Search Result

Search Results for " ifn α 1 "

Targets

Compounds

Natural Products

1741

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T11630	IFN alpha-IFNAR-IN-1 hydrochloride		Others , IFNAR
	IFN alpha-IFNAR-IN-1 hydrochloride is an inhibitor of the interaction between IFN-α and IFNAR. IFN alpha-IFNAR-IN-1 hydrochloride inhibits MVA-induced IFN-α responses by BM-pDCs with IC50 of 2-8 μM.		Others , IFNAR
TP1117	IFN-α Receptor Recognition Peptide 1	IRRP1
	IFN-α Receptor Recognition Peptide 1, associated with receptor interactions, is a peptide of IFN-α.
T11630L	IFN alpha-IFNAR-IN-1		Others
	IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR. It inhibits MVA-induced IFN-α responses by BM-pDCs (IC50: 2-8 μM).		Others
T13063	T6167923		MyD88
	T6167923 is a potent, selective inhibitor of MyD88-dependent signaling pathways. It achieves this by directly binding to the Toll/IL1 receptor (TIR) domain of MyD88, preventing MyD88 homodimer formation. Subsequently, T6...		MyD88
T81259	Rontalizumab	RhuMab IFNalpha,Anti-Human IFN alpha Recombinant Antibody
	Rontalizumab, a humanized IgG1 monoclonal antibody, targets IFN-α and is utilized in research on systemic lupus erythematosus[1].
T76853	Ropeginterferon alfa-2b
	Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft), a monopegylated interferon-alpha (IFN-α), is utilized in the study of myeloproliferative neoplasms [1].
T83152	AJ2-71
	AJ2-71 is a SLC15A4 inhibitor that suppresses IFN-α production and obstructs SLC15A4-mediated MDP transport, making it suitable for research of inflammation [1].
T60266	(Rac)-Indoximod
	(Rac)-Indoximod (1-Methyl-DL-tryptophan) is a potent inhibitor of indoleamine 2,3-dioxygenase (IDO). Combined treatment with IFN-γ and (Rac)-Indoximod significantly suppresses the activity of α-SMA-expressing human cardi...
T74908	ODN 2336
	ODN 2336, an A-Class CpG oligodeoxynucleotide (ODN), serves as a potent TLR9 agonist. It effectively induces IFN-α production and up-regulates IP-10 and IL-18 mRNA expression, leveraging its role as a vaccine adjuvant [1...
T38008	KBC-007
	KBC-007 is a synthetic branched chain-containing analog of α-galactosylceramide (α-GalCer). It induces IL-4 and IFN-γ secretion by mouse splenocytes when used at a concentration of 0.5 ng/ml and IL-2 secretion by DN32.D3...
T74913	ODN 6016
	ODN 6016, a CpG-A oligonucleotide, shows potential in inducing IFN-α production, primarily for studying immune disorders such as immunodeficiency due to HIV-1. Its sequence is T-sp-C-G-A-C-G-T-C-G-T-G-G-sp-G-sp-G-sp-G [1...
T72017	6(5H)-Phenanthridinone
	6(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2. It decreases radiation-induced PARP activity and proliferation of RDM4 murine lymphoma cells. 6(5H)-Phenanthridinone reduces NF-κ...
T74911	ODN 24987
	ODN 24987, a Guanine-modified inhibitory oligonucleotides (ODN) designed to target TLR9, efficiently suppresses the release of IL-6 and IFN-α, showcasing its potential utility in research on immune disorders. The sequenc...
T78953	SIMR3030		SARS-CoV
	SIMR3030, a potent inhibitor of SARS-CoV-2 PLpro, possesses an IC50 of 0.0399 µg/mL and demonstrates antiviral activity by diminishing the expression of SARS-CoV spike, ORF1b, IFN-α, and IL-6 mRNA. Additionally, SIMR3030...		SARS-CoV
