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Rocepafant

Catalog No. T28607 CAS 132579-32-9

Synonyms: LAU 8080, LAU8080, BN 50730, LAU-8080, BN50730, BN-50730

Rocepafant (LAU8080) is a platelet-activating factor (PAF) antagonist that attenuates hypoxic-ischemic brain damage in neonatal rats.Rocepafant inhibits tumor necrosis factor-Afa-mediated cytotoxicity in mouse L929 tumor cells.

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Rocepafant, CAS 132579-32-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 76.00
5 mg	In stock	$ 177.00
10 mg	In stock	$ 260.00
25 mg	In stock	$ 506.00
50 mg	In stock	$ 690.00
100 mg	In stock	$ 982.00

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Purity: 99.38%

Purity: 99.23%

Biological Description

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Storage & Solubility Information

Description	Rocepafant (LAU8080) is a platelet-activating factor (PAF) antagonist that attenuates hypoxic-ischemic brain damage in neonatal rats.Rocepafant inhibits tumor necrosis factor-Afa-mediated cytotoxicity in mouse L929 tumor cells.
Targets&IC50	PAF receptor:0.74 nM
In vivo	Ten patients with active disease were treated for 4 weeks with a PAF receptor antagonist, BN 50730, given orally (40 mg twice daily). The treatment period was followed by a 4-week follow-up period. Clinical indicators of disease activity significantly improved during the treatment period, with a progressive return to baseline values during the follow-up period. No significant change in laboratory variables was observed. The tolerance of the treatment was excellent, and no clinical or laboratory evidence of side effects was recorded. These results must be confirmed in a controlled study, but suggest an anti-inflammatory effect.[4]

Synonyms	LAU 8080, LAU8080, BN 50730, LAU-8080, BN50730, BN-50730
Molecular Weight	535.08
Formula	C26H23ClN6OS2
CAS No.	132579-32-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Liu XH, et al. Platelet-activating factor antagonist BN 50730 attenuates hypoxic-ischemic brain injury in neonatal rats. Pediatr Res. 2001 Jun;49(6):804-1 2. Singh N, et al. Effects of BN-50730 (PAF receptor antagonist) and physostigmine (AChE inhibitor) on learning and memory in mice. Methods Find Exp Clin Pharmacol. 1997 Nov;19(9):585-8. 3. Silva CL, et al. Formation of a highly stable complex between BN 50730 [tetrahydro-4,7,8,10 methyl-1(chloro-2 phenyl)-6 (methoxy-4 phenyl-carbamoyl)-9 pyrido [4',3'-4,5] thieno [3,2-f] triazolo-1,2,4 [4,3-a] diazepine-1,4] and the platelet-activating factor receptor in rabbit platelet membranes. Biochem Pharmacol. 1996 Jan 26;51(2):193-6. 4. Hilliquin P, et al. Treatment of rheumatoid arthritis with platelet activating factor antagonist BN 50730. J Rheumatol. 1995 Sep;22(9):1651- 5. Pires AL, et al. Long-lasting inhibitory activity of the hetrazepinic BN 50730 on exudation and cellular alterations evoked by PAF and LPS. Br J Pharmacol. 1994;113(3):994-1000.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

Rocepafant 132579-32-9 Others Platelet aggregation LAU 8080 LAU8080 BN 50730 LAU-8080 BN50730 BN-50730 inhibitor inhibit

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