keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ixazomib citrate (MLN9708) is a prodrug of Ixazomib (MMLN-2238). MLN9708 is an orally bioavailable second generation proteasome inhibitor (IC50 of 3.4 nM ) with potential antineoplastic activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 43.00 | |
10 mg | In stock | $ 61.00 | |
25 mg | In stock | $ 93.00 | |
50 mg | In stock | $ 126.00 | |
100 mg | In stock | $ 207.00 | |
500 mg | In stock | $ 515.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 48.00 |
Description | Ixazomib citrate (MLN9708) is a prodrug of Ixazomib (MMLN-2238). MLN9708 is an orally bioavailable second generation proteasome inhibitor (IC50 of 3.4 nM ) with potential antineoplastic activity. |
Targets&IC50 | 20S proteasome β5:3.4 nM , 20S proteasome β2:3500 nM, 20S proteasome β1:31 nM |
In vitro | Treatment of MM cells with MLN2238 predominantly inhibits chymotrypsin-like activity of the proteasome and induces accumulation of ubiquitinated proteins. MLN2238 inhibits growth and induces apoptosis in MM cells resistant to conventional and bortezomib therapies without affecting the viability of normal cells[1]. |
In vivo | In animal tumor model studies, MLN2238 is well tolerated and inhibits tumor growth with significantly reduced tumor recurrence. A head-to-head analysis of MLN2238 versus bortezomib showed a significantly longer survival time in mice treated with MLN2238 than mice receiving bortezomib[1]. |
Synonyms | MLN9708 |
Molecular Weight | 517.12 |
Formula | C20H23BCl2N2O9 |
CAS No. | 1239908-20-3 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (193.38 mM)
You can also refer to dose conversion for different animals. More
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Ixazomib citrate 1239908-20-3 Autophagy Proteases/Proteasome Ubiquitination Proteasome Ixazomib Inhibitor MLN 9708 Ixazomib Citrate MLN-9708 inhibit MLN9708 inhibitor