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Propafenone

Catalog No. T0866   CAS 54063-53-5
Synonyms: Rythmol, 普罗帕酮, Propafenonum

Propafenone is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. The electrophysiological effect of propafenone manifests itself in a reduction of upstroke velocity (Phase 0) of the monophasic action potential. In Purkinje fibers, and to a lesser extent myocardial fibers, propafenone reduces the fast inward current carried by sodium ions, which is responsible for the drugs antiarrhythmic actions. Diastolic excitability threshold is increased and effective refractory period prolonged. Propafenone reduces spontaneous automaticity and depresses triggered activity. At very high concentrations in vitro, propafenone can inhibit the slow inward current carried by calcium but this calcium antagonist effect probably does not contribute to antiarrhythmic efficacy.

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Propafenone, CAS 54063-53-5
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Propafenone is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. The electrophysiological effect of propafenone manifests itself in a reduction of upstroke velocity (Phase 0) of the monophasic action potential. In Purkinje fibers, and to a lesser extent myocardial fibers, propafenone reduces the fast inward current carried by sodium ions, which is responsible for the drugs antiarrhythmic actions. Diastolic excitability threshold is increased and effective refractory period prolonged. Propafenone reduces spontaneous automaticity and depresses triggered activity. At very high concentrations in vitro, propafenone can inhibit the slow inward current carried by calcium but this calcium antagonist effect probably does not contribute to antiarrhythmic efficacy.
Synonyms Rythmol, 普罗帕酮, Propafenonum
Molecular Weight 341.451
Formula C21H27NO3
CAS No. 54063-53-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Overington JP, et al. Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

Related compound libraries

This product is contained In the following compound libraries：
Anti-Cancer Compound Library Anti-Cardiovascular Disease Compound Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library Ion Channel Inhibitor Library Sodium Channel Blocker Library Immunology/Inflammation Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library FDA-Approved Drug Library

Related Products

Related compounds with same targets
Vindorosine Stauntosaponin A Isocudraniaxanthone B 4-Hydroxycinnamamide Wilfordine 11Beta-hydroxyprogesterone Benzocaine hydrochloride Sparteine sulfate

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Keywords

Propafenone 54063-53-5 离子通道 免疫与炎症 Sodium Channel Potassium Channel MRP Isus Propafenonum KcsA Drug repositioning mitochondria dysfunction SA-79 apoptosis esophageal Ito SA79 Rythmol Adrenergic Receptor inhibit ESCC antiarrhythmic agent mitochondrial dysfunction Na+ channels Inhibitor SA 79 Beta Receptor sodium-channel blocker Na channels inhibitor

 

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