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TAK-779

TAK-779
TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
Catalog No. T7499Cas No. 229005-80-5
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Purity:99.21%
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TAK-779

Catalog No. T7499Cas No. 229005-80-5
TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$38In Stock
5 mg$89In Stock
10 mg$139In Stock
25 mg$253In Stock
50 mg$428In Stock
100 mg$639In Stock
1 mL x 10 mM (in DMSO)$97In Stock
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Product Introduction

Bioactivity
Description
TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
Targets&IC50
RANTES-CCR5:1.4 nM (in CHO/CCR5 cells), MIP-1α-CCR5:1 nM (in CHO/CCR5 cells), R5 HIV-1 (Ba-L):1.2 nM (EC50, in MAGI-CCR5 cells), R5 HIV-1 (Ba-L):3.7 nM (EC50, in PBMCs), MCP-1-CCR2b:27 nM (in CHO/CCR5 cells), MIP-1β-CCR5:1 nM (in CHO/CCR5 cells), R5 HIV-1 (KK):1.6 nM (EC50, in PBMCs)
In vitro
TAK-779 (250 mg/animal per day) inhibits ovalbumin-induced increases in CCR5, CXCR3, IFN-γ, and TNF-α expression in mouse lung, as well as the number of total cells, lymphocytes, and eosinophils in bronchoalveolar lavage fluid (BALF), in a mouse model of asthma[1].
In vivo
TAK-779 increases intestinal allograft survival in a rat model of small intestine transplantation when administered at a dose of 10 mg/kg per day[2].
AliasTakeda 779
Chemical Properties
Molecular Weight531.13
FormulaC33H39ClN2O2
Cas No.229005-80-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 16.66 mg/mL (31.37 mM)
DMSO: 25 mg/mL (47.07 mM)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.8828 mL9.4139 mL18.8278 mL94.1389 mL
5 mM0.3766 mL1.8828 mL3.7656 mL18.8278 mL
10 mM0.1883 mL0.9414 mL1.8828 mL9.4139 mL
20 mM0.0941 mL0.4707 mL0.9414 mL4.7069 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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