Shopping Cart

Remove All

Your shopping cart is currently empty

PD 90780

Select Batch

Purity:98.75%

Resource Download

COA HPLC HNMR

PD 90780

Catalog No. T12384Cas No. 77422-99-2

PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 µM in PC12 cells and PC12nnr5 cells, respectively.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$51	In Stock
5 mg	$122	In Stock
10 mg	$197	In Stock
25 mg	$397	In Stock
50 mg	$589	In Stock
100 mg	$843	In Stock
1 mL x 10 mM (in DMSO)	$133	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "PD 90780"

Product Introduction

Bioactivity

Description	PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 µM in PC12 cells and PC12nnr5 cells, respectively.
In vitro	PD 90780 (0.1-100 μM; 2 h) affects 125I-BDNF binds to truncated p75NTR. PD 90780 (100 μM; 2 h) inhibits 125I-NGF cross-linking to p75NTR. PD 90780 (0-300 μM; 2 h) decreases TrkA phosphorylation resulting from NGF binding with a dose of 300 μM. PD 90780 (0.1-100 μM; 2 h) inhibits NGF-p75NTR interaction with IC50 values of 23.1 µM and 1.8 µM in PC12 cells and PC12nnr5 cells, respectively[1].

Chemical Properties

Molecular Weight	362.34
Formula	C19H14N4O4
Cas No.	77422-99-2

Storage & Solubility Information

Storage

|Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 28.8 mg/mL (79.5 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7598 mL	13.7992 mL	27.5984 mL	137.9919 mL
5 mM	0.5520 mL	2.7598 mL	5.5197 mL	27.5984 mL
10 mM	0.2760 mL	1.3799 mL	2.7598 mL	13.7992 mL
20 mM	0.1380 mL	0.6900 mL	1.3799 mL	6.8996 mL
50 mM	0.0552 mL	0.2760 mL	0.5520 mL	2.7598 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PD-90780PD 90780PD90780