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Cat No. | Product Name | Synonyms | Targets |
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T14007 | PAF-AN-1 | PAFR | |
PAF-AN-1 is a novel potent platelet-activating factor receptor (PAF) antagonist involved in the study of anaphylactic death. | |||
T21547 | PAF (C16) | C16-PAF | ERK , MEK , MAPK , Endogenous Metabolite |
PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability. PAF (C16) (PAF (C16)) is a platelet-activating factor, a phospholipid-derived mediator and a ligand for PAF G protein-coupled... | |||
T36180 | Azelaoyl PAF | ||
Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPARγ. One of these substances was recently isolated and pur... | |||
T36764 | PAF C-18:1 | ||
PAF C-18:1 is a naturally occurring phospholipid produced by cells upon stimulation and plays a role in the establishment and maintenance of the inflammatory response. It is less potent than PAF C-16 and PAF C-18 in the ... | |||
T36763 | PAF C-18 | ||
PAF C-18 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the remodeling" and 'de novo' pathways. It is less potent than PAF C-16 in the induction of platelet aggrega... | |||
T36205 | Methylcarbamyl PAF C-16 | ||
Methylcarbamyl PAF C-16 is a stable analog of PAF C-16 with a half-life greater than 100 minutes in platelet poor plasma due to its resistance to degradation by PAF-AH. It is nearly equipotent with PAF C-16 in its abilit... | |||
T37268 | PAF C-16 Carboxylic Acid | ||
PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the remodeling" and 'de novo' pathways. It is a potent mediator of neutrophil migration and the production o... | |||
T19104 | 2-Thio-PAF | Others | |
2-Thio-PAF is a synthetic analog of PAF used in a colorimetric assay for PAF acetylhydrolase. | |||
T29308 | Lyso-PAF C-16 | ||
Lyso-PAF C-16 is a biologically inactive precursor of platelet activating factor. | |||
T6242 | Rupatadine Fumarate | Rinialer,Rupafin,Alergoliber | PAFR , Autophagy , Histamine Receptor |
Rupatadine Fumarate (Rinialer) (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM. | |||
T15338 | Foropafant | SR27417 | Others , Platelet aggregation |
Foropafant (SR27417) is a highly potent and selective platelet-activating factor (PAF) receptor antagonist (Ki: 57 pM). Foropafant potently inhibits the PAF-induced aggregation of rabbit and human platelets. | |||
T28607 | Rocepafant | LAU 8080,LAU8080,BN 50730,LAU-8080,BN50730,BN-50730 | Platelet aggregation |
Rocepafant (LAU8080) is a platelet-activating factor (PAF) antagonist that attenuates hypoxic-ischemic brain damage in neonatal rats.Rocepafant inhibits tumor necrosis factor-Afa-mediated cytotoxicity in mouse L929 tumor... | |||
T9445 | Vepafestinib | c-RET | |
Vepafestinib is a RET inhibitor with potential antineoplastic activity[1]. | |||
T68124 | Pafenolol | Adrenergic Receptor , P-gp | |
Pafenolol is a P-glycoprotein modulator with a Ki value of 5.5 µM. pafenolol is an orally available and selective beta-adrenergic receptor antagonist. | |||
T6955 | Propafenone hydrochloride | Propafenone HCl,Arythmol,SA-79 (hydrochloride),Rytmonorm,Rythmol | Sodium Channel |
Propafenone hydrochloride (Arythmol8) is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias. | |||
T1280 | Nepafenac | AL 6515,AHR 9434 | COX |
Nepafenac (AHR 9434) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of nepafenac is as a Cyclooxygenase Inhibitor. The chemical classification of nepafenac is Nonsteroidal Anti-inflammatory Compounds. | |||
