Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 µM in PC12 cells and PC12nnr5 cells, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 51.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 197.00 | |
25 mg | In stock | $ 397.00 | |
50 mg | In stock | $ 589.00 | |
100 mg | In stock | $ 843.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 133.00 |
Description | PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 µM in PC12 cells and PC12nnr5 cells, respectively. |
Targets&IC50 | NGF (PC12 nnr5 cells):1.8 µM , NGF (PC12 cells):23.1 µM |
In vitro | PD 90780 (0.1-100 μM; 2 h) affects 125I-BDNF binds to truncated p75NTR. PD 90780 (100 μM; 2 h) inhibits 125I-NGF cross-linking to p75NTR. PD 90780 (0-300 μM; 2 h) decreases TrkA phosphorylation resulting from NGF binding with a dose of 300 μM. PD 90780 (0.1-100 μM; 2 h) inhibits NGF-p75NTR interaction with IC50 values of 23.1 µM and 1.8 µM in PC12 cells and PC12nnr5 cells, respectively[1]. |
Molecular Weight | 362.34 |
Formula | C19H14N4O4 |
CAS No. | 77422-99-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 28.8 mg/mL (79.5 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
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PD 90780 77422-99-2 Others PD-90780 PD90780 inhibitor inhibit