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Oxidopamine hydrobromide

Name: Oxidopamine hydrobromide
Brand: TargetMol
SKU: T12352L
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12352LCas No. 636-00-0

Alias 6-OHDA hydrobromide, 6-Hydroxydopamine hydrobromide

Oxidopamine hydrobromide (6-OHDA hydrobromide) is a widely used neurotoxin and an antagonist of the neurotransmitter dopamine. It selectively destroys dopaminergic neurons, promotes COX-2 activation, induces PGE2 synthesis, and stimulates the secretion of the pro-inflammatory cytokine IL-1β. It is commonly used to establish animal models of Parkinson’s disease (PD).

Oxidopamine hydrobromide

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Purity: 99.88%

Catalog No. T12352LAlias 6-OHDA hydrobromide, 6-Hydroxydopamine hydrobromideCas No. 636-00-0

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$48	In Stock	In Stock
500 mg	$159	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.88%

Color:Yellow to Black

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Oxidopamine hydrobromide (6-OHDA hydrobromide) is a widely used neurotoxin and an antagonist of the neurotransmitter dopamine. It selectively destroys dopaminergic neurons, promotes COX-2 activation, induces PGE2 synthesis, and stimulates the secretion of the pro-inflammatory cytokine IL-1β. It is commonly used to establish animal models of Parkinson’s disease (PD).
Synonyms	6-OHDA hydrobromide, 6-Hydroxydopamine hydrobromide

Chemical Properties

Molecular Weight	250.09
Formula	C₈H₁₂BrNO₃
Cas No.	636-00-0
Smiles	Br.NCCc1cc(O)c(O)cc1O
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,store under nitrogen,The compound is unstable in solution. Please use soon | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (399.86 mM), Sonication is recommended. The compound is unstable in solution, please use soon.

DMSO: 125 mg/mL (499.82 mM), Sonication is recommended. The compound is unstable in solution, please use soon.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (15.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9986 mL	19.9928 mL	39.9856 mL	199.9280 mL
5 mM	0.7997 mL	3.9986 mL	7.9971 mL	39.9856 mL
10 mM	0.3999 mL	1.9993 mL	3.9986 mL	19.9928 mL
20 mM	0.1999 mL	0.9996 mL	1.9993 mL	9.9964 mL
50 mM	0.0800 mL	0.3999 mL	0.7997 mL	3.9986 mL
100 mM	0.0400 mL	0.1999 mL	0.3999 mL	1.9993 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc