Search Result

Search Results for " mcp "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T24437	MCP110	MCP-110,MCP 110	Raf , Ras
	MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.		Raf , Ras
T8316	1V209	TLR7 agonist T7	TLR
	1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.		TLR
T13114	CCR2 antagonist 4	Teijin compound 1	CCR
	CCR2 antagonist 4 (Teijin compound 1) is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nM).		CCR
T20701	MCPA	NSC-2351,Krezone,NSC2351,NSC 2351,U 46 M-Fluid,Raphone	Others
	MCPA（Krezone） is a highly effective phenoxy herbicide. Use of MCPA would have impacts on nearby water and soil resources.		Others
T3479	(RS)-MCPG	alpha-MCPG,(±)-MCPG	GluR
	(RS)-MCPG ((±)-MCPG) is a non-selective group I/II metabotropic glutamate receptor antagonist.		GluR
T20948	MCPA-thioethyl	HOK 7501,HOK7501,HOK-7501
	MCPA-thioethyl is a biochemical.
T13452	(S)-MCPG	(+)-MCPG	Others
	(S)-MCPG is the active isomer of (RS)-MCPG, non-selective group I/group II metabotropic glutamate receptor antagonist.		Others
T23270	(RS)-MCPG disodium salt		Others
	group I/group II metabotropic glutamate receptor antagonist		Others
T27987	mCPBG	m-Chlorophenylbiguanide
	mCPBG is a potent high affinity agonist of 5-HT3 receptor.
T61364	LmCPB-IN-1
	LmCPB-IN-1 (compound 35) is a highly effective and reversible covalent inhibitor of Leishmania mexicana cysteine protease B (LmCPB). It exhibits a strong binding affinity with a pK i value of 9.7 [1].
T81054	T-1-MCPAB		VEGFR
	T-1-MCPAB, a VEGFR-2 inhibitor with an IC50 of 0.135 µM, effectively suppresses MCF7 cell migration and has applications in cancer research [1].		VEGFR
T83130	AMCPy
	AMCPy, a potent electron paramagnetic resonance (EPR) brain imaging agent, boasts excellent lipophilicity, facilitating its penetration through the blood-brain barrier (BBB) [1].
T33228	MCPA-potassium
	MCPA-potassium is a bioactive chemical.
T33227	MCPA-butyl	Yamaclean M
	MCPA-butyl is a biochemical.
T11648	INCB 3284		Others
	INCB 3284, a potent and selective human CCR2 antagonist with an oral bioavailability, is utilized in the study of acute liver failure. It effectively inhibits the binding of monocyte chemoattractant protein-1 (MCP-1) to ...		Others
T4674	SB297006	SB 297006	CCR
	SB297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. It is at least 250-fold selective for CCR3 over a panel of ...		CCR
T11079	NMI 8739	n-docosahexaenoyl dopamine,Dha-DA conjugate	Dopamine Receptor
	NMI 8739 (n-docosahexaenoyl dopamine) is an agonist of D2 autoreceptor. NMI 8739 reduces NO production and elicits concentration-dependent suppression of CCL-20, MCP-1 and IL-6 release.		Dopamine Receptor
T16091	MK-0812 Succinate		Others , CCR
	MK-0812 Succinate is an effective and selective CCR2 antagonist. It also has a high affinity at CCR2.		Others , CCR
T19230	CCR2 antagonist 4 hydrochloride	Teijin compound 1 hydrochloride	Others
	CCR2 antagonist 4 hydrochloride is a specific CCR2 antagonist (IC50s: 180 nM for CCR2b). It potently inhibits MCP-1-induced chemotaxis (IC50: 24 nM).		Others
T78806	PPARδ agonist 9		PPAR
	PPARδ agonist 9 (compound 21), with an EC50 of 3.6 nM, is effective in vivo, decreasing serum MCP-1 concentrations in mice and markedly reducing atherosclerotic development in the LDLr-KO model with an inhibition rate of...		PPAR
T36130	22(S)-hydroxy Cholesterol	22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol
	22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatoc...
T80059	Complement factor I		Endogenous Metabolite
	Complement factor I, a serine protease, attenuates complement activity both in the fluid phase and on cell surfaces, working alongside cofactors such as factor H (FH), complement receptor 1 (CR1/CD35), C4 binding protein...		Endogenous Metabolite
T36198	Avenanthramide-C methyl ester
	Avenanthramide-C methyl ester is an inhibitor of NF-κB activation that acts by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM). Through this mechanism, avenanthramide-C methyl ester dose dependently inhibits t...
T68721	Cantharidin imide
	Cantharidin imide is a PP1/2A inhibitor found in Canarthis vesicatoria. It inhibits proliferation of colorectal cancer cells, increases MCP-1, IL-6, and IL-β levels, and inhibits differentiation and resorptive activity o...
T37644	Bengamide B
	Potent inhibitor of NF-κB activation (IC50 = 85 nM); decreases IκBα phosphorylation. Attenuates LPS-induced nitric oxide production and expression of TNF-α, IL-6 and MCP. Suppresses proliferation of HeLa and HCT116 cell...
T82233	HCAR2 agonist 1
	HCAR2 agonist 1 (Compound 9n), a G i protein-biased allosteric modulator of HCAR2, activates the G i protein signaling pathway and exhibits anti-inflammatory properties by reducing mRNA levels of pro-inflammatory cytokin...
T71884	ß-Carboline-1-carboxylic acid
	β-Carboline-1-carboxylic acid is an alkaloid that has been found in P. quassioides and has diverse biological activities. It reduces LPS-induced increases in MCP-1, TNF-α, IL-6, and IL-1β levels in RAW 264.7 cells when u...
T11647	INCB 3284 dimesylate		Others
	INCB 3284 dimesylate is a selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2 (IC50: 3.7 nM). It can be used in the research of acute liver failure.		Others
T7499	TAK-779	Takeda 779	HIV Protease , CXCR , CCR
	TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).		HIV Protease , CXCR , CCR
T14845	BX471 hydrochloride	ZK-811752 hydrochloride	Others
	BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist (Ki: 1 nM for human CCR1). It shows 250-fold selectivity for CCR1 over CCR2, CCR5, and CXCR4.		Others
T37861	Talabostat
	Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 ...

