Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM. ITX3 has anticancer effects, inhibits trion mediated GTP exchange on RhoG and Rac1, inhibits NGF-mediated neurite growth in PC12 cells and REF52 fibroblast structure formation induced by trion.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 59.00 | |
10 mg | In stock | $ 109.00 | |
25 mg | In stock | $ 239.00 | |
50 mg | In stock | $ 465.00 | |
100 mg | In stock | $ 668.00 |
Description | ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM. ITX3 has anticancer effects, inhibits trion mediated GTP exchange on RhoG and Rac1, inhibits NGF-mediated neurite growth in PC12 cells and REF52 fibroblast structure formation induced by trion. |
Targets&IC50 | TrioN:76 μM |
In vitro | TrioN inhibitor In transfected mammalian cells, ITX3 blocked TrioN-mediated dorsal membrane ruffling and Rac1 activation while having no effect on GEF337-, Tiam1-, or Vav2-mediated RhoA or Rac1 activation. ITX3 specifically inhibited endogenous TrioN activity, as evidenced by its ability to inhibit neurite outgrowth in nerve growth factor (NGF)–stimulated PC12 cells or C2C12 differentiation into myotubes [1]. ITX3 repressed the Rac1 activity and dose-dependently up-regulated the E-cadherin protein level in the Tara-KD cells [2]. |
Molecular Weight | 371.45 |
Formula | C22H17N3OS |
CAS No. | 347323-96-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 1.8 mg/mL (4.8 mM), Sonication and heating to 80℃ are recommended.
You can also refer to dose conversion for different animals. More
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ITX3 347323-96-0 Cell Cycle/Checkpoint Others Rho ITX-3 ITX 3 inhibitor inhibit