Powder: -20°C for 3 years | In solvent: -80°C for 1 year
O-Desmethyl gefitinib inhibits EGFR (IC50: 36 nM in subcellular assays). In human plasma, O-Desmethyl gefitinib is an active metabolite of Gefitinib. The formation of O-desmethyl gefitinib is dependent on the CYP2D6 activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 51.00 | |
5 mg | In stock | $ 113.00 | |
10 mg | In stock | $ 179.00 | |
25 mg | In stock | $ 360.00 | |
50 mg | In stock | $ 576.00 | |
100 mg | In stock | $ 825.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 123.00 |
Description | O-Desmethyl gefitinib inhibits EGFR (IC50: 36 nM in subcellular assays). In human plasma, O-Desmethyl gefitinib is an active metabolite of Gefitinib. The formation of O-desmethyl gefitinib is dependent on the CYP2D6 activity. |
Targets&IC50 | EGFR:36 nM (IC50) |
Molecular Weight | 432.88 |
Formula | C21H22ClFN4O3 |
CAS No. | 847949-49-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (63.53 mM)
You can also refer to dose conversion for different animals. More
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O-Desmethyl gefitinib 847949-49-9 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR human Gefitinib ODesmethyl gefitinib plasma inhibit HER1 CYP2D6 Epidermal growth factor receptor O Desmethyl gefitinib ErbB-1 Inhibitor inhibitor