cyp2d6 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10835	Cletoquine	Desethylhydroxychloroquine	Parasite , Antifection
	Cletoquine is a major active metabolite of Hydroxychloroquine. Cletoquine has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune disease treatme...		Parasite , Antifection
T16369	O-Desmethyl gefitinib		EGFR
	O-Desmethyl gefitinib inhibits EGFR (IC50: 36 nM in subcellular assays). In human plasma, O-Desmethyl gefitinib is an active metabolite of Gefitinib. The formation of O-desmethyl gefitinib is dependent on the CYP2D6 acti...		EGFR
T28827	Sofpironium bromide	BBI4000,BBI 4000,BBI-4000	Others , AChR
	Sofpironium bromide (BBI4000) belongs to a class of drugs called anticholinergics, which exert their effect by blocking the action of acetylcholine.		Others , AChR
T10989	Dehydroaripiprazole	OPC-14857,DM-14857	5-HT Receptor
	Dehydroaripiprazole (DM-14857) is the active metabolite of aripiprazole. Aripiprazole is an antipsychotic drug, which is metabolized by CYP3A4 and CYP2D6 and mainly forms dehydroaripiprazole. Dehydroaripiprazole has anti...		5-HT Receptor
T10335	Antihistamine-1		P450
	Antihistamine-1 is an H1-antihistamine (Ki: 6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel (IC50s: 5.4 and 0.8 μM).		P450
T8182	Guanfu base A	Guan-fu base A	P450 , Potassium Channel , HER
	Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.		P450 , Potassium Channel , HER
T34795	Tedatioxetine	Lu AA 24530,Lu AA-24530,Lu AA24530	Dopamine Receptor , Serotonin Transporter
	Tedatioxetine (Lu AA24530) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) with antidepressant properties.Tedatioxetine acts as a CYP2D6 substrate.		Dopamine Receptor , Serotonin Transporter
TQ0296L	N-Nornuciferine hydrochloride(4846-19-9 free base)	N-Nornuciferine hydrochloride	P450
	N-Nornuciferine hydrochloride(4846-19-9 free base) (N-Nornuciferine hydrochloride) is an aporphine alkaloid in lotus leaf, significantly inhibits CYP2D6 (IC50: 3.76 μM, Ki: 2.34 μM).		P450
T3401	Ginsenoside F1	20(S)-Ginsenoside F1	P450 , Endogenous Metabolite
	Ginsenoside F1 (20(S)-Ginsenoside F1) is an enzymatically modified derivative of ginsenoside Rg1, showing competitive inhibition of the activity of CYP3A4 and a weaker inhibition of the activity of CYP2D6.		P450 , Endogenous Metabolite
T4281	Endoxifen	(E/Z)-N-desmethyl-4-hydroxy Tamoxifen,(E/Z)-Endoxifen	Estrogen Receptor/ERR , Aromatase , Estrogen/progestogen Receptor , Parasite , Drug Metabolite
	(E/Z)-Endoxifen ((E/Z)-Endoxifen) is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-estrogen, as it has an approximately 100-f...
T8182L	Guan-fu base A hydrochloride(1394-48-5 free base)		P450
	Guan-fu base A hydrochloride is an antiarrhythmic alkaloid was isolated from Aconitum coreanum. Guanfu base A is hydrochloride a CYP2D6 inhibitor of human, monkey, and dog isoforms.		P450
T2878	Ginsenoside Rd	Panaxoside Rd,Sanchinoside Rd,Gypenoside VIII	P450 , Calcium Channel , NF-κB , COX , Endogenous Metabolite
	Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.
T1443	Memantine hydrochloride	Namenda,Memantine HCl,D-145 (hydrochloride)	P450 , GluR , NMDAR , Autophagy , iGluR
	Memantine hydrochloride (Memantine HCl) is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.		P450 , GluR , NMDAR , Autophagy , iGluR
T7788	2-Phenyl-2-(1-piperidinyl)propane		Others
	2-Phenyl-2-(1-piperidinyl)propane (PPP), an analog of phencyclidine		Others
T5S2361	Epiberberine		ERK , Beta-Secretase , MEK , BACE , AMPK , AChR , AChE
	1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways during 3T3-L1 adipocyte diffe...		ERK , Beta-Secretase , MEK , BACE , AMPK , AChR , AChE
T3736	Olivetol	5-Pentylresorcinol,5-n-Amylresorcinol	Cannabinoid Receptor , P450 , IκB/IKK
	Olivetol (5-n-Amylresorcinol) (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in various syntheses of tetrahydrocannabinol. Olivetol has an...		Cannabinoid Receptor , P450 , IκB/IKK
T4488	GSK-25	GSK25	ROCK , S6 Kinase , mTOR
	GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).		ROCK , S6 Kinase , mTOR
T50001	Tinoridine	ethyl 2-amino-6-benzyl-4H,5H,6H,7H-thieno[2,3-c]pyridine-3-carboxylate	P450
	Tinoridine is a quinoline derivative analog that acts by inhibiting the production of cyclooxygenase-2 (COX-2). It has anti-inflammatory, anti-allergic and anticoagulant activities.		P450
TQ0109	Cephaeline dihydrochloride	(-)-Cephaeline dihydrochloride,NSC 32944	P450
	(-)-Cephaeline (dihydrochloride) is an enantiomer of Cephaeline. Cephaeline is a selective CYP2D6 inhibitor (IC50: 121 μM).		P450
TQ0296	N-Nornuciferine		P450
	N-Nornuciferine, an aporphine alkaloid in lotus leaf, significantly inhibits CYP2D6 (IC50: 3.76 μM, Ki: 2.34 μM).		P450