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T6167923

Catalog No. T13063 CAS 2437475-16-4

T6167923 is a potent and selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity. T6167923 improves anti-inflammatory activity with IC50s of 2.7 μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively [1].

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T6167923, CAS 2437475-16-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 225.00
5 mg	In stock	$ 562.00
10 mg	In stock	$ 791.00
25 mg	In stock	$ 1,230.00
50 mg	In stock	$ 1,670.00
100 mg	In stock	$ 2,250.00

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Purity: 99.23%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	458.39
Formula	C17H20BrN3O3S2
CAS No.	2437475-16-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 250 mg/mL (545.39 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Saqib U, et al. Identifying the inhibition of TIR proteins involved in TLR signalling as an anti-inflammatory strategy. SAR QSAR Environ Res. 2018 Apr;29(4):295-318. 2. Olson MA, et al. Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen. Sci Rep. 2015 Sep 18;5:14246.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library NO PAINS Compound Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library

Related Products

Related compounds with same targets

EM 163 CL075 TLR1 TJ-M2010-5 Schaftoside MyD88-IN-1

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

T6167923 2437475-16-4 Immunology/Inflammation MyD88 T-6167923 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.