL	6.0529 mL	30.2645 mL
10 mM	0.3026 mL	1.5132 mL	3.0265 mL	15.1323 mL
20 mM	0.1513 mL	0.7566 mL	1.5132 mL	7.5661 mL
50 mM	0.0605 mL	0.3026 mL	0.6053 mL	3.0265 mL
100 mM	0.0303 mL	0.1513 mL	0.3026 mL	1.5132 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc