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Carnosol

Name: Carnosol
Brand: TargetMol
SKU: T6S1302
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6S1302Cas No. 5957-80-2

Carnosol is an Nrf2 activator, increasing Nrf2 levels and promoting heme oxygenase 1 (HMOX1) expression. It is a ribosomal S6 kinase (RSK2) inhibitor and can be used in gastric cancer-related research with an IC50 value of approximately 5.5 μM.

Carnosol

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Purity: 99.83%

Catalog No. T6S1302Cas No. 5957-80-2

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$55	In Stock	In Stock
25 mg	$113	In Stock	In Stock
50 mg	$168	-	In Stock
100 mg	$249	-	In Stock
500 mg	$613	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.83%

Color:White

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COA HNMR LCMS

Product Introduction

Carnosol AI Summary

Carnosol is a versatile bioactive molecule with several significant properties. It inhibits pancreatic lipase with an IC50 value of 13000 nM and HIV1 recombinant protease expressed in Escherichia coli BL21 (DE3) cells with an IC90 value greater than 10 µg/mL. The compound demonstrates antioxidant activity by scavenging DPPH free radicals, showing an IC50 value of 114000 nM. It also exhibits cytotoxicity against various human cancer cell lines, such as A2780, SW1573, WiDr, T47D, and HBL100, with GI50 values ranging from 3600 nM to 26000 nM after 48 hours of exposure. Furthermore, Carnosol shows antibacterial activity against Bacillus subtilis, Staphylococcus epidermidis, Staphylococcus aureus, Bacillus cereus, and Candida albicans. It activates the Nrf2/ARE pathway in E15 stage mouse primary cortical neurons, eliciting a 50-fold change in activity at a concentration of 25 µM after 48 hours. Additionally, the compound is an effective inhibitor of microsomal PGES1 in ILbeta-stimulated human A549 cells, with an IC50 value of 5000 nM, and inhibits human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS with an IC50 value of 13300 nM. It also exhibits strong antibiofilm activities against Staphylococcus aureus and Pectobacterium carotovorum, and moderate inhibition against Listeria monocytogenes and Acinetobacter baumannii, although it shows no significant antibiofilm activity against Escherichia coli..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Carnosol is an Nrf2 activator, increasing Nrf2 levels and promoting heme oxygenase 1 (HMOX1) expression. It is a ribosomal S6 kinase (RSK2) inhibitor and can be used in gastric cancer-related research with an IC50 value of approximately 5.5 μM.
Targets&IC50	RSK2:5.5 μM.

Chemical Properties

Molecular Weight	330.42
Formula	C₂₀H₂₆O₄
Cas No.	5957-80-2
Smiles	CC(C)c1cc2[C@H]3C[C@H]4C(C)(C)CCC[C@@]4(C(=O)O3)c2c(O)c1O
Relative Density.	1.26 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (181.59 mM), Sonication is recommended.

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.05 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0265 mL	15.1323 mL	30.2645 mL	151.3226 mL
5 mM	0.6053 mL	3.0265 mL	6.0529 mL	30.2645 mL
10 mM	0.3026 mL	1.5132 mL	3.0265 mL	15.1323 mL
20 mM	0.1513 mL	0.7566 mL	1.5132 mL	7.5661 mL
50 mM	0.0605 mL	0.3026 mL	0.6053 mL	3.0265 mL
100 mM	0.0303 mL	0.1513 mL	0.3026 mL	1.5132 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc