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NMI 8739

Catalog No. T11079 CAS 129024-87-9

Synonyms: n-docosahexaenoyl dopamine, Dha-DA conjugate

NMI 8739 (n-docosahexaenoyl dopamine) is an agonist of D2 autoreceptor. NMI 8739 reduces NO production and elicits concentration-dependent suppression of CCL-20, MCP-1 and IL-6 release.

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NMI 8739, CAS 129024-87-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 50.00
5 mg	In stock	$ 95.00
10 mg	In stock	$ 133.00
25 mg	In stock	$ 217.00
50 mg	In stock	$ 318.00
100 mg	In stock	$ 472.00
500 mg	In stock	$ 1,080.00
1 mL * 10 mM (in DMSO)	In stock	$ 118.00

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Purity: 98.51%

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Description	NMI 8739 (n-docosahexaenoyl dopamine) is an agonist of D2 autoreceptor. NMI 8739 reduces NO production and elicits concentration-dependent suppression of CCL-20, MCP-1 and IL-6 release.
In vitro	NMI 8739 (2 μM) significantly inhibits IL-6 and CCL-20 release up to 49% and 37%, respectivel. NMI 8739 suppresses the production of PGE2 in a concentration-dependent manner with 25.3%, 75% reduction at doses of 100 nM and 1 μM, respectively[2].

Synonyms	n-docosahexaenoyl dopamine, Dha-DA conjugate
Molecular Weight	463.65
Formula	C30H41NO3
CAS No.	129024-87-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 90 mg/mL (194.1 mM), Sonification is recommended.

DMSO: 90 mg/mL (194.1 mM)

References and Literature

1. Shashoua VE, et al. N-docosahexaenoyl, 3 hydroxytyramine: a dopaminergic compound that penetrates the blood-brain barrier and suppresses appetite. Life Sci. 1996;58(16):1347-57. 2. Wang Y, et al. N-Docosahexaenoyl Dopamine, an Endocannabinoid-like Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, Attenuates Lipopolysaccharide-Induced Activation of Microglia and Macrophages via COX-2. ACS Chem Neurosci. 2017 Mar 15;8(3):548-557. 3. Gill Higgins. New drugs signal rapid growth of anti-obesity drug market. RESEARCH & DEVELOPMENT. 2 Nov 11K16 No. 1061

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library GPCR Compound Library Bioactive Compound Library Neuronal Signaling Compound Library Bioactive Compounds Library Max Antidepressant Compound Library Neurotransmitter Receptor Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NMI 8739 129024-87-9 GPCR/G Protein Neuroscience Dopamine Receptor n-docosahexaenoyl dopamine NMI8739 NMI-8739 Dha-DA conjugate inhibitor inhibit

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