Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for preventing/counteracting diabetic encephalopathy.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 55.00 | |
5 mg | In stock | $ 139.00 | |
10 mg | In stock | $ 198.00 | |
25 mg | In stock | $ 347.00 | |
50 mg | In stock | $ 516.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 162.00 |
Description | Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for preventing/counteracting diabetic encephalopathy. |
Targets&IC50 | HDAC:100 µM (IC50) |
In vitro | To clarify whether Marein, a major compound from the hypoglycemic plant Coreopsis tinctoria, prevents PC12 cell damage induced by MG, we cultured PC12 cells in the presence of MG and Marein. Marein attenuated MG-induced changes in the mitochondrial membrane potential (ΔΨm), mitochondrial permeability transition pores (mPTPs), intracellular Ca2+ levels, the production of reactive oxygen species (ROS), glutathione (GSH)/glutathione disulfide (GSSG) and adenosine triphosphate (ATP), and the increase in the percentage of apoptotic cells. Marein also increased glyoxalase I (Glo1) activity, phospho-AMPKα± (Thr172) and Bcl-2 expression and diminished the activation of Bax, caspase-3 and inhibitor of caspase-activated deoxyribonuclease (ICAD). Importantly, pretreatment of cells with Marein diminished the compound C-induced inactivation of p-AMPK. Molecular docking simulation showed that Marein interacted with the γ subunit of AMPK[1] |
Source |
Molecular Weight | 450.39 |
Formula | C21H22O11 |
CAS No. | 535-96-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (133.21 mM)
You can also refer to dose conversion for different animals. More
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Marein 535-96-6 Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair Metabolism PI3K/Akt/mTOR signaling Akt transporter AMPK HDAC GLUT1 Inhibitor inhibit antioxidative Histone deacetylases antihypertensive AMP-activated protein kinase IRS glycoside antihyperlipidemic antidiabetic GSK-3β FoxO1 neuroprotective CaMKK inhibitor