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UCF 101

Catalog No. T21919   CAS 313649-08-0

UCF 101 is a specific inhibitor of HtrA2 and reduces apoptosis in PC12 cells.

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UCF 101 Chemical Structure
UCF 101, CAS 313649-08-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 34.00
2 mg In stock $ 48.00
5 mg In stock $ 80.00
10 mg In stock $ 139.00
25 mg In stock $ 287.00
50 mg In stock $ 455.00
100 mg In stock $ 656.00
1 mL * 10 mM (in DMSO) In stock $ 89.00
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Purity: 98.08%
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Biological Description
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Storage & Solubility Information
Description UCF 101 is a specific inhibitor of HtrA2 and reduces apoptosis in PC12 cells.
Targets&IC50 His-Omi:9.5 μM (IC50)
In vitro PC12 cells treated with 60 μM 6-OHDA for 24 h had significantly decreased cell viability compared to that of controls. A low concentration (2.5 μM) of UCF 101 decreased the apoptosis rate of the PD cell model, but a high concentration (≥10 μM) increased the apoptosis rate, compared to that of controls. 6-OHDA upregulated the expression of HtrA2, α-syn, CHOP, Grp78 and active caspase-3 and reduced the levels of TH and XIAP[3].
In vivo Administration of UCF 101 shortly before reperfusion reduced postischemic myocardial apoptosis in a dose-dependent fashion, with the maximal protective effect observed at a dose of 1.5 μmol/kg. This dose of UCF 101 (ie, 1.5 μmol/kg) was used in all subsequent experiments. To further establish that inhibition of Omi/HtrA2 protease activity led to significant inhibition of apoptosis, the effect of UCF 101 on DNA ladder formation, a hallmark of apoptotic cell death, was determined. 30 minutes of ischemia followed by 3 hours of reperfusion resulted in significant DNA fragmentation, which was significantly reduced by treatment with UCF 101 before reperfusion[2].UCF 101 reduced the level of ERS and apoptosis in vivo. The ratio of p-GSK3β (Tyr216 to Ser9) increased in PD rats[3].
Molecular Weight 495.51
Formula C27H17N3O5S
CAS No. 313649-08-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 12.5 mg/mL (25.23 mM)

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library Bioactive Compound Library Mitochondria-Targeted Compound Library Bioactive Compounds Library Max

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Keywords

UCF 101 313649-08-0 Apoptosis Omi red Ucf-101 UCF-101 inhibit pro-apoptotic 543 HtrA2 MI/R Inhibitor cardioprotective His-Omi neuroprotective protease UCF101 Ucf101 fluorescence inhibitor

 

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