Cell Cycle/Checkpoint PLK MLN0905


Catalog No. T2704   CAS 1228960-69-7
Synonyms: PLK1 Inhibitor

MLN0905 is an effective PLK1 inhibitor(IC50=2 nM).

MLN0905, CAS 1228960-69-7
Pack Size Availability Price/USD Quantity
1 mg In stock 80.00
2 mg In stock 130.00
5 mg In stock 170.00
10 mg In stock 292.00
25 mg In stock 560.00
50 mg Inquiry 957.00
1 mL * 10 mM (in DMSO) In stock 170.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description MLN0905 is an effective PLK1 inhibitor(IC50=2 nM).
Targets&IC50 PLK1 : ic50 2nM,  
Kinase Assay PLK1 Flash Plate Assay: The human PLK1 enzymatic reaction totaling 30μL contained 50 mM Tris-HCl (pH 8.0), 10 mM MgCl2, 0.02% BSA, 10% glycerol, 1 mM DTT, 100 mM NaCl, 3.3% DMSO, 8 μM ATP, 0.2μCi [γ- 33 P]-ATP, 4μM peptide substrate (Biotin-AHX-LDETGHLDSSGLQEVHLA-CONH2), and 10 nM recombinant human PLK1[2–369]T210D. The enzymatic reaction mixture, with or without PLK inhibitors, is incubated for 2.5 h at 30℃before termination with 20μL of 150 mM EDTA. Then 25μL of the stopped enzyme reaction mixture is transferred to a 384-well streptavidin coated Image FlashPlate and incubated at room temperature for 3 h. The Image Flash Plate wells are washed three times with 0.02% Tween-20 and then read on the Perkin-Elmer Viewlux.
Synonyms PLK1 Inhibitor
Purity 99.38%
Molecular Weight 486.56
Formula C24H25F3N6S
CAS No. 1228960-69-7


0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 90 mg/mL (185 mM)

Ethanol: <1 mg/mL

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )


References and Literature
1. Duffey MO, et al. J Med Chem, 2012, 55(1), 197-208. 2. Shi JQ, et al. Mol Cancer Ther, 2012, 11(9), 2045-2053.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Kinase Inhibitor Library Fluorochemical Library Cell cycle related Compound Library

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