Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CCR2 antagonist 4 hydrochloride is a specific CCR2 antagonist (IC50s: 180 nM for CCR2b). It potently inhibits MCP-1-induced chemotaxis (IC50: 24 nM).
Pack Size | Availability | Price/USD | Quantity |
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2 mg | 5 days | $ 52.00 |
Description | CCR2 antagonist 4 hydrochloride is a specific CCR2 antagonist (IC50s: 180 nM for CCR2b). It potently inhibits MCP-1-induced chemotaxis (IC50: 24 nM). |
Targets&IC50 | CCR2b:180 nM |
In vitro | Ile263 and Thr292 in CCR2 contribute significantly to the binding of CCR2 antagonist 4 in CCR2. His121 on TM3 and Ile263 on TM6 also strongly interact with CCR2 antagonist 4 hydrochloride. Residue Glu291 in TM7 contributes substantially to the binding of the protonated CCR2 antagonist 4 hydrochloride, and CCL2 [2]. |
In vivo | In ApoE-deficient mice, CCR2 antagonist 4 hydrochloride reduces the mouse monocyte/macrophage cell line (RAW 264.7) adhesion/ infiltration into the aorta [3]. |
Synonyms | Teijin compound 1 hydrochloride |
Molecular Weight | 476.32 |
Formula | C21H22Cl2F3N3O2 |
CAS No. | 1313730-14-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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CCR2 antagonist 4 hydrochloride 1313730-14-1 Others Teijin compound 1 Hydrochloride CCR2 antagonist 4 Hydrochloride CCR-2 antagonist 4 hydrochloride Teijin compound 1 hydrochloride inhibitor inhibit