T0866 | Propafenone | Rythmol,Propafenonum | Potassium Channel , MRP , Sodium Channel |
Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.... | |||
T14300 | Apafant | WEB 2086 | Others |
Apafant is a potent antagonist of platelet-activating factor (PAF), inhibits PAF binding to human PAF receptors(Ki : 9.9 nM). | |||
T27821 | Lexipafant | ISV-611,GR-167089,DO-6,BB-882,DO6,BB882 | |
Lexipafant is a platelet-activating factor (PAF) receptor antagonist. | |||
T33466 | Modipafant | ||
Modipaafant is a potent dihydropyridine PAF (platelet activating factor) antagonist. | |||
T28081 | (Rac)-Modipafant | UK-74505,Modipafant racemate,UK74505,UK 74505 | |
Modipafant racemate is a potent and specific oral platelet activating factor (PAF) receptor antagonist. | |||
T17178 | Tulopafant | RP 59227 | PAFR |
Tulopafant (RP 59227) is a potent platelet-activating factor (PAF) antagonist that increases capillary patency and prolongs allograft heart survival. | |||
T26775 | Bepafant | WEB-2170,WEB2170,STY 2108,STY-2108,WEB 2170 | |
Bepafant is a platelet activating factor (PAF) antagonist. Bepafant may produce significant anti-inflammatory effects. Bepafant triggered apoptosis in NB4, KG1, and NB4-MR4 cells where PTEN was expressed, but not in THP1... | |||
T27638 | Israpafant | Y-24180,Y 24180,Y24180 | |
Israpafant is a selective antagonist for the platelet-activating factor receptor ( IC50 = 0.84nM). Israpafant inhibits PAF-induced human platelet aggregation. Israpafant inhibits the activation of eosinophil cells and co... | |||
T20840 | Apaflurane | FM200,FM-200,FM 200 | |
Apaflurane is a chemical fire extinguishing agent. | |||
T12548 | Propafenone D7 hydrochloride | SA-79 (D7 hydrochloride) | Others |
Propafenone D7 hydrochloride is the deuterium labeled Propafenone, and is a classic anti-arrhythmic medication. | |||
T39103 | Pafolacianine | OTL 38 | |
Pafolacianine (OTL 38) is a near-infrared dye-based fluorescent marker utilized for identifying ovarian cancer lesions during surgeries. | |||
T80312 | PAF26 | ||
PAF26 is an antimicrobial peptide that exhibits efficacy against phytopathogenic fungi, including Penicillium digitatum, Penicillium italicum, and Botrytis cinerea [1]. | |||
T81112 | SPPHPSPAFSPAFDNLYYWDQ | ||
SPPHPSPAFSPAFDNLYYWDQ is a multi-epitope class II rat HER2/neu peptide applicable in the investigation of class II HER2-DC1 vaccine studies [1]. | |||
T12811 | (S)-Propafenone | (S)-SA-79 | Others |
(S)-Propafenone ((S)-SA-79) is the S-enantiomer of Propafenone. It possesses beta-blocking properties and exhibits class 1 antiarrhythmic activity reliant on sodium channel blockade. | |||
T68101 | Minopafant | ||
minopafant is a useful organic compound for research related to life sciences. The catalog number is T68101 and the CAS number is 790174-16-2. | |||
T31996 | Grepafloxacin Hydrochloride | DSSTox_CID_26692,OPC-17116,DSSTox_RID_81826,DSSTox_GSID_46692 | |
Grepafloxacin Hydrochloride is an antimicrobial agent, oral broad-spectrum fluoroquinolone. It is used to treat bacterial infections. | |||
T25461 | Grepafloxacin, (S)- | L-Grepafloxacin | |
Grepafloxacin, (S)- is an oral broad-spectrum fluoroquinolone antibacterial used for the treatment of bacterial infections. | |||
T23951 | Dacopafant | UNII-H1T03Z1G60 | |
Dacopafant is an antagonist of platlet activationg factor receptor. | |||
T81111 | SPPHPSPAFSPAFDNLYYWDQ TFA | ||
SPPHPSPAFSPAFDNLYYWDQ TFA is a multi-epitope, class II rat HER2/neu peptide designed for research on the class II HER2-DC1 vaccine [1]. | |||
