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MLN-3897

Catalog No. T28072   CAS 1010731-97-1
Synonyms: AVE9897, AVE 9897, CCR1 antagonist 10, AVE-9897

MLN-3897 (CCR1 antagonist 10) is an orally active antagonist of CCR1 with a Ki of 2.3 nM for 125I-MIP-1α binding to THP-1 cell membranes. MLN-3897 inhibits Akt signaling and MM cell survival and proliferation.

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MLN-3897 Chemical Structure
MLN-3897, CAS 1010731-97-1
Pack Size Availability Price/USD Quantity
25 mg 8-10 weeks $ 1,330.00
50 mg 8-10 weeks $ 1,728.00
100 mg 8-10 weeks $ 2,595.00
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage & Solubility Information
Description MLN-3897 (CCR1 antagonist 10) is an orally active antagonist of CCR1 with a Ki of 2.3 nM for 125I-MIP-1α binding to THP-1 cell membranes. MLN-3897 inhibits Akt signaling and MM cell survival and proliferation.
Synonyms AVE9897, AVE 9897, CCR1 antagonist 10, AVE-9897
Molecular Weight 519.03
Formula C30H31ClN2O4
CAS No. 1010731-97-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Pusalkar S, et al. Metabolism, Excretion and Pharmacokinetics of MLN3897, a CCR1 Antagonist, in Humans. Drug Metab Lett. 2016;10(1):22-37. 2. Vergunst CE, et al. MLN3897 plus methotrexate in patients with rheumatoid arthritis: safety, efficacy, pharmacokinetics, and pharmacodynamics of an oral CCR1 antagonist in a phase IIa, double-blind, placebo-controlled, randomized, proof-of-concept study. Arthritis Rheum. 2009 Dec;60(12):3572-81. 3. Lu C, et al. Quantitative prediction and clinical observation of a CYP3A inhibitor-based drug-drug interactions with MLN3897, a potent C-C chemokine receptor-1 antagonist. J Pharmacol Exp Ther. 2010 Feb;332(2):562-8. 4. Vallet S, et al. MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts. Blood. 2007 Nov 15;110(10):3744-52. 5. Kenneth G. Carson, et al. Ccr1 antagonists for the treatment of i.a. demyelinating inflammatory disease. WO2004043965A1.

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Keywords

MLN-3897 1010731-97-1 Immunology/Inflammation Microbiology/Virology CCR AVE9897 MLN3897 AVE 9897 CCR1 antagonist 10 AVE-9897 MLN 3897 inhibitor inhibit

 

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