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Phillyrin

Catalog No. T2854 CAS 487-41-2

Synonyms: Forsythin

Phillyrin (Forsythin) is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activation. Phillyrin(Forsythin) may be a new preventive agent of acute lung injury in the clinical setting, it potentially contributes to the suppression of the activation of MAPK and NF-κB pathways, it also has protective effects on H2O2-induced oxidative stress and apoptosis in PC12 cells.

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Phillyrin, CAS 487-41-2

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 64.00
25 mg	In stock	$ 129.00
50 mg	In stock	$ 188.00
100 mg	In stock	$ 283.00
500 mg	In stock	$ 688.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 99.71%

Purity: 98.76%

Biological Description

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Storage & Solubility Information

Description	Phillyrin (Forsythin) is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activation. Phillyrin(Forsythin) may be a new preventive agent of acute lung injury in the clinical setting, it potentially contributes to the suppression of the activation of MAPK and NF-κB pathways, it also has protective effects on H2O2-induced oxidative stress and apoptosis in PC12 cells.
In vitro	Phillyrin suppressed high glucose-induced lipid accumulation in HepG2 cells. Phillyrin strongly inhibited high glucose-induced fatty acid synthase (FAS) expression by modulating sterol regulatory element-binding protein-1c (SREBP-1c) activation. Moreover, use of the pharmacological AMP-activated protein kinase (AMPK) inhibitor revealed that AMPK is essential for suppressing SREBP-1c expression in Phillyrin-treated cells. Liver kinase B1 (LKB1) phosphorylation is required for the Phillyrin-enhanced activation of AMPK in HepG2 hepatocytes.
In vivo	Phillyrin has anti-obesity effect in nutritive obesity mice. Phillyrin could lower wet weight of fat (P < 0.01), fat index (P < 0.05 or P < 0.01), the diameter of fat cell and Lee's index (P < 0.05), decrease the jejunum microvillus area, lower the level of serum triglyceride and cholesterol.
Source	Natural Products > Oleaceae > Forsythia

Synonyms	Forsythin
Molecular Weight	534.55
Formula	C27H34O11
CAS No.	487-41-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 91 mg/mL(170.2 mM)

References and Literature

1. Do MT, et al. Phillyrin attenuates high glucose-induced lipid accumulation in human HepG2 hepatocytes through the activation of LKB1/AMP-activated protein kinase-dependent signalling. Food Chem. 2013 Jan 15;136(2):415-25. 2. Wei T, et al. Protective effects of phillyrin on H2O 2-induced oxidative stress and apoptosis in PC12 cells. Cell Mol Neurobiol. 2014 Nov;34(8):1165-73. 3. Zhong WT, et al. Phillyrin attenuates LPS-induced pulmonary inflammation via suppression of MAPK and NF-κB activation in acute lung injury mice. Fitoterapia. 2013 Oct;90:132-9.

Citations

1. Jiang H, Chen J, Li X, et al.Systematic identification of chemical components in Fufang Shuanghua oral liquid and screening of potential active components against SARS-CoV-2 protease.Journal of Pharmaceutical and Biomedical Analysis.2023, 223: 115118.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library FDA-Approved Kinase Inhibitor Library Traditional Chinese Medicine Monomer Library Anti-Cancer Drug Library NO PAINS Compound Library Epigenetics Compound Library Natural Product Library Anti-infective Natural Product Library

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Keywords

Phillyrin 487-41-2 Chromatin/Epigenetic Metabolism Microbiology/Virology PI3K/Akt/mTOR signaling P450 Influenza Virus AMPK Forsythin Cytochrome P450 CYPs Inhibitor inhibit inhibitor

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