T19153 | 5-Hydroxy Propafenone D5 Hydrochloride | GPV-129 D5 Hydrochloride | Others |
5-Hydroxy Propafenone D5 HCl is the deuterium labeled 5-Hydroxy Propafenone. | |||
T16874 | Setipafant | BN-50727,LAU-0901 | Others |
Setipafant is an antagonist of the platelet-activating factor. | |||
T16428 | Pafuramidine | DB289 | Others |
Pafuramidine is an orally bioavailable prodrug of furamidine. It has activity against Pneumocystis pneumonia (IC50 value: 4.5 nM) | |||
T38586 | Grepafloxacin | dl-Grepafloxacin,OPC-17116 | |
Grepafloxacin (OPC-17116) is a fluoroquinolone antibiotic that is administered orally. It possesses strong efficacy against community-acquired respiratory pathogens, notably Streptococcus pneumonia. Grepafloxacin exhibit... | |||
T77039 | Ipafricept | ||
Ipafricept (OMP-54F28; FZD8-Fc), a pioneering recombinant fusion protein, incorporates the extracellular segment of the human frizzled-8 receptor and the Fc fragment of human IgG1, targeting the Wnt ligand. It exhibits a... | |||
T81270 | Ripafollitropin alfa (bovine) | ||
Ripafollitropin alfa (bovine) is a fusion protein that combines recombinant follicle-stimulating hormone with chorionic gonadotropin [1]. | |||
T12208 | Nepafenac-d5 | AHR-9434 D5,AL-6515 D5 | Others |
Nepafenac D5 is the deuterium labeled Nepafenac, which is a selective inhibitor of COX-2 . | |||
T24586 | PAFAH1b2 | PAFAH-1-b-2,3-IN-P11,3INP11,3 IN P11,PAFAH 1 b 2 | |
PAFAH1b2 is a selective platelet-activating factor acetylhydrolases 1b2 and 1b3 inhibitor that acts by impairing cancer cell survival. | |||
T24587 | Pafuramidine maleate | DB-289,DB289,DB 289 | |
Pafuramidine is an orally bioavailable prodrug of formamidine which was developed for the treatment of human African trypanosomiasis. | |||
T70999 | Aspafilioside B | ||
Aspafilioside B is a steroidal saponin extracted from Asparagus filicinus that inhibits the growth and proliferation of HCC cell lines. | |||
T19686 | SCH-37370 | Platelet aggregation | |
SCH-37370 is an effective and orally active dual antagonist of platelet-activating factor and histamine. Sch 37370 blocks the binding of [3H]pyrilamine to histamine-H1 receptors in rat brain membranes. Sch 37370 selectiv... | |||
T27102 | CV-6209 | ||
CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor. | |||
T27159 | DF-1111301 | DF1111301,DF 1111301 | Platelet aggregation , Histamine Receptor |
DF-1111301 is a novel anti-allergic compound with anti-histamine H1 and anti-PAF activity. | |||
T4511 | ST271 | ST 271 | Phospholipase , Tyrosine Kinases |
ST271 is an effective protein tyrosine kinase (PTK) inhibitor. | |||
T10873 | CP-96486 | Others | |
CP-96486 is a potent and orally active antagonist of leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor (Kis: 20 and 24 nM). |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN4222 | Homoeriodictyol 7-O-β-D-glucoside | Homoeriodictyol 7-O-glucoside | Others , Platelet aggregation |
Homoeriodictyol 7-O-β-D-glucoside (Homoeriodictyol 7-O-glucoside) is a natural product from Viscum coloratum(Kom.)Nakai. Homoeriodictyol 7-O-β-D-glucoside is an antagonist of platelet-activating factor (PAF). | |||
T30170 | Aspafilioside A | ||
Aspafilioside A is a steroidal saponin isolated from the root of Asparagus filicinus. | |||
TN1170 | 1-Cinnamoylpyrrolidine | Platelet aggregation | |
1-Cinnamoylpyrrolidine, a natural product prepared from Piper caninum, can be used as a DNA strand breaking agent, inducing the relaxation of the plasmid pBR322 DNA superhelix in the presence of Cu2+. 1-Cinnamoylpyrrolid... | |||
TN2322 | Yangambin | Calcium Channel , PAFR | |
Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peripheral vasodilatation that involves, at least, the inhibiti... | |||
T2749 | Ginkgolide A | BN-52020 | GABA Receptor , Endogenous Metabolite |
Ginkgolide A (BN-52020) is a highly active PAF antagonist cage molecule that is isolated from the leaves of the Ginkgo biloba tree. Shows potential in a wide variety of inflammatory and immunological disorders. | |||
T7030 | Anemarsaponin B | p38 MAPK , NF-κB , MEK , COX , NO Synthase | |
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity, possibly via the p38 MAP kinase pathway. Anemarsaponin B c... | |||
TN3161 | 6-Deoxyjacareubin | Antioxidant , PAFR , Platelet aggregation , Antifection | |
6-Deoxyjacareubin exhibits potent antioxidant and antifungal activities. 6-Deoxyjacareubin inhibits platelet activating factor (PAF) receptor with an IC50 of 29.0 microM and can be used in studies about natural PAF recep... | |||
TN2763 | 2-Hydroxy-3-methoxybenzoic acid glucose ester | PAFR | |
2-Hydroxy-3-methoxybenzoic acid glucose ester shows a potent antagonistic activity against platelet activating factor (PAF), it can prevent the mice from the PAF-induced death at a dose of 300 micrograms/mouse. | |||
TN5045 | Spiradine F | PAFR | |
Spiradine F can significantly inhibit platelet-activating factor(PAF)-induced platelet aggregation in a concentration-dependent manner. | |||
TN4795 | Piperenone | PAFR | |
Piperenone is an insect antifeeding substance. It has anti-platelet-activating factor(PAF) activities, is a PAF-acether antagonist. | |||
TN3520 | Bisdethiobis(methylthio)gliotoxin | PAFR | |
Bisdethiobis(methylthio)gliotoxin is a platelet activating factor (PAF) antagonist. | |||
T13716 | (+)-Guaiacin | Others | |
(+)-Guaiacin is a compound isolated from the bark of Machilus wangchiana Chun. It shows potent in vitro activities against the release of β-glucuronidase in rat polymorphonuclear leukocytes (PMNs) induced by platelet-act... | |||
TN4181 | Hancinone C | PAFR | |
Hancinone C shows inhibitory activity against the platelet aggregation caused by PAF. | |||
T68233 | Kadsurenone | ||
Kadsurenone is a platelet-activating factor receptor antagonist from Chinese herbal plant, haifenteng. It is a useful and promising treatment strategy for breast cancer bone metastases by blocking the PAF/PTAFR signaling... | |||
TN4821 | Pregomisin | PAFR | |
Pregomisin shows platelet-activating factor (PAF) antagonistic activity and the IC 50 value is 4.8x10(-5) M. | |||
T83460 | 11-O-β-D-glucopyranosyl thamnosmonin | ||
11-O-β-D-glucopyranosyl thamnosmonin is a coumarin glucoside extractable from the roots of Angelica apaensis that exhibits weak inhibitory effects on rabbit platelet aggregation induced by PAF, AA, and ADP [1]. | |||
TN4794 | Pinusolidic acid | PAFR | |
Pinusolidic acid shows a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets (IC50 = 2.3 x 10(-5) M, 7.48 +/- 2.11 micrograms/ml). | |||
T79948 | Kadsurenin B | ||
Kadsurenin B, a platelet-activating factor (PAF) antagonist, exhibits neuroprotective properties and has a broad spectrum of pharmacological research applications, including antibacterial, anti-inflammatory, neuroprotect... | |||
TN1815 | Kadsulignan L | HBV , PAFR | |
Kadsulignan L shows in vitro antiviral effects on hepatitis B virus. It also shows moderate platelet-activating factor (PAF) antagonistic activities with the IC50 value of 2.6 x 10(-5) M. | |||
TL0014 | Pinusolide | ERK , p38 MAPK , Calcium Channel , Lipoxygenase , PAFR , Caspase , JNK , AMPK | |
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, and could be used to treat neurodegenerative diseases. Pinus... | |||
T38015 | Herquline A | ||
Herquline A is an alkaloid fungal metabolite originally isolated from P. herquei. It inhibits cell death induced by influenza A strain A/PR/8/34 in MDCK cells with an IC50 value of 10 μg/ml and inhibits viral replication... | |||
TN6056 | Zanthobungeanine | 8-Methoxy-N-methylflindersine | |
Zanthobungeanine has anti-inflammatory activity, it shows moderate NO production inhibitory activity with an IC50 value of 37.26 mg /L.It shows obviously inhibitoryactivity to platelet aggregation caused by platelet-acti... | |||
TN3723 | Cryptomeridiol | PAFR , Antifection | |
Cryptomeridiol is a potential skin-whitening agent, exhibits melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells. Cryptomeridiol has low activity against A. niger, T. mentagrophytes, and C. albicans.... | |||
TN4088 | Futoenone | PAFR | |
Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicate the preferred binding of the P2' site of the enzymes. Neol... | |||
TN5414 | Wallichinine | ||
Wallichinine shows inhibitory activity on platelet aggregation caused by platelet activating factor (PAF). Wallichinine with ABCB1 presents valuable clues for the development of novel MDR reversal reagents from natural p... | |||
TN4664 | Norarmepavine | Others | |
N-norarmepavine shows significant cytotoxic activities against HL-60 carcinoma cell line with inhibitory ratios of 51.43% at concentration of 1 x 10(-5) M. Norarmepavine shows inhibition against Trypanosoma cruzi. D-(+)-... | |||
T38330 | Collinin | ||
Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Col... |
Cat No. | Product Name | Species | Expression System |
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TMPK-00835 | LCAT Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Lecithin:cholesterol acyltransferase (LCAT) is the only enzyme capable of esterifying cholesterol in plasma, thus determining the maturation of high-density lipoproteins. Because it maintains an unesterified cholesterol ... | |||
TMPY-02796 | KIAA0101 Protein, Human, Recombinant (His) | Human | E. coli |
KIAA11, also known as p15(PAF), is a proliferating cell nuclear antigen-associated factor that interacts with proliferating cell nuclear antigen(PCNA). It was initially isolated in a yeast two-hybrid screen for PCNA bind... | |||
TMPJ-01054 | PAFAHB Protein, Human, Recombinant (His) | Human | E. coli |
Platelet-Activating Factor Acetylhydrolase IB Subunit β (PAFAHB) is a cytoplasmic hydrolase. PAFAHB is a member of the GDSL lipolytic enzyme family. It also belongs to Platelet-activating factor acetylhydrolase IB beta/g... | |||
TMPJ-00553 | Lp-PLA2/PLA2G7 Protein, Human, Recombinant (aa 22-441, His) | Human | HEK293 Cells |
Platelet-Activating Factor Acetylhydrolase (PAFAH) is a secreted enzyme which belongs to the AB hydrolase superfamily and Lipase family and catalyzes the degradation of platelet-activating factor to biologically inactive... | |||
TMPJ-00020 | IL-5 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
IL-5 is expressed in eosinophils, NK cells, TC2 CD8+ T cells, mast cells, CD45+ CD4+ T cells, gamma delta T cells and IL-1 beta activated endothelial cells. IL-5 acts as a growth and differentiation factor for both B cel... | |||
TMPH-02690 | PLA2G10 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatid... |