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Cell Cycle/Checkpoint PLK MLN0905

MLN0905

Catalog No. T2704   CAS 1228960-69-7
Synonyms: PLK1 Inhibitor

MLN0905 is an effective PLK1 inhibitor(IC50=2 nM).

MLN0905, CAS 1228960-69-7
Pack Size Availability Price/USD Quantity
1 mg In stock 80.00
2 mg In stock 130.00
5 mg In stock 170.00
10 mg In stock 292.00
25 mg In stock 560.00
50 mg Inquiry 957.00
1 mL * 10 mM (in DMSO) In stock 170.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description MLN0905 is an effective PLK1 inhibitor(IC50=2 nM).
Targets&IC50 PLK1 : ic50 2nM,  
Kinase Assay PLK1 Flash Plate Assay: The human PLK1 enzymatic reaction totaling 30μL contained 50 mM Tris-HCl (pH 8.0), 10 mM MgCl2, 0.02% BSA, 10% glycerol, 1 mM DTT, 100 mM NaCl, 3.3% DMSO, 8 μM ATP, 0.2μCi [γ- 33 P]-ATP, 4μM peptide substrate (Biotin-AHX-LDETGHLDSSGLQEVHLA-CONH2), and 10 nM recombinant human PLK1[2–369]T210D. The enzymatic reaction mixture, with or without PLK inhibitors, is incubated for 2.5 h at 30℃before termination with 20μL of 150 mM EDTA. Then 25μL of the stopped enzyme reaction mixture is transferred to a 384-well streptavidin coated Image FlashPlate and incubated at room temperature for 3 h. The Image Flash Plate wells are washed three times with 0.02% Tween-20 and then read on the Perkin-Elmer Viewlux.
Synonyms PLK1 Inhibitor
Purity 99.38%
Molecular Weight 486.56
Formula C24H25F3N6S
CAS No. 1228960-69-7

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 90 mg/mL (185 mM)

Ethanol: <1 mg/mL

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Duffey MO, et al. J Med Chem, 2012, 55(1), 197-208. 2. Shi JQ, et al. Mol Cancer Ther, 2012, 11(9), 2045-2053.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Kinase Inhibitor Library Fluorochemical Library Cell cycle related Compound Library

Related Products

Related compounds with same targets
ON-01910 Rigosertib TC-S 7005 Poloxime Poloxin 7-O-Prenylscopoletin ON-01910 HMN176

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.