Compounds

MCP110

T24437

Synonym: MCP-110,MCP 110

Target: Raf, Ras

1V209

T8316

Synonym: TLR7 agonist T7

Target: TLR

CCR2 antagonist 4

T13114

Synonym: Teijin compound 1

Target: CCR

MCPA

T20701

Synonym: NSC-2351,Krezone,NSC2351,NSC 2351,U 46 M-Fluid,Raphone

Target: Others

(RS)-MCPG

T3479

Synonym: alpha-MCPG,(±)-MCPG

Target: GluR

MCPA-thioethyl

T20948

Synonym: HOK 7501,HOK7501,HOK-7501

(RS)-MCPG disodium salt

Synonym: m-Chlorophenylbiguanide

Synonym: n-docosahexaenoyl dopamine,Dha-DA conjugate

Target: Dopamine Receptor

CCR2 antagonist 4 hydrochloride

T19230

Synonym: Teijin compound 1 hydrochloride

22(S)-hydroxy Cholesterol

T36130

Synonym: 22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol

Target: Endogenous Metabolite

Avenanthramide-C methyl ester

ß-Carboline-1-carboxylic acid

Target: HIV Protease, CXCR, CCR

BX471 hydrochloride

T14845

Synonym: ZK-811752 hydrochloride

Cat No.	Product Name	Synonyms	Targets
T6413	Bindarit	AF2838	CCR
	Bindarit (AF2838) displays specific inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.		CCR
TC0036	Compound Lup-20(29)-en-3-yl acetate		IL Receptor , VEGFR , Others , TNF , COX
	Lupeol acetate, a derivative of Lupeol, inhibits the progression of rheumatoid arthritis by downregulating TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B.		IL Receptor , VEGFR , Others , TNF , COX
T4S0795	Berberrubine chloride	9-Berberoline Chloride,Beroline,Beroline Chloride,Berberrubine,9-Berberoline	IL Receptor
	1. Berberrubine chloride (9-Berberoline Chloride) has antitumor activity. 2. Berberrubine has antidiabetic activity. 3. Berberrubine dose-dependently inhibits IL-8 and MCP-1 protein levels in the media and mRNA expressio...		IL Receptor
T5688	Micheliolide		NOS , NF-κB , COX
	Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.		NOS , NF-κB , COX
TN1154	Nepetin	6-Methoxyluteolin	Calcium Channel , Histamine Receptor
	Nepetin (6-Methoxyluteolin) has antioxidant activity, it is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain.		Calcium Channel , Histamine Receptor
T4S0350	Licochalcone B		Beta Amyloid , Others
	1. Licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (murine bladder cancer cell line) tumor model. 2. LCB and Licoc...		Beta Amyloid , Others
TN5593	Euphohelioscopin A
	Euphohelioscopin A, an activator of protein kinase C (PKC), it inhibits proliferation and induces differentiation of the myeloid leukemia cell lines THP-1 and HL-60. Euphohelioscopin A has anti-inflammary activity, it ex...
T38285	C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))	C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))	Others
	C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z)) is the predominant sulfate analog in the mature myelin sheath. C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z)) interacted with C-type lectin and immunoglobulin-like...		Others

Natural Products

Compound Lup-20(29)-en-3-yl acetate

TC0036

Synonym:

Target: IL Receptor, VEGFR, Others, TNF, COX

Berberrubine chloride

T4S0795

Synonym: 9-Berberoline Chloride,Beroline,Beroline Chloride,Berberrubine,9-Berberoline

Target: NOS, NF-κB, COX

Nepetin

TN1154

Synonym: 6-Methoxyluteolin

Target: Calcium Channel, Histamine Receptor

Licochalcone B

T4S0350

Synonym:

Target: Beta Amyloid, Others

C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))

T38285

Synonym: C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))

