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N-Nornuciferine

Catalog No. TQ0296 CAS 4846-19-9

N-Nornuciferine, an aporphine alkaloid in lotus leaf, significantly inhibits CYP2D6 (IC50: 3.76 μM, Ki: 2.34 μM).

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N-Nornuciferine, CAS 4846-19-9

Pack Size	Availability	Price/USD	Quantity
20 mg	In Stock (ship within 1 week)	$ 200.00
1 mL * 10 mM (in DMSO)	In Stock (ship within 1 week)	$ 110.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	N-Nornuciferine, an aporphine alkaloid in lotus leaf, significantly inhibits CYP2D6 (IC50: 3.76 μM, Ki: 2.34 μM).
Targets&IC50	CYP2D6:3.76 μM, CYP2D6:2.34 μM (Ki)
In vitro	N-Nornuciferine strongly inhibits CYP2D6 activity but shows weak or no inhibition of the other four P450 isoenzymes (CYP2C19, CYP3A4, CYP2E1, CYP2C9). N-Nornuciferine competitively inhibits the CYP2D6-catalyzed dextromethorphan O-demethylation (Ki: 2.34 μM).

Molecular Weight	281.35
Formula	C18H19NO2
CAS No.	4846-19-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: Soluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ye LH, et al. Identification and characterization of potent CYP2D6 inhibitors in lotus leaves. J Ethnopharmacol. 2014 Apr 11;153(1):190-6.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

N-Nornuciferine 4846-19-9 Metabolism P450 N Nornuciferine NNornuciferine Inhibitor inhibitor inhibit

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