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Pinostrobin

Catalog No. TN2082 CAS 480-37-5

Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα2(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppressing the mitochondrial pathway of cellular apoptosis.

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Pinostrobin, CAS 480-37-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 208.00
5 mg	In stock	$ 445.00
10 mg	In stock	$ 659.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,380.00
1 mL * 10 mM (in DMSO)	In stock	$ 418.00

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Purity: 99.35%

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Description	Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα2(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppressing the mitochondrial pathway of cellular apoptosis.
In vitro	Pinostrobin was isolated from the dichloromethane extract of Renealmia alpinia leaves. The protective properties of the extract and of Pinostrobin against the indirect hemolytic, coagulant and proteolytic effects of Bothrops asper venom were evaluated in vitro, and the anti-hemorrhagic and anti-inflammatory activity were evaluated in vivo. Renealmia alpinia extract significantly inhibited the proteolytic activity and indirect hemolytic activity of Bothrops asper venom at a venom:extract ratio of 1:20. Moreover, the present data demonstrate that Pinostrobin may mitigate some venom-induced local tissue damage due to hemorrhagic effects, and the compound is also responsible for the analgesic and anti-inflammatory activity of the extract from Renealmia alpinia. This is the first report to describe Pinostrobin in the species Renealmia alpinia and its properties in vitro against Bothrops asper venom[1]
Source	Natural Products > Fabaceae > Cajanus

Molecular Weight	270.28
Formula	C16H14O4
CAS No.	480-37-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (221.98 mM)

References and Literature

1. Inhibition of the toxic effects of Bothrops asper venom by pinostrobin, a flavanone isolated from Renealmia alpinia (Rottb.) MAAS.J Ethnopharmacol. 2014 Sep 29;155(3):1609-15.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Kinase Inhibitor Library Antiparasitic Natural Product Library Anti-Cancer Active Compound Library Inhibitor Library NF-κB Signaling Compound Library Anti-Tumor Natural Product Library Anti-Alzheimer's Disease Compound Library Natural Product Library for HTS Flavonoid Natural Product Library

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Keywords

Pinostrobin 480-37-5 Apoptosis Cell Cycle/Checkpoint Immunology/Inflammation Metabolism Neuroscience Serine/threonin kinase TNF Beta Amyloid IL Receptor Threonine proteases inhibit Serine proteases Inhibitor foxO3a cholesterol anti-cancer,neuroprotective Ser/Thr Protease Serine endopeptidases anti-inflammatory PCSK9 anti-oxidant inhibitor

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