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1V209

Catalog No. T8316 CAS 1062444-54-5

Synonyms: TLR7 agonist T7

1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

1V209, CAS 1062444-54-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 32.00
2 mg	In stock	$ 45.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 128.00
25 mg	In stock	$ 287.00
50 mg	In stock	$ 455.00
100 mg	In stock	$ 672.00
1 mL * 10 mM (in DMSO)	In stock	$ 79.00

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Purity: 98.53%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.
In vitro	The small molecule synthetic TLR7 ligand, 2-methoxyethoxy-8-oxo-9-(4-carboxy benzyl)adenine (1V209), and α-mannose were coimmobilized via linker molecules consisting of thioctic acid on the GNP surface (1V209-αMan-GNPs).?The in vitro cytokine production activity of 1V209-αMan-GNPs was higher than that of the unconjugated 1V209 derivative in mouse bone marrow-derived dendritic cells and in human peripheral blood mononuclear cells[1].
In vivo	In the in vivo immunization study, 1V209-αMan-GNPs induced significantly higher titers of IgG2c antibody specific to ovalbumin as an antigen than did unconjugated 1V209, and splenomegaly and weight loss were not observed[1].

Synonyms	TLR7 agonist T7
Molecular Weight	359.34
Formula	C16H17N5O5
CAS No.	1062444-54-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 83.33 mg/mL (231.90 mM), Sonification is recommended.

References and Literature

1. Gold Nanoparticles Coimmobilized with Small Molecule Toll-Like Receptor 7 Ligand and α‑Mannose as Adjuvants[J]. Bioconjugate Chemistry, 2019, 30(11):2811-2821. 2. Shinchi H, et al. Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides. Bioconjug Chem. 2015 Aug 19;26(8):1713-23. 3. Battistella C, et al. Delivery of Immunotherapeutic Nanoparticles to Tumors via Enzyme-Directed Assembly. Adv Healthc Mater. 2019 Dec;8(23):e1901105.

Citations

1. Liang C, Xiong N, Liu M, et al.Manganese immunotherapy for treating osteosarcoma: Glycosylating 1V209 anchored MnO2 nanosheets prompt pro-inflammatory macrophage polarization.Nano Today.2023, 48: 101670.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Cancer Compound Library Reprogramming Compound Library Immuno-Oncology Compound Library Bioactive Compound Library Immunology/Inflammation Compound Library Pyroptosis Compound Library Bioactive Compounds Library Max NO PAINS Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

1V209 1062444-54-5 Immunology/Inflammation TLR cell polysaccharides 1V-209 1V 209 IP-10 intravenous TLR7 agonist T7 MCP-1 Tumor IL-6 Toll-like Receptor (TLR) conjugate Inhibitor cancer TNFα inhibit inhibitor

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