T74907	ODN 21595
	ODN 21595, a guanine-modified inhibitor targeting TLR7 and TLR9, effectively inhibits the release of IFN-α and IL-6 without exhibiting cytotoxicity. It also reduces the expression of CD86 and HLA-DR, showcasing potential...
T75092	STING agonist-24
	STING agonist-24 (CF504), a non-nucleotide small-molecule STING agonist, activates STING, leading to increased phosphorylation of STING, TBK1, and IRF3. It elevates levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-...
T78508	Delmitide acetate	RDP-58 acetate	IFNAR
	Delmitide acetate (RDP58) is an orally active d-isomer decapeptide that exhibits potent anti-inflammatory properties. This compound suppresses the production of TNF-α, IFN-γ, and interleukin (IL)-12, while enhancing the ...		IFNAR
T75094	STING agonist-26
	STING agonist-23 (CF508), a non-nucleotide small-molecule STING agonist, activates STING, thereby enhancing the phosphorylation of STING, TBK1, and IRF3. This activation elevates the production of IFN-β, IL-6, CXCL-10, T...
T75093	STING agonist-25
	STING agonist-23 (CF505) is a non-nucleotide, small-molecule compound that stimulates STING, enhancing the phosphorylation of STING, TBK1, and IRF3. It elevates the production of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and ...
T75096	STING agonist-28
	STING agonist-23 (CF510) is a non-nucleotide, small-molecule activator of the STING pathway. It initiates the phosphorylation of STING, TBK1, and IRF3, enhancing the production of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and...
T74910	ODN 24888
	ODN 24888, a guanine-modified inhibitory oligonucleotide (INH-ODN), effectively inhibits TLR7/TLR9-mediated signaling, reducing IFN-α levels and NF-κB activation, and suppressing IL-6 release. This compound plays a role ...
T74915	ODN D-SL03
	ODN D-SL03, a class C CpG oligonucleotide, effectively stimulates peripheral blood mononuclear cells (PBMCs) to produce high levels of IFN-α. It activates human B cells, NK cells, and mononuclear cells, elevating the exp...
T75091	STING agonist-23
	STING agonist-23 (CF502) is a non-nucleotide, small-molecule stimulator of the STING pathway. Upon activation, it enhances the phosphorylation of STING, TBK1, and IRF3, leading to elevated levels of IFN-β, IL-6, CXCL-10,...
T38161	STING Agonist C11	STING Agonist C11
	STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphory...
T36779	NG 25 (hydrochloride hydrate)
	NG 25 is a type II kinase inhibitor that inhibits MAP4K2 and TAK1 (IC50s = 21.7 and 149 nM, respectively).1It also inhibits the Src family kinases Src and LYN (IC50s = 113 and 12.9 nM, respectively) and Abl family kinase...
T76945	Cetrelimab
	Cetrelimab (JNJ 63723283; JNJ 3283), a humanized IgG4κ monoclonal antibody (mAb) targeting PD-1, binds to PD-1 (Kd=1.72 nM, HEK293) to prevent its interaction with PD-L1 and PD-L2 (IC50s=111.7 ng/mL and 138.6 ng/mL, resp...
T61071	AX-024
	AX-024 is a novel chemical compound that acts as an orally available inhibitor of the TCR-Nck interaction. Its primary mechanism of action is the selective inhibition of T cell activation triggered by TCR stimulation. Wi...
T36486	Benpyrine
	Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the poten...

Compounds

IFN alpha-IFNAR-IN-1 hydrochloride

T11630

Synonym:

Target: Others, IFNAR

IFN-α Receptor Recognition Peptide 1

TP1117

Synonym: IRRP1

Target:

IFN alpha-IFNAR-IN-1

Synonym: RhuMab IFNalpha,Anti-Human IFN alpha Recombinant Antibody

Target:

Ropeginterferon alfa-2b

6(5H)-Phenanthridinone

Synonym: RDP-58 acetate

Synonym: STING Agonist C11

Target:

NG 25 (hydrochloride hydrate)

Cat No.	Product Name	Synonyms	Targets
T6S0139	Neobavaisoflavone		Apoptosis , DNA/RNA Synthesis
	1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity, can si...		Apoptosis , DNA/RNA Synthesis

Natural Products

Neobavaisoflavone

T6S0139

Synonym:

Target: Apoptosis, DNA/RNA Synthesis

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-04578	Interferon alpha 1/IFNA1 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Interferon alpha 1/IFNA1 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 20.8 kDa and the accession number is L0N195.
TMPY-02647	IFNAR1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	IFNAR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48.6 kDa and the accession number is P17181-1.
TMPK-00074	IFN-alpha 1/IFNA1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I o...
TMPK-00325	IFNAR1 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	IFNAR1 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 50.2 kDa and the accession number is P17181-1.
TMPK-00342	IFNAR1 Protein, Mouse, Recombinant (His & Avi)	Mouse	HEK293 Cells
	IFNAR1 Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 46.9 kDa and the accession number is P33896.
TMPK-00075	IFN-alpha 1/IFNA1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I o...
TMPK-00326	IFNAR1, Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	IFNAR1, Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 50.2 kDa and the accession number is P17181-1.
TMPK-00343	IFNAR1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	IFNAR1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 72.5 kDa and the accession number is P33896.
TMPY-02634	IFNAR1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	IFNAR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 74 kDa and the accession number is P17181-1.
TMPJ-00331	IFNAR1 Protein, Rhesus macaque, Recombinant (His)	Rhesus	HEK293 Cells
	Interferon‑alpha/beta receptor 1 (IFN‑ alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-...
TMPY-02549	GBP1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Guanylate-binding protein 1 (GBP-1) is a member of the GBP family whose members are GTPases induced in response to interferon-λ (IFN-λ), with seven highly homologous members in humans, termed HuGBP-1 to HuGBP-7. GBP-1 ex...
TMPJ-00177	BAFF/TNFSF13B Protein, Human, Recombinant (Avi & hFc), Biotinylated	Human	HEK293 Cells
	B-cell activating factor (BAFF), also known as BLyS, TALL-1, THANK, and TNFSF13B, is a transmembrane glycoprotein in the TNF ligand superfamily. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), T...
TMPY-04451	AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 160 kDa and the accession number is P54619-1&Q9Y478-1&...
TMPY-03745	CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His)	Human	HEK293 Cells
	CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 31.05 kDa and the accession number is P04234-1&P07766-1.
TMPY-03878	Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)	Human	HEK293 Cells
	Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 190.4 kDa and the accession number is P06756-1&P18564-1.
TMPY-02501	CD3D & CD3E Heterodimer Protein, Human, Recombinant	Human	HEK293 Cells
	CD3D & CD3E Heterodimer Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 77.5 kDa and the accession number is P04234-1&P07766-1.
TMPY-02335	OSMR Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	OSMR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 83.7 kDa and the accession number is O70458-1.
TMPY-02112	FGFR4 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	FGFR4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22455-1.
TMPY-01920	BAFF/TNFSF13B Protein, Human, Recombinant (HEK293)	Human	HEK293 Cells
	BAFF/TNFSF13B Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 17 kDa and the accession number is Q9Y275-1.
TMPY-02591	SDF-1 Protein, Human, Recombinant	Human	E. coli
	SDF-1 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 8.6 kDa and the accession number is P48061-1.
TMPY-01053	Prolactin Receptor Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Prolactin Receptor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P16471-1.
TMPY-01349	ICAM-1/CD54 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	ICAM-1/CD54 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.7 kDa and the accession number is P13597-1.
TMPY-00820	IgG1 Fc Protein, Human, Recombinant (C103S)	Human	HEK293 Cells
	IgG1 Fc Protein, Human, Recombinant (C103S) is expressed in HEK293 mammalian cells. The predicted molecular weight is 26 kDa and the accession number is P01857-1.
TMPY-00742	EGFR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	EGFR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69.8 kDa and the accession number is P00533-1.
TMPY-02603	STAT6 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6...
TMPY-01003	TCN2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	TCN2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.7 kDa and the accession number is P20062-1.
TMPY-06873	FLT3 Ligand Protein, Human, Recombinant	Human	E. coli
	FLT3 Ligand Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.75 kDa and the accession number is P49771-1.
TMPY-01968	CD32A Protein, Human, Recombinant (167 His, His)	Human	HEK293 Cells
	CD32A Protein, Human, Recombinant (167 His, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22 kDa and the accession number is P12318-1.
TMPY-01395	CTHRC1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CTHRC1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.5 kDa and the accession number is Q96CG8-1.
TMPY-01389	HER3/ERBB3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	HER3/ERBB3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.2 kDa and the accession number is P21860-1.
TMPY-01813	ACRV1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Acrosomal protein SP-1, also known as Acrosomal vesicle protein 1 and ACRV1, is a testis-specific, differentiation antigen, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the a...
TMPY-02700	BCL2 Protein, Human, Recombinant (His)	Human	E. coli
	BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family a...
TMPY-05840	IL-1RAP/IL-1RAcP Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	IL-1RAP/IL-1RAcP Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.56 kDa and the accession number is P59822-1.
TMPY-04104	LIF Protein, Human, Recombinant	Human	HEK293 Cells
	LIF Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 19.7 kDa and the accession number is P15018-1.
TMPY-04939	LAG-3 Protein, Human, Recombinant	Human	HEK293 Cells
	LAG-3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 45.3 kDa and the accession number is P18627-1.
TMPY-00925	SOST Protein, Human, Recombinant (His)	Human	HEK293 Cells
	SOST Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.5 kDa and the accession number is Q9BQB4-1.
TMPY-02062	SULT1A1 Protein, Human, Recombinant (His)	Human	E. coli
	Sulfate conjugation catalyzed by cytosolic sulfotransferase (SULT) enzymes. The SULTs are Phase II drug-metabolizing enzymes that catalyze the addition of a sulfuryl moiety to both endogenous compounds, including steroid...
TMPY-03782	Albumin Protein, Human, Recombinant	Human	P. pastoris (Yeast)
	Albumin Protein, Human, Recombinant is expressed in yeast. The predicted molecular weight is 66.4 kDa and the accession number is P02768-1.
TMPY-00843	IL-25/IL17E Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	IL-25/IL17E Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45 kDa and the accession number is Q9H293-1.
TMPY-04153	RNF43 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expr...
TMPY-01209	IL-7R alpha/CD127 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	IL-7R alpha/CD127 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is P16871-1.
TMPY-05566	Siglec-2/CD22 Protein, Human, Recombinant (His, Solution)	Human	HEK293 Cells
	Siglec-2/CD22 Protein, Human, Recombinant (His, Solution) is expressed in HEK293 mammalian cells with His tag. The accession number is P20273-1.
TMPY-01137	HER2/ERBB2 Protein, Human, Recombinant (aa 1-652, His)	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (aa 1-652, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71 kDa and the accession number is P04626-1.
TMPY-05593	IL-1RAP/IL-1RAcP Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	IL-1RAP/IL-1RAcP Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 42.4 kDa and the accession number is Q9NPH3-1.
TMPY-00835	IGFBP-3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	IGFBP-3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31 kDa and the accession number is P17936-1.
TMPY-04824	CTLA-4 Protein, Human, Recombinant	Human	HEK293 Cells
	CTLA-4 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 13.5 kDa and the accession number is P16410-1.
TMPY-01062	EGF Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	EGF Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 33 kDa and the accession number is P01133-1.
TMPY-00686	Complement C2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Complement C2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82.5 kDa and the accession number is P06681-1.
TMPY-01934	IL-21R Protein, Human, Recombinant (His)	Human	HEK293 Cells
	IL-21R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is Q9HBE5-1.
TMPY-01145	NKp30/NCR3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	NKp30/NCR3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.4 kDa and the accession number is O14931-1.
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