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Ixazomib citrate

Catalog No. T8397   CAS 1239908-20-3
Synonyms: MLN9708

Ixazomib citrate (MLN9708) is a prodrug of Ixazomib (MMLN-2238). MLN9708 is an orally bioavailable second generation proteasome inhibitor (IC50 of 3.4 nM ) with potential antineoplastic activity.

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Ixazomib citrate Chemical Structure
Ixazomib citrate, CAS 1239908-20-3
Pack Size Availability Price/USD Quantity
5 mg In stock $ 43.00
10 mg In stock $ 61.00
25 mg In stock $ 93.00
50 mg In stock $ 126.00
100 mg In stock $ 207.00
500 mg In stock $ 515.00
1 mL * 10 mM (in DMSO) In stock $ 48.00
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Purity: 100%
Purity: 98.37%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ixazomib citrate (MLN9708) is a prodrug of Ixazomib (MMLN-2238). MLN9708 is an orally bioavailable second generation proteasome inhibitor (IC50 of 3.4 nM ) with potential antineoplastic activity.
Targets&IC50 20S proteasome β5:3.4 nM , 20S proteasome β2:3500 nM, 20S proteasome β1:31 nM
In vitro Treatment of MM cells with MLN2238 predominantly inhibits chymotrypsin-like activity of the proteasome and induces accumulation of ubiquitinated proteins. MLN2238 inhibits growth and induces apoptosis in MM cells resistant to conventional and bortezomib therapies without affecting the viability of normal cells[1].
In vivo In animal tumor model studies, MLN2238 is well tolerated and inhibits tumor growth with significantly reduced tumor recurrence. A head-to-head analysis of MLN2238 versus bortezomib showed a significantly longer survival time in mice treated with MLN2238 than mice receiving bortezomib[1].
Synonyms MLN9708
Molecular Weight 517.12
Formula C20H23BCl2N2O9
CAS No. 1239908-20-3

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (193.38 mM)

TargetMolReferences and Literature

1. Chauhan D, et al. In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells. Clin Cancer Res. 2011 Aug 15;17(16):5311-21.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Targeted Therapy Drug Library HIF-1 Signaling Pathway Compound Library Autophagy Compound Library Protease Inhibitor Library NO PAINS Compound Library Pediatric Drug Library

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Keywords

Ixazomib citrate 1239908-20-3 Autophagy Proteases/Proteasome Ubiquitination Proteasome Ixazomib Inhibitor MLN 9708 Ixazomib Citrate MLN-9708 inhibit MLN9708 inhibitor

 

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