Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UCF 101 is a specific inhibitor of HtrA2 and reduces apoptosis in PC12 cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 48.00 | |
5 mg | In stock | $ 80.00 | |
10 mg | In stock | $ 139.00 | |
25 mg | In stock | $ 287.00 | |
50 mg | In stock | $ 455.00 | |
100 mg | In stock | $ 656.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 89.00 |
Description | UCF 101 is a specific inhibitor of HtrA2 and reduces apoptosis in PC12 cells. |
Targets&IC50 | His-Omi:9.5 μM (IC50) |
In vitro | PC12 cells treated with 60 μM 6-OHDA for 24 h had significantly decreased cell viability compared to that of controls. A low concentration (2.5 μM) of UCF 101 decreased the apoptosis rate of the PD cell model, but a high concentration (≥10 μM) increased the apoptosis rate, compared to that of controls. 6-OHDA upregulated the expression of HtrA2, α-syn, CHOP, Grp78 and active caspase-3 and reduced the levels of TH and XIAP[3]. |
In vivo | Administration of UCF 101 shortly before reperfusion reduced postischemic myocardial apoptosis in a dose-dependent fashion, with the maximal protective effect observed at a dose of 1.5 μmol/kg. This dose of UCF 101 (ie, 1.5 μmol/kg) was used in all subsequent experiments. To further establish that inhibition of Omi/HtrA2 protease activity led to significant inhibition of apoptosis, the effect of UCF 101 on DNA ladder formation, a hallmark of apoptotic cell death, was determined. 30 minutes of ischemia followed by 3 hours of reperfusion resulted in significant DNA fragmentation, which was significantly reduced by treatment with UCF 101 before reperfusion[2].UCF 101 reduced the level of ERS and apoptosis in vivo. The ratio of p-GSK3β (Tyr216 to Ser9) increased in PD rats[3]. |
Molecular Weight | 495.51 |
Formula | C27H17N3O5S |
CAS No. | 313649-08-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12.5 mg/mL (25.23 mM)
You can also refer to dose conversion for different animals. More
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UCF 101 313649-08-0 Apoptosis Omi red Ucf-101 UCF-101 inhibit pro-apoptotic 543 HtrA2 MI/R Inhibitor cardioprotective His-Omi neuroprotective protease UCF101 Ucf101 fluorescence inhibitor