Powder: -20°C for 3 years | In solvent: -80°C for 2 years
T6167923 is a potent and selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity. T6167923 improves anti-inflammatory activity with IC50s of 2.7 μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 225.00 | |
5 mg | In stock | $ 562.00 | |
10 mg | In stock | $ 791.00 | |
25 mg | In stock | $ 1,230.00 | |
50 mg | In stock | $ 1,670.00 | |
100 mg | In stock | $ 2,250.00 |
Description | T6167923 is a potent and selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity. T6167923 improves anti-inflammatory activity with IC50s of 2.7 μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively [1]. |
Molecular Weight | 458.39 |
Formula | C17H20BrN3O3S2 |
CAS No. | 2437475-16-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
DMSO: 250 mg/mL (545.39 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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T6167923 2437475-16-4 Immunology/Inflammation MyD88 T-6167923 inhibitor inhibit