Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Slingshot inhibitor D3 (JHN76359) is a potent inhibitor of the Protein Phosphatase Slingshot.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 48.00 | |
5 mg | In stock | $ 113.00 | |
10 mg | In stock | $ 197.00 | |
25 mg | In stock | $ 428.00 | |
50 mg | In stock | $ 639.00 | |
100 mg | In stock | $ 890.00 | |
500 mg | In stock | $ 1,830.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 125.00 |
Description | Slingshot inhibitor D3 (JHN76359) is a potent inhibitor of the Protein Phosphatase Slingshot. |
Targets&IC50 | SSH:3 Μm(Slingshot 1 ), SSH:3.9 μM (Ki; Slingshot 2) |
In vitro | Slingshot 1 had?IC50?value of 3 μM and Slingshot 2 had?Ki value of 3.9 μM.?Slingshot inhibitor D3 has similar inhibitory activitieswith Slingshot 1 and Slingshot 2. |
In vivo | Slingshot inhibitor D3 (5 μM; 45 minutes; PC12 cells;) significantly blocks NGF-induced dephosphorylation of cofilin at 15 and 30 minutes. Slingshot inhibitor D3 (5 μM; 45 minutes; PC12 cells) significantly decreases the NGF-induced cell migration, consistent with its inhibitory role in cofilin dephosphorylation. Slingshot inhibitor D3 (HEK293 cells) specifically blocks angiotensin II-induced cofilin dephosphorylation. Slingshot inhibitor D3 prevents cofilin dephosphroylation through inhibition of Slingshot. |
Synonyms | JHN76359 |
Molecular Weight | 461.55 |
Formula | C25H19NO4S2 |
CAS No. | 1715076-35-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 23.08 mg/mL (50 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
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Slingshot inhibitor D3 1715076-35-9 Others Inhibitor competitive PC12 reversible selective Slingshot inhibitor D-3 HEK293 JHN76359 JHN 76359 Slingshot inhibitor D 3 JHN-76359 potent inhibit inhibitor