Target: Others

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02104	MCP-2 Protein, Mouse, Recombinant (His & NusA)	Mouse	E. coli
	MCP-2 Protein, Mouse, Recombinant (His & NusA) is expressed in E. coli expression system with His and NusA tag. The predicted molecular weight is 66 kDa and the accession number is Q9Z121.
TMPY-00118	MCP-1/CCL2 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	MCP-1/CCL2 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 10.1 kDa and the accession number is P13500.
TMPY-01866	MCP-3 Protein, Human, Recombinant (His)	Human	E. coli
	MCP-3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 10.5 kDa and the accession number is P80098.
TMPY-04173	MCP-3 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	MCP-3 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 10.7 kDa and the accession number is A9Z1Z1.
TMPY-04680	MCP-2 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	MCP-2 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 10.3 kDa and the accession number is P80075.
TMPY-04671	MCP-5 Protein, Mouse, Recombinant (His)	Mouse	P. pastoris (Yeast)
	Ccl12 prevented initiation of the reparative response by prolonging inflammation and inhibiting fibroblast conversion to myofibroblasts, resulting in diminished scar formation. Macrophage secretion of Ccl12 directly impa...
TMPK-00916	MCP-1/CCL2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	MCP-1/CCL2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 9.79 kDa and the accession number is P61274.
TMPY-01887	MCP-2 Protein, Human, Recombinant (SUMO)	Human	E. coli
	MCP-2 Protein, Human, Recombinant (SUMO) is expressed in E. coli expression system with SUMO tag. The predicted molecular weight is 21.7 kDa and the accession number is P80075-1.
TMPY-00606	MCP-1/CCL2 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus Insect Cells
	MCP-1/CCL2 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is P10148.
TMPY-00564	MCP-4 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Monocyte Chemoattractant Proteins 4 (MCP-4/CCL13) is a member of a distinct, structurally-related subclass of CC chemokines mainly involved in recruitment of eosinphils to inflammatory sites. CCL13/MCP-4, is a CC family ...
TMPY-05653	MCP-1/CCL2 Protein, Mouse, Recombinant (His), Biotinylated	Mouse	Baculovirus Insect Cells
	MCP-1/CCL2 Protein, Mouse, Recombinant (His), Biotinylated is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is P10148.
TMPK-00011	MCP-1/CCL2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	MCP-1/CCL2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 11.5 kDa and the accession number is P13500.
TMPK-00010	MCP-1/CCL2 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	MCP-1/CCL2 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 11.5 kDa and the accession number is P13500.
TMPY-01027	Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Mast Cell Protease 1 (MMCP-1), also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. MCPT-1 is a 26 kDa β-chymase that is a component of mast cell granules. I...
TMPK-00532	CD46 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	CD46 was discovered in 1986 during a search for novel C3b-binding proteins. CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Its vital role in prev...
TMPY-03863	CAPG Protein, Human, Recombinant	Human	E. coli
	CAPG, also known as actin Regulatory Protein CAPG, is a a member of the gelsolin/villin family. Members of this family are actin-regulatory proteins. CAPG reversibly blocks the barbed ends of F-actin filaments in a Ca2+ ...
TMPK-00570	CD46 Protein, Canine, Recombinant (His)	Canine	HEK293 Cells
	CD46 was discovered in 1986 during a search for novel C3b-binding proteins. CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Its vital role in prev...
TMPK-00879	CCR2b Protein-VLP, Human, Recombinant	Human	HEK293 Cells
	The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major chemoattractant for monocytes, involved in an array of chronic inflammator...
TMPY-02023	CD46 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CD46, also known as Membrane Cofactor Protein (MCP), is a complement regulatory protein. CD46 is a type 1 membrane protein that plays an important inhibitory role in the complement system. CD46 is expressed in white bloo...
TMPJ-00852	CCL2 Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	Monocyte chemoattractant protein 1 (MCP-1), also called CCL2, is a member of the beta (C-C) subfamily of chemokines that is a chemoattractant for monocytes and basophils but not eosinophils or neutrophils. CCL2 binds the...
TMPJ-00010	CCL8 Protein, Human, Recombinant	Human	E. coli
	CCL8 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 12 KDa and the accession number is P80075.
TMPJ-00028	CCL2 Protein, Mouse, Recombinant	Mouse	E. coli
	C-C motif chemokine 2 (CCL2) is a member of the C-C or β chemokine family. Mouse CCL2 shares 82% amino acid (aa) identity with rat CCL2 over the entire sequence, and 58%, 56%, 55%, 53% and 53% aa identity with human, equ...
TMPJ-00591	CCL8 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CCL8 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 13 KDa and the accession number is AAI26243.1.
TMPJ-00009	CCL2 Protein, Human, Recombinant	Human	E. coli
	The chemokine (C-C motif) ligand 2 (CCL2), also known as monocyte chemoattractant protein (MCP)-1 and small inducible cytokine A2 (SCYA2)), is a small cytokine that belongs to the CC chemokine family responsible for mono...
TMPH-03330	Mcpt4 Protein, Rat, Recombinant (His & Myc)	Rat	E. coli
	N/A. Mcpt4 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-6xHis and C-Myc tag. The predicted molecular weight is 30.5 kDa and the accession number is P97592.
TMPH-03329	Mcpt2 Protein, Rat, Recombinant (His & Myc)	Rat	E. coli
	This enzyme, isolated from small intestine, specifically inactivates the apo forms of a certain group of intracellular pyridoxal phosphate-requiring enzymes. It has chymotrypsin-like specificity towards small substrates....
TMPH-02779	Mcpt4 Protein, Mouse, Recombinant (His)	Mouse	P. pastoris (Yeast)
	Mcpt4 Protein, Mouse, Recombinant (His) is expressed in Yeast.
TMPH-02778	Mcpt4 Protein, Mouse, Recombinant (E. coli, His)	Mouse	E. coli
	Has chymotrypsin-like activity. Hydrolyzes the amide bonds of synthetic substrates having Tyr and Phe residues at the P1 position. Preferentially hydrolyzes the 'Tyr-4-\|-Ile-5' bond of angiotensin I and the 'Phe-20-\|-Ala...
TMPH-03328	Mcpt1 Protein, Rat, Recombinant (Myc)	Rat	E. coli
	Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. May participate in generating perivascular beta-protein wh...
TMPJ-00968	NAMPT Protein, Human, Recombinant (His)	Human	E. coli
	Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, but it is also acknowledged to be the ubiquitous intracellular e...
TMPY-04411	YES1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Proto-oncogene tyrosine-protein kinase Yes, also known as Proto-oncogene c-Yes, p61-Yes and YES1, is a cytoplasm protein that belongs to the protein kinase superfamily, Tyr protein kinase family and SRC subfamily. YES1 /...