Powder: -20°C for 3 years
In solvent: -80°C for 2 years
N-Nornuciferine, an aporphine alkaloid in lotus leaf, significantly inhibits CYP2D6 (IC50: 3.76 μM, Ki: 2.34 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
20 mg | In Stock (ship within 1 week) | $ 200.00 | |
1 mL * 10 mM (in DMSO) | In Stock (ship within 1 week) | $ 110.00 |
Description | N-Nornuciferine, an aporphine alkaloid in lotus leaf, significantly inhibits CYP2D6 (IC50: 3.76 μM, Ki: 2.34 μM). |
Targets&IC50 | CYP2D6:3.76 μM, CYP2D6:2.34 μM (Ki) |
In vitro | N-Nornuciferine strongly inhibits CYP2D6 activity but shows weak or no inhibition of the other four P450 isoenzymes (CYP2C19, CYP3A4, CYP2E1, CYP2C9). N-Nornuciferine competitively inhibits the CYP2D6-catalyzed dextromethorphan O-demethylation (Ki: 2.34 μM). |
Molecular Weight | 281.35 |
Formula | C18H19NO2 |
CAS No. | 4846-19-9 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: Soluble
( < 1 mg/ml refers to the product slightly soluble or insoluble )
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N-Nornuciferine 4846-19-9 Metabolism P450 N Nornuciferine NNornuciferine Inhibitor inhibitor inhibit