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Memantine hydrochloride

Catalog No. T1443   CAS 41100-52-1
Synonyms: Namenda, Memantine HCl, D-145 (hydrochloride)

Memantine hydrochloride (Memantine HCl) is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.

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Memantine hydrochloride Chemical Structure
Memantine hydrochloride, CAS 41100-52-1
Pack Size Availability Price/USD Quantity
200 mg In stock $ 42.00
500 mg In stock $ 50.00
1 g In stock $ 63.00
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Purity: 99.56%
Purity: 98.05%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Memantine hydrochloride (Memantine HCl) is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.
Targets&IC50 CYP2B6:0.51 nM(Ki), CYP2D6:94.9 μM(Ki)
Synonyms Namenda, Memantine HCl, D-145 (hydrochloride)
Molecular Weight 215.763
Formula C12H22ClN
CAS No. 41100-52-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (185.4 mM)

H2O: 28 mg/mL (129.8 mM)

Ethanol: 40 mg/mL (185.4 mM)

TargetMolReferences and Literature

1. Bresink I, et al. British journal of pharmacology, 1996, 119(2): 195-204. 2. Dong L, Shen S, Chen W, et al. Discovery of Novel Inhibitors Targeting Human O-GlcNAcase: Docking-Based Virtual Screening, Biological Evaluation, Structural Modification, and Molecular Dynamics Simulation[J]. Journal of chemical information and modeling. 2019, 59(10): 4374-4382.

TargetMolCitations

1. Dong L, Shen S, Chen W, et al. Discovery of Novel Inhibitors Targeting Human O-GlcNAcase: Docking-Based Virtual Screening, Biological Evaluation, Structural Modification, and Molecular Dynamics Simulation. Journal of chemical information and modeling. 2019, 59(10): 4374-4382.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Glutamine Metabolism Compound Library Anti-Parkinson's Disease Compound Library Pediatric Drug Library Drug-Fragment Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compound Library

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Keywords

Memantine hydrochloride 41100-52-1 Autophagy Membrane transporter/Ion channel Metabolism Neuroscience P450 NMDAR GluR iGluR D145 CYPs Memantine Hydrochloride Inhibitor D 145 Namenda Ionotropic glutamate receptors D-145 Cytochrome P450 Memantine HCl D-145 (hydrochloride) inhibit Memantine inhibitor

 

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