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Lexipafant

Catalog No. T27821 CAS 139133-26-9

Synonyms: ISV-611, GR-167089, DO-6, BB-882, DO6, BB882

Lexipafant is a platelet-activating factor (PAF) receptor antagonist.

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Lexipafant, CAS 139133-26-9

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,670.00
50 mg	6-8 weeks	$ 2,180.00
100 mg	6-8 weeks	$ 2,800.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Lexipafant is a platelet-activating factor (PAF) receptor antagonist.

Synonyms	ISV-611, GR-167089, DO-6, BB-882, DO6, BB882
Molecular Weight	458.57
Formula	C23H30N4O4S
CAS No.	139133-26-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Oztürk H, Oztürk H, Dokucu AI, Otcu S. Effects of lexipafant (BB-882), a platelet activating factor receptor antagonist, on liver damage due to bile duct ligation in rats. Acta Gastroenterol Belg. 2006 Apr-Jun;69(2):197-202. PubMed PMID: 16929615. 2. Aldemir M, Boşnak M, Al B, Büyükbayram H, Taçyildiz I. Effects of molsidomine and lexipafant in hepatic ischaemia--reperfusion injury. Injury. 2004 Mar;35(3):232-7. PubMed PMID: 15124788. 3. Johnson CD, Kingsnorth AN, Imrie CW, McMahon MJ, Neoptolemos JP, McKay C, Toh SK, Skaife P, Leeder PC, Wilson P, Larvin M, Curtis LD. Double blind, randomised, placebo controlled study of a platelet activating factor antagonist, lexipafant, in the treatment and prevention of organ failure in predicted severe acute pancreatitis. Gut. 2001 Jan;48(1):62-9. PubMed PMID: 11115824; PubMed Central PMCID: PMC1728186. 4. Börjesson A, Wang X, Sun Z, Inghammar M, Truedsson L, Andersson R. Early treatment with lexipafant, a platelet-activating factor-receptor antagonist, is not sufficient to prevent pulmonary endothelial damage after intestinal ischaemia and reperfusion in rats. Dig Liver Dis. 2002 Mar;34(3):190-6. PubMed PMID: 11990391.

Dose Conversion

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Lexipafant 139133-26-9 ISV-611 GR 167089 GR-167089 ISV611 ISV 611 BB 882 DO-6 BB-882 GR167089 DO 6 DO6 BB882 inhibitor inhibit

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