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Propafenone hydrochloride

Catalog No. T6955 CAS 34183-22-7

Synonyms: Propafenone HCl, Arythmol, SA-79 (hydrochloride), Rytmonorm, Rythmol

Propafenone hydrochloride (Arythmol8) is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.

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Propafenone hydrochloride Chemical Structure

Propafenone hydrochloride, CAS 34183-22-7

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1 g	Inquiry	$ 48.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.67%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Propafenone hydrochloride (Arythmol8) is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.

In vitro

MK 3207 exhibits significantly higher affinity for both native and recombinant human CGRP receptor, as well as rhesus monkey CGRP receptor with Ki of 24 pM, ~24 pM and 22 pM, respectively, as compared to CGRP receptors from other species, including canine and rodent (Ki values of ~10 nM). Although has affinity for AMY1 (CTR/RAMP1) receptor with a Ki value of 0.75 nM, MK 3207 displays marked selectivity for human CGRP receptor versus related human AM1 (CLR/RAMP2) receptor, AM2 (CLR/RAMP3) receptor, AMY3 (CTR/RAMP3) receptor, and CTR with Ki values of 16.5 μM, 0.156 μM, 0.128 μM and 1.9 μM, respectively. MK 3207 potently inhibits human α-CGRP-induced cAMP production in HEK293 cells stably expressing human CLR/RAMP1 with an IC50 of 0.12 nM, and maintains similar potency in the presence of 50% human serum with an IC50 of 0.17 nM, indicating that the activity of MK 3207 would not be dramatically affected by plasma protein binding in vivo. MK 3207 exhibits approximately 65-fold more potent in the human serum-shifted in vitro functional assay than telcagepant with an IC50 of 10.9 nM. [1]

Synonyms	Propafenone HCl, Arythmol, SA-79 (hydrochloride), Rytmonorm, Rythmol
Molecular Weight	377.9
Formula	C21H27NO3·HCl
CAS No.	34183-22-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 64 mg/mL (169.4 mM)

References and Literature

1. http://en.wikipedia.org/wiki/Propafenone

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Ion Channel Inhibitor Library Clinical Compound Library Anti-Cancer Compound Library Bioactive Compound Library Orally Active Compound Library FDA-Approved & Pharmacopeia Drug Library

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Related compounds with same targets

Dibucaine hydrochloride NaV1.2/1.6 channel blocker-1 GS967 Quinidine hydrochloride monohydrate A-803467 VGSCs-IN-1 Phenytoin sodium μ-Conotoxin SxIIIC

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Propafenone hydrochloride 34183-22-7 Membrane transporter/Ion channel Sodium Channel Propafenone HCl Arythmol SA 79 Na+ channels SA-79 (hydrochloride) Na channels Inhibitor Rytmonorm SA-79 Propafenone SA79 inhibit Rythmol Propafenone Hydrochloride inhibitor

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