Search Result

Search Results for " mln "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T28072L	MLN-3897 TFA	MLN-3897 TFA(1010731-97-1 Free base)	CCR
	MLN-3897 TFA is a potent CCR1 antagonist that inhibits the binding of 125I-MIP-1α to THP-1 cell membranes.		CCR
T16116	MLN-4760		RAAS
	MLN-4760 is an angiotensin-converting (ACE2) inhibitor(human ACE2;IC50=0.44 nM). It also has excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypept...		RAAS
T71380	MLN-0415
	MLN-0415 is an IKK2 inhibitor which decreases NF-κB activation and down-regulates the expression of a number of inflammatory proteins.
T35187	XR 5944	XR-5944,MLN-944,MLN944,XR5944,MLN 944
	XR 5944 is an effective DNA binder that stabilizes topoisomerase-dependent cleavage and has shown superior efficacy in a variety of mouse and human tumor models.
T77118	Plozalizumab	MLN-1202	CCR
	Plozalizumab (MLN-1202) is a humanized selective and potent anti-CCR2 antibody.Plozalizumab has antitumor activity.Plozalizumab is used in the study of malignant melanoma.		CCR
T68427	MLN-3897 citrate
	MLN-3897 citrate is a C-C Motif Chemokine Receptor 1 (CCR1) antagonist potentially for the treatment of multiple sclerosis and rheumatoid arthritis.
T28072	MLN-3897	AVE9897,AVE 9897,CCR1 antagonist 10,AVE-9897	CCR
	MLN-3897 (CCR1 antagonist 10) is an orally active antagonist of CCR1 with a Ki of 2.3 nM for 125I-MIP-1α binding to THP-1 cell membranes. MLN-3897 inhibits Akt signaling and MM cell survival and proliferation.		CCR
T2241	Alisertib	MLN 8237	Apoptosis , Aurora Kinase , Autophagy
	Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.		Apoptosis , Aurora Kinase , Autophagy
T72913	(R)-MLN-4760
	(R)-MLN-4760, the R-enantiomer of MLN-4760, functions as an ACE2 inhibitor and exhibits a half maximal inhibitory concentration (IC50) of 8.4 μM, identifying it as the less active isomer.
T6315	MLN8054		Casein Kinase , PKA , Src , Aurora Kinase
	MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.		Casein Kinase , PKA , Src , Aurora Kinase
T2016	MLN9708	Ixazomib Citrate	Proteasome
	MLN2238 suppresses the chymotrypsin-like proteolytic (β5) site of the 20S proteasome(Ki50=0.93 nM, IC50=3.4 nM/). The biologically active form of MLN9708 (Ixazomib Citrate) is MLN2238 in aqueous solutions or plasma.		Proteasome
T2704	MLN0905	PLK1 Inhibitor	PLK
	MLN0905 (PLK1 Inhibitor) is an effective PLK1 inhibitor(IC50=2 nM).		PLK
T6332	Pevonedistat	MLN4924	E1/E2/E3 Enzyme , NEDD8
	Pevonedistat (MLN4924) is a potent and selective NEDD8 activating enzyme (NAE) inhibitor (IC50=4.7 nM). Pevonedistat can be used for the treatment of myelodysplastic syndromes (MDS) and also has antitumor activity.		E1/E2/E3 Enzyme , NEDD8
T2122	Ixazomib	MLN2238	Proteasome , Caspase , Autophagy
	Ixazomib (MLN2238) , a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome (IC50/Ki: 3.4/0.93 nM, in cell-free assays), also i...		Proteasome , Caspase , Autophagy
T8397	Ixazomib citrate	MLN9708	Proteasome , Autophagy
	Ixazomib citrate (MLN9708) is a prodrug of Ixazomib (MMLN-2238). MLN9708 is an orally bioavailable second generation proteasome inhibitor (IC50 of 3.4 nM ) with potential antineoplastic activity.		Proteasome , Autophagy
T26339	XR-11576	MLN-576,MLN 576,MLN576,XR 11576
	XR-11576 is a DNA topoisomerase I and II inhibitor for the treatment of solid tumors.
T80554	Myoregulin	MLN peptide	Calcium Channel
	Myoregulin (MLN peptide), a regulin family member, modulates muscle performance through intracellular calcium handling. It directly interacts with the sarcoplasmic reticulum Ca^2+-ATPase (SERCA), impeding Ca^2+ uptake in...		Calcium Channel
T80555	Myoregulin TFA	MLN peptide TFA	Calcium Channel
	Myoregulin (MLN peptide) TFA, belonging to the regulin family, is a regulator of muscle performance through modulation of intracellular calcium dynamics. It specifically interacts with sarcoplasmic reticulum Ca2+-ATPase ...		Calcium Channel
T38428	Alisertib sodium	MLN 8237 sodium
	Alisertib sodium (MLN 8237) is a potent and specific inhibitor (IC50 = 1.2 nM) of Aurora A kinase, an enzyme involved in cell division. By binding to Aurora A kinase, Alisertib sodium disrupts the formation of the mitoti...
T6895	TAK-580	MLN2480,BIIB-024	Raf
	TAK-580 (MLN2480) is an oral, selective pan-Raf kinase inhibitor in Clinicalal trials.		Raf
T3153	Serabelisib	TAK-117,INK1117,MLN1117	PI3K , mTOR
	Serabelisib (INK1117) is a p110α/β/γ/δ inhibitor (IC50: 15/4.5/1.9/13.39 μM).		PI3K , mTOR
T1838	Sapanisertib	TAK-228,MLN0128,INK 128	PI3K , mTOR , Autophagy
	Sapanisertib (INK 128) is an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity.		PI3K , mTOR , Autophagy
T16974	TAK-243	MLN7243	Apoptosis , E1/E2/E3 Enzyme , NF-κB
	TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM). TAK-243 blocks ubiquitin binding and disrupts mono-ubiquitin signaling as well as overall protein ubiquitination. TAK-243 exh...		Apoptosis , E1/E2/E3 Enzyme , NF-κB
TQ0306	MLN120B		IκB/IKK
	MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).		IκB/IKK
T1667	Tandutinib	MLN518,CT53518,NSC726292	Apoptosis , FLT , CSF-1R , PDGFR , Src , c-Kit
	Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versu...		Apoptosis , FLT , CSF-1R , PDGFR , Src , c-Kit
T68489	MLN8054 sodium
	MLN8054 sodium is an Aurora A inhibitor.
T69982	VPC-16606
	VPC-16606 is a potent and selective inhibitor of ERα-dependent cell growth and gene expression. VPC-16606 prevents the interaction between ERα-LBD and SRC-3 fusion proteins in a dose-dependent manner.
T71378	Exp9270
	Exp9270 is an Angiotensin II receptor antagonist.
T16117	Pevonedistat hydrochloride	MLN4924 hydrochloride	Others
	Pevonedistat hydrochloride is an effective and selective inhibitor of NEDD8-activating enzyme (IC50: 4.7 nM).		Others
T69889	JBP485
	JBP485 is an inhibitor of renal transporters OAT1 and OAT3. JBP485 is an antihepatitis agent as a substrate for intestinal PEPT1.
T23418	Tandutinib (MLN518) HCl		Others
	Tandutinib is an effective antagonist for FLT3, platelet-derived growth factor receptor (PDGFR), and c-Kit. Tandutinib potently inhibited the activity of FLT3, PDGFR, and c-Kit (IC50: ~200 nM).		Others
T39199	ML 120B dihydrochloride	ML120B dihydrochloride
	MLN120B dihydrochloride (ML120B dihydrochloride) is a highly potent, orally active inhibitor of IKKβ. It competitively binds to ATP and exhibits an impressive IC50 value of 60 nM. This compound effectively suppresses the...
T80770	Wt hMLN TFA
	WT hMLN (TFA) is a microprotein that functions as an inhibitor of the SR Ca2+ pump (SERCA), playing a crucial role in the regulation of calcium homeostasis in skeletal muscle [1].
T80556	Wt hMLN		Calcium Channel
	Wild-type human myoregulin (wt hMLN) is a microprotein that inhibits the sarcoplasmic reticulum Ca²⁺ pump (SERCA), playing a crucial role in the regulation of calcium homeostasis in skeletal muscle [1].		Calcium Channel
T62660	MLN3126
	MLN3126 is an orally active, potent CCR9 antagonist. MLN3126 inhibits CCL25-induced calcium mobilization and chemotaxis in mouse primary thymocytes with an IC50 value of 6.3 nM for calcium influx inhibition.

Compounds

MLN-3897 TFA

T28072L

Synonym: MLN-3897 TFA(1010731-97-1 Free base)

Synonym: XR-5944,MLN-944,MLN944,XR5944,MLN 944

Synonym: AVE9897,AVE 9897,CCR1 antagonist 10,AVE-9897

Target: Apoptosis, Aurora Kinase, Autophagy

Target: Casein Kinase, PKA, Src, Aurora Kinase

MLN9708

T2016

Synonym: Ixazomib Citrate

Target: Proteasome

MLN0905

T2704

Synonym: PLK1 Inhibitor

Target: E1/E2/E3 Enzyme, NEDD8

Ixazomib

T2122

Synonym: MLN2238

Target: Proteasome, Caspase, Autophagy

Ixazomib citrate

T8397

Synonym: MLN9708

Target: Proteasome, Autophagy

XR-11576

T26339

Synonym: MLN-576,MLN 576,MLN576,XR 11576

Target:

Myoregulin

T80554

Synonym: MLN peptide

Target: Calcium Channel

Myoregulin TFA

T80555

Synonym: MLN peptide TFA

Target: Calcium Channel

Alisertib sodium

T38428

Synonym: MLN 8237 sodium

Target:

TAK-580

T6895

Synonym: MLN2480,BIIB-024

Target: Raf

Serabelisib

T3153

Synonym: TAK-117,INK1117,MLN1117

Target: PI3K, mTOR

Sapanisertib

T1838

Synonym: TAK-228,MLN0128,INK 128

Target: PI3K, mTOR, Autophagy

TAK-243

T16974

Synonym: MLN7243

Target: Apoptosis, E1/E2/E3 Enzyme, NF-κB

Synonym: MLN518,CT53518,NSC726292

Target: Apoptosis, FLT, CSF-1R, PDGFR, Src, c-Kit

Pevonedistat hydrochloride

T16117

Synonym: MLN4924 hydrochloride

Tandutinib (MLN518) HCl

T23418

Synonym:

Target: Others

ML 120B dihydrochloride

T39199

Synonym: ML120B dihydrochloride

Target: Calcium Channel

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-04207	Motilin Protein, Human, Recombinant (His)	Human	HEK293 Cells
	MLN (Motilin) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal c...
TMPY-04698	HER2/ERBB2 Protein, Human, Recombinant (aa 489-630, His)	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (aa 489-630, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.1 kDa and the accession number is P04626-1.
TMPY-05239	HER2/ERBB2 Protein, Human, Recombinant , Biotinylated	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant , Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 70 kDa and the accession number is P04626-1.
TMPY-04684	HER2/ERBB2 Protein, Human, Recombinant (aa 1-195, His)	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (aa 1-195, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.9 kDa and the accession number is P04626-1.
TMPY-00167	HER2/ERBB2 Protein, Human, Recombinant	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 70 kDa and the accession number is P04626-1.
TMPY-01137	HER2/ERBB2 Protein, Human, Recombinant (aa 1-652, His)	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (aa 1-652, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71 kDa and the accession number is P04626-1.
TMPK-00428	HER2/ErbB2 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for t...
TMPK-00429	HER2/ERBB2 Domain 4 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	HER2/ERBB2 Domain 4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 18.5 kDa and the accession number is P04626-1.
TMPK-00430	HER2/ERBB2 Domain 4 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	HER2/ERBB2 Domain 4 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 18.5 kDa and the accession number is P04626-1.
TMPJ-00778	HER2/ERBB2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 90-120 KDa and the accession number is P04626.
TMPY-05754	HER2/ERBB2 Protein, Human, Recombinant (aa 489-630, His), Amine-Labeled Biotinylated	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (aa 489-630, His), Amine-Labeled Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.1 kDa and the accession number is AAA75493.1.
TMPY-05315	HER2/ERBB2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 72.6 kDa and the accession number is P04626-1.
TMPY-06612	HER2/ERBB2 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 95.75 kDa and the accession number is NP_004439.2.
TMPY-00745	HER2/ERBB2 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.1 kDa and the accession number is P04626-1.
TMPY-04538	HER2/ERBB2 Protein, Human, Recombinant (aa 676-1255, His & GST)	Human	Baculovirus Insect Cells
	HER2/ERBB2 Protein, Human, Recombinant (aa 676-1255, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 92 kDa and the accession number is P04626-1.
TMPY-05368	HER2/ERBB2 Protein, Human, Recombinant (hFc), Biotinylated	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.1 kDa and the accession number is P04626-1.
TMPY-04955	HER2/ERBB2 Protein, Human, Recombinant (His), Amine-Labeled Biotinylated	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (His), Amine-Labeled Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71 kDa and the accession number is P04626-1.
TMPY-01331	S100A11 Protein, Human, Recombinant	Human	E. coli
	S100A11 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 24 and 12 kDa and the accession number is P31949.
TMPJ-00777	HER2/ERBB2 Protein, Human, Recombinant (aa 23-652, hFc)	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (aa 23-652, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 120-145 KDa and the accession number is P04626.
TMPJ-00776	HER2/ERBB2 Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Fc-Avi tag. The predicted molecular weight is 120-140 KDa and the accession number is P04626.