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Tulopafant

Catalog No. T17178 CAS 116289-53-3

Synonyms: RP 59227

Tulopafant (RP 59227) is a potent platelet-activating factor (PAF) antagonist that increases capillary patency and prolongs allograft heart survival.

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Tulopafant, CAS 116289-53-3

Pack Size	Availability	Price/USD	Quantity
1 mg	In stock	$ 700.00
5 mg	In stock	$ 1,800.00

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Purity: 99.38%

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Chemical Properties

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Description	Tulopafant (RP 59227) is a potent platelet-activating factor (PAF) antagonist that increases capillary patency and prolongs allograft heart survival.
In vitro	Preincubation of neutrophils with Tulopafant (RP 59227) leads to a concentration-dependent reduction in chemiluminescence emitted by PAF-primed cells[2].
In vivo	Tulopafant (RP 59227) effectively reduces myocardial infarct size and decreases the incidence of ischemia and reperfusion-induced arrhythmias in barbital-anesthetized dogs[1]. Histological examination reveals a marked reduction in both interstitial hemorrhage and the deposition of platelets and granulocytes in capillaries of cardiac xenografts when recipient animals are pretreated with Tulopafant[1].

Synonyms	RP 59227
Molecular Weight	425.5
Formula	C25H19N3O2S
CAS No.	116289-53-3

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. O'Hair DP, et al. Tulopafant, a PAF receptor antagonist, increases capillary patency and prolongs survival in discordant cardiac xenotransplants. J Lipid Mediat. 1993 May;7(1):79-84. 2. Auchampach JA, et al. Effect of the platelet-activating factor antagonist RP 59227 (Tulopafant) on myocardial ischemia/reperfusion injury and neutrophil function. Basic Res Cardiol. 1998 Oct;93(5):361-71.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library

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Keywords

Tulopafant 116289-53-3 GPCR/G Protein PAFR RP 59227 RP59227 RP-59227 inhibitor inhibit

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