pc12 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN1124	Neoeriocitrin		AChE
	Neoeriocitrin is a natural product isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is a potent acetylcholinesterase (AChE) inhibitor.		AChE
T28804	Slingshot inhibitor D3	JHN76359	Others
	Slingshot inhibitor D3 (JHN76359) is a potent inhibitor of the Protein Phosphatase Slingshot.		Others
T2S0731	Trilobatin	P-Phlorizin	Amylase
	Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopolysaccharide (LPS)-induced inflammatory respon...		Amylase
T2306	Brexpiprazole	OPC-34712	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
	Brexpiprazole (OPC-34712) is a partial agonist of human 5-hydroxytryptamine (5-HT) 5-HT1A and dopamine D2 receptors.		Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
T2S0843	Negletein	7-O-Methylbaicalein,Baicalein-7-methylether	IL Receptor , TNF , NOS , Interleukin
	1. Negletein (7-O-Methylbaicalein) has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces n...		IL Receptor , TNF , NOS , Interleukin
T12352	Oxidopamine hydrochloride	6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride	Mitophagy , Dopamine Receptor , Autophagy
	Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.		Mitophagy , Dopamine Receptor , Autophagy
T12352L	Oxidopamine hydrobromide	6-Hydroxydopamine hydrobromide,6-OHDA hydrobromide	Mitophagy , Dopamine Receptor , Autophagy
	Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.		Mitophagy , Dopamine Receptor , Autophagy
TN6924	Anhydrosafflor yellow B	(2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1,AHSYB	Others
	Anhydrosafflor yellow B ((2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,...		Others
T29109	VPC12249	VPC-12249,VPC 12249
	VPC12249, a lysophosphatidic acid receptor type 1 (LPA1) antagonist, plays a functional role in osteoclast differentiation and bone resorption activity.
T12384	PD 90780		Others
	PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 µM in PC12 cells and PC1...		Others
T2S0531	Pinoresinol dimethyl ether	(+)-Eudesmin	Others , PKC
	Pinoresinol dimethyl ether, a non-phenolic furan lignan isolated from the bark of Magnolia kobus, exhibits neuroactivity. It stimulates upstream MAPK, PKC, and PKA pathways, inducing neurite outgrowth in PC12 cells.		Others , PKC
TN6982	Diethyl phthalate	1,2-diethyl benzene-1,2-dicarboxylate	Apoptosis
	Diethyl phthalate (1,2-diethyl benzene-1,2-dicarboxylate) is a endocrine disrupter affecting the apoptotic system in PC12 cells. Diethyl phthalate is widely used in many plastics and personal care products.		Apoptosis
T5S2195	Sibiricose A5		Dehydrogenase
	Sibiricose A5 is a lactate dehydrogenase inhibitor, it displays antidepressant-like, and antioxidant actions. Sibiricose A5 can protect PC12 cells damage induced by P. tenuifolia.		Dehydrogenase
T15602	ITX3		Others , Rho
	ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM. ITX3 has anticancer effects, inhibits trion mediated GTP exchange on RhoG and Rac1, inhibits NGF-mediated neurite growth in P...		Others , Rho
T21919	UCF 101		Apoptosis
	UCF 101 is a specific inhibitor of HtrA2 and reduces apoptosis in PC12 cells.		Apoptosis
TN1911	Marein		transporter , Akt , HDAC , AMPK
	Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for ...		transporter , Akt , HDAC , AMPK
TN7108	Urolithin C		Apoptosis , Calcium Channel , Reactive Oxygen Species , IGF-1R , Endogenous Metabolite
	Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.
TN2082	Pinostrobin		Beta Amyloid , IL Receptor , Serine/threonin kinase , TNF
	Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppress...		Beta Amyloid , IL Receptor , Serine/threonin kinase , TNF
T3836	Eudesmin		MAPK , S6 Kinase
	Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.50 m...		MAPK , S6 Kinase
T2854	Phillyrin	Forsythin	P450 , Influenza Virus , AMPK
	Phillyrin (Forsythin) is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activ...		P450 , Influenza Virus